二甲双胍（CAS 657-24-9）：分子式 C4H11N5、分子量 129.16。
| CAS号 | 657-24-9 |
|---|---|
| 分子式 | C4H11N5 |
| 分子量 | 129.16 |
| 熔点 | 223-226 °C |
| 沸点 | 224.1ºC at 760 mmHg |
| LogP | -2.6 |
| 应用领域 | Uses: MEDICATION (VET)、MEDICATION、Hypoglycemic Agents、Use (kg) in Switzerland (2009): >75000、Use (kg、approx.) in Germany (2009): >1000000、Use (kg) in USA (2002): 1450000、Use (kg) in France (2004): 716858、Consumption (g per capita) in Switzerland (2009): 9.6、Consumption (g per capita、approx.) in Germany (2009): 12、Consumption (g per capita) in the USA (2002): 5.1、Consumption (g per capita) in France (2004): 12、Excretion rate: 1、Calculated removal (%): 75.1、For use as an adjunct to diet and exercise in adult patients (18 years and older) with NIDDM. May also be used for the management of metabolic and reproductive abnormalities associated with polycystic ovary syndrome (PCOS). Jentadueto is for the treatment of patients when both linagliptin and metformin is appropriate.、Use Classification: Pharmaceuticals -> Alimentary tract and metabolism -> Drugs used in diabeties -> Blood glucose lowering drugs、excluding insulins -> Biguanides -> Antidiabetics、Methods of Manufacturing: By reaction of dimethylamine hydrochloride with dicyandiamide to yield the base.、Metformin hydrochloride、Preparation: ... J.J. Sterne、United States of America patent 3174901 (1965 to Jan Marcel Didier Aron-Samuel).、Metformin、Formulations、Preparations: Table: Metformin Hydrochloride Preparations [Table#6700]、Table: Metformin Hydrochloride Combinations Preparations [Table#6701] |
登记用途：Uses: MEDICATION (VET)、MEDICATION、Hypoglycemic Agents、Use (kg) in Switzerland (2009): >75000、Use (kg、approx.) in Germany (2009): >1000000、Use (kg) in USA (2002): 1450000、Use (kg) in France (2004): 716858、Consumption (g per capita) in Switzerland (2009): 9.6、Consumption (g per capita、approx.) in Germany (2009): 12、Consumption (g per capita) in the USA (2002): 5.1、Consumption (g per capita) in France (2004): 12、Excretion rate: 1、Calculated removal (%): 75.1、For use as an adjunct to diet and exercise in adult patients (18 years and older) with NIDDM. May also be used for the management of metabolic and reproductive abnormalities associated with polycystic ovary syndrome (PCOS). Jentadueto is for the treatment of patients when both linagliptin and metformin is appropriate.、Use Classification: Pharmaceuticals -> Alimentary tract and metabolism -> Drugs used in diabeties -> Blood glucose lowering drugs、excluding insulins -> Biguanides -> Antidiabetics、Methods of Manufacturing: By reaction of dimethylamine hydrochloride with dicyandiamide to yield the base.、Metformin hydrochloride、Preparation: ... J.J. Sterne、United States of America patent 3174901 (1965 to Jan Marcel Didier Aron-Samuel).、Metformin、Formulations、Preparations: Table: Metformin Hydrochloride Preparations [Table#6700]、Table: Metformin Hydrochloride Combinations Preparations [Table#6701]。
二甲双胍 是一种化工化合物，登记 CAS 号为 657-24-9，分子式 C4H11N5（分子量 129.16）。
登记 CAS 号：657-24-9
其分子式 C4H11N5 由 4 个碳、11 个氢、5 个氮 组成。
别名/同义词：二甲双胍 · Metformin
二甲双胍 的 CAS 登记号为 657-24-9。
分子式 C4H11N5，分子量 129.16。
别名/同义词：二甲双胍、Metformin。
登记用途：Uses: MEDICATION (VET)、MEDICATION、Hypoglycemic Agents、Use (kg) in Switzerland (2009): >75000、Use (kg、approx.) in Germany (2009): >1000000、Use (kg) in USA (2002): 1450000、Use (kg) in France (2004): 716858、Consumption (g per capita) in Switzerland (2009): 9.6、Consumption (g per capita、approx.) in Germany (2009): 12、Consumption (g per capita) in the USA (2002): 5.1、Consumption (g per capita) in France (2004): 12、Excretion rate: 1、Calculated removal (%): 75.1、For use as an adjunct to diet and exercise in adult patients (18 years and older) with NIDDM. May also be used for the management of metabolic and reproductive abnormalities associated with polycystic ovary syndrome (PCOS). Jentadueto is for the treatment of patients when both linagliptin and metformin is appropriate.、Use Classification: Pharmaceuticals -> Alimentary tract and metabolism -> Drugs used in diabeties -> Blood glucose lowering drugs、excluding insulins -> Biguanides -> Antidiabetics、Methods of Manufacturing: By reaction of dimethylamine hydrochloride with dicyandiamide to yield the base.、Metformin hydrochloride、Preparation: ... J.J. Sterne、United States of America patent 3174901 (1965 to Jan Marcel Didier Aron-Samuel).、Metformin、Formulations、Preparations: Table: Metformin Hydrochloride Preparations [Table#6700]、Table: Metformin Hydrochloride Combinations Preparations [Table#6701]。
二甲双胍（CAS 657-24-9）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 657-24-9 |
|---|---|
| PubChem CID | 4091 |
| Molecular formula | C4H11N5 |
| IUPAC name | 3-(diaminomethylidene)-1,1-dimethylguanidine |
| UNII (FDA) | 9100L32L2N |
| Molecular Weight | 129.16 |
|---|---|
| XLogP3 | -1.3 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 2 |
| Exact Mass | 129.10144537 |
| Monoisotopic Mass | 129.10144537 |
| Topological Polar Surface Area | 91.5 |
| Heavy Atom Count | 9 |
| Boiling Point | 224.1ºC at 760 mmHg |
|---|---|
| Melting Point | 223-226 °C |
| Melting Point | 223 - 226 °C |
| LogP | -2.6 |
| Ionization Efficiency | 3.49 |
| Ionization Efficiency | 2.7 |
| Ionization Efficiency | MeCN (80%) |
| Dissociation Constants | 12.4 |
metformin; 657-24-9; 1,1-Dimethylbiguanide; N,N-dimethylimidodicarbonimidic diamide; Metiguanide; Dimethylbiguanide; Metformine; N,N-Dimethylbiguanide; Metformina; N1,N1-Dimethylbiguanide; N,N-Dimethyldiguanide; 3-(diaminomethylidene)-1,1-dimethylguanidine; Diaformin; Dimethylbiguanid; Metformin extended release; BIGUANIDE, 1,1-DIMETHYL-
| GHS notification summary | 50% (2 / 4) |
|---|
| GHS notification summary | 50% (2 / 4) |
|---|---|
| Reported hazard statements | H302 (50%), H315, H319 |
This chemical does not meet GHS hazard criteria for 50% (2 of 4) of reports.
H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
Metformin · CAS 657-24-9 · C4H11N5. UNII 9100L32L2N. Boiling Point: 224.1ºC at 760 mmHg; Melting Point: 223-226 °C; Melting Point: 223 - 226 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Metformin