Magnesium Stearate (CAS 557-04-0) — formula C36H70MgO4, molecular weight 590.51 g/mol; category chemical.
| CAS Number | 557-04-0 |
|---|---|
| Molecular Formula | C36H70MgO4 |
| Molecular Weight | 590.51 g/mol |
| Melting Point | 88.5 °C (pure) |
| Applications | Uses: CIR ingredient: Magnesium Stearate, Used in cosmetics, pharmaceuticals, waterproofing agents, plastic stabilizers, emulsifiers, and rubber lubricants and dusting agents, Stearic acid occurs naturally in human and animal fats and oils and in some vegetable oils, including cocoa oil. Stearic acid can be prepared from animal fat (triglyceride) by treating with water at high temperature, leading to hydrolysis of triglycerides, or by hydrogenation of unsaturated vegetable oils such as cottonseed oil. [ACGIH], Used in baby dusting powders, as lubricant for plastics, as emulsifying agent in cosmetics, as drier in paints and varnishes, as flatting agent, as anticaking agent in foods and fire extinguishers, and as lubricant in making pharmaceutical tablets, [HSDB], Painting (Pigments, Binders, and Biocides) [Category: Paint], Firefighting [Category: Other], IN BABY DUSTING POWDERS, Dusting powder, lubricant for plastics, emulsifying agent in cosmetics, drier in paints and varnishes and flatting agent., COSMETICS INGREDIENT, ANTICAKING AGENT IN FOODS AND FIRE EXTINGUISHERS, RELEASE AGENT IN FOODS, LUBRICANT IN PHARMACEUTICAL TABLET MFR, Magnesium stearate is frequently used as a filler material and binder in drug tablets and as either inert binder or emulsification agent in cleansing products and cosmetics, respectively., PHARMACEUTICAL NECESSITY (LUBRICANT) IN MFR OF COMPRESSED TABLETS & IN BABY DUSTING POWDERS., Use Classification: EPA Safer Chemical Functional Use Classes -> Surfactants, Safer Chemical Classes -> Green half-circle - The chemical is expected to be of low concern, Food Additives -> ANTICAKING_AGENT, EMULSIFIER, Food Additives -> -> JECFA Functional Classes, Cosmetics -> Moisturising, Bulking, Anticaking, Cosmetic colorant, Industry Uses: Flame retardant, Sealant (barrier), Not Known or Reasonably Ascertainable, Processing aids not otherwise specified, Other, Lubricating agent, Consumer Uses: Flame retardant, Household Products: Information on 42 consumer products that contain Magnesium stearate in the following categories is provided:, • Inside the Home, • Personal Care, • Pet Care, Methods of Manufacturing: REACTION OF SODIUM STEARATE WITH MAGNESIUM SULFATE, Impurities: contains small amounts of the oleate and 7% magnesium oxide., technical grade, Formulations, Preparations: MAGNESIUM STEARATE, IS, COMPD OF MAGNESIUM WITH MIXTURE OF SOLID ORG ACIDS OBTAINED FROM FATS, & CONSISTS CHIEFLY OF VARIABLE PROPORTIONS OF MAGNESIUM STEARATE & MAGNESIUM PALMITATE. IT CONTAINS EQUIVALENT OF 6.8-8.0% OF MAGNESIUM OXIDE (40.30)., GRADES: TECHNICAL, USP FCC., A TYPICAL DRY COMPRESSED ANTIPERSPIRANT STICK, CONTAINS, 0.25 wt% MAGNESIUM STEARATE, U.S. Production: 2023: 2, 500, 000 - <4, 000, 000 lb, 2022: 4, 000 - <5, 2021: 2, 2020: 2, (1972) 2.16X10+9 GRAMS, (1975) 1.79X10+9 GRAMS, (1984) 1.08X10+10 g, General Manufacturing Information: Plastics Material and Resin Manufacturing, Paint and Coating Manufacturing, All Other Chemical Product and Preparation Manufacturing, Food, beverage, and tobacco product manufacturing, Textiles, apparel, and leather manufacturing, Pharmaceutical and Medicine Manufacturing, Custom Compounding of Purchased Resins, Plastics Product Manufacturing, Synthetic Rubber Manufacturing, Octadecanoic acid, magnesium salt (2:1): ACTIVE, The more important dusting powders include ... magnesium stearate, NF ..., Microspheres containing the mucoadhesive polymer chitosan hydrochloride, with matrix polymer Eudragit RS, pipemidic acid as a model drug and agglomeration preventing agent magnesium stearate were prepared by the solvent evaporation method. The amount of magnesium stearate was varied and the following methods were used for microsphere evaluation: sieve analysis, drug content and dissolution determination, scanning electron microscopy, x-ray diffractometry, DSC and FTIR spectroscopy. The results showed that average particle size decreased with increasing amount of magnesium stearate used for microsphere preparation. This is probably a consequence of stabilization of the emulsion droplets with magnesium stearate. Higher pipemidic acid content in the microspheres was observed in larger particle size fractions and when higher amounts of magnesium stearate were used. It was also found that these two parameters significantly influenced the dissolution rate. The important reason for the differences in drug content in microspheres of different particle sizes is the diffusion of pipemidic acid from the acetone droplets in liquid paraffin during the preparation procedure. The physical state of pipemidic acid changed from crystalline to mostly amorphous with its incorporation in microspheres, as shown by x-ray diffractometry and differential scanning calorimetry. No differences were observed in the physical state of pipemidic acid and in microsphere shape and surface between different size fractions of microspheres, prepared with different amounts of magnesium stearate. Additionally, no correlation between the physical state of the drug in different microspheres and their biopharmaceutical properties was found. |
| Category | Anti-caking Agents |
Documented applications: Uses: CIR ingredient: Magnesium Stearate, Used in cosmetics, pharmaceuticals, waterproofing agents, plastic stabilizers, emulsifiers, and rubber lubricants and dusting agents, Stearic acid occurs naturally in human and animal fats and oils and in some vegetable oils, including cocoa oil. Stearic acid can be prepared from animal fat (triglyceride) by treating with water at high temperature, leading to hydrolysis of triglycerides, or by hydrogenation of unsaturated vegetable oils such as cottonseed oil. [ACGIH], Used in baby dusting powders, as lubricant for plastics, as emulsifying agent in cosmetics, as drier in paints and varnishes, as flatting agent, as anticaking agent in foods and fire extinguishers, and as lubricant in making pharmaceutical tablets, [HSDB], Painting (Pigments, Binders, and Biocides) [Category: Paint], Firefighting [Category: Other], IN BABY DUSTING POWDERS, Dusting powder, lubricant for plastics, emulsifying agent in cosmetics, drier in paints and varnishes and flatting agent., COSMETICS INGREDIENT, ANTICAKING AGENT IN FOODS AND FIRE EXTINGUISHERS, RELEASE AGENT IN FOODS, LUBRICANT IN PHARMACEUTICAL TABLET MFR, Magnesium stearate is frequently used as a filler material and binder in drug tablets and as either inert binder or emulsification agent in cleansing products and cosmetics, respectively., PHARMACEUTICAL NECESSITY (LUBRICANT) IN MFR OF COMPRESSED TABLETS & IN BABY DUSTING POWDERS., Use Classification: EPA Safer Chemical Functional Use Classes -> Surfactants, Safer Chemical Classes -> Green half-circle - The chemical is expected to be of low concern, Food Additives -> ANTICAKING_AGENT, EMULSIFIER, Food Additives -> -> JECFA Functional Classes, Cosmetics -> Moisturising, Bulking, Anticaking, Cosmetic colorant, Industry Uses: Flame retardant, Sealant (barrier), Not Known or Reasonably Ascertainable, Processing aids not otherwise specified, Other, Lubricating agent, Consumer Uses: Flame retardant, Household Products: Information on 42 consumer products that contain Magnesium stearate in the following categories is provided:, • Inside the Home, • Personal Care, • Pet Care, Methods of Manufacturing: REACTION OF SODIUM STEARATE WITH MAGNESIUM SULFATE, Impurities: contains small amounts of the oleate and 7% magnesium oxide., technical grade, Formulations, Preparations: MAGNESIUM STEARATE, IS, COMPD OF MAGNESIUM WITH MIXTURE OF SOLID ORG ACIDS OBTAINED FROM FATS, & CONSISTS CHIEFLY OF VARIABLE PROPORTIONS OF MAGNESIUM STEARATE & MAGNESIUM PALMITATE. IT CONTAINS EQUIVALENT OF 6.8-8.0% OF MAGNESIUM OXIDE (40.30)., GRADES: TECHNICAL, USP FCC., A TYPICAL DRY COMPRESSED ANTIPERSPIRANT STICK, CONTAINS, 0.25 wt% MAGNESIUM STEARATE, U.S. Production: 2023: 2, 500, 000 - <4, 000, 000 lb, 2022: 4, 000 - <5, 2021: 2, 2020: 2, (1972) 2.16X10+9 GRAMS, (1975) 1.79X10+9 GRAMS, (1984) 1.08X10+10 g, General Manufacturing Information: Plastics Material and Resin Manufacturing, Paint and Coating Manufacturing, All Other Chemical Product and Preparation Manufacturing, Food, beverage, and tobacco product manufacturing, Textiles, apparel, and leather manufacturing, Pharmaceutical and Medicine Manufacturing, Custom Compounding of Purchased Resins, Plastics Product Manufacturing, Synthetic Rubber Manufacturing, Octadecanoic acid, magnesium salt (2:1): ACTIVE, The more important dusting powders include ... magnesium stearate, NF ..., Microspheres containing the mucoadhesive polymer chitosan hydrochloride, with matrix polymer Eudragit RS, pipemidic acid as a model drug and agglomeration preventing agent magnesium stearate were prepared by the solvent evaporation method. The amount of magnesium stearate was varied and the following methods were used for microsphere evaluation: sieve analysis, drug content and dissolution determination, scanning electron microscopy, x-ray diffractometry, DSC and FTIR spectroscopy. The results showed that average particle size decreased with increasing amount of magnesium stearate used for microsphere preparation. This is probably a consequence of stabilization of the emulsion droplets with magnesium stearate. Higher pipemidic acid content in the microspheres was observed in larger particle size fractions and when higher amounts of magnesium stearate were used. It was also found that these two parameters significantly influenced the dissolution rate. The important reason for the differences in drug content in microspheres of different particle sizes is the diffusion of pipemidic acid from the acetone droplets in liquid paraffin during the preparation procedure. The physical state of pipemidic acid changed from crystalline to mostly amorphous with its incorporation in microspheres, as shown by x-ray diffractometry and differential scanning calorimetry. No differences were observed in the physical state of pipemidic acid and in microsphere shape and surface between different size fractions of microspheres, prepared with different amounts of magnesium stearate. Additionally, no correlation between the physical state of the drug in different microspheres and their biopharmaceutical properties was found..
Magnesium Stearate is a chemical compound with CAS registry number 557-04-0 and molecular formula C36H70MgO4 (molecular weight 590.51 g/mol), belonging to the chemical segment of chemical raw materials.
CAS number: 557-04-0
Its molecular formula C36H70MgO4 comprises 36 C, 70 H, 1 Mg, 4 O atoms.
Also known as: Magnesium Stearate · MAGNESIUM STEARATE USP · MAGNESIUM STEARATE NF
Category: chemical
The CAS registry number of Magnesium Stearate is 557-04-0.
Molecular formula C36H70MgO4, molecular weight 590.51 g/mol.
It is also registered under: Magnesium Stearate, MAGNESIUM STEARATE USP, MAGNESIUM STEARATE NF.
Recorded applications: Uses: CIR ingredient: Magnesium Stearate, Used in cosmetics, pharmaceuticals, waterproofing agents, plastic stabilizers, emulsifiers, and rubber lubricants and dusting agents, Stearic acid occurs naturally in human and animal fats and oils and in some vegetable oils, including cocoa oil. Stearic acid can be prepared from animal fat (triglyceride) by treating with water at high temperature, leading to hydrolysis of triglycerides, or by hydrogenation of unsaturated vegetable oils such as cottonseed oil. [ACGIH], Used in baby dusting powders, as lubricant for plastics, as emulsifying agent in cosmetics, as drier in paints and varnishes, as flatting agent, as anticaking agent in foods and fire extinguishers, and as lubricant in making pharmaceutical tablets, [HSDB], Painting (Pigments, Binders, and Biocides) [Category: Paint], Firefighting [Category: Other], IN BABY DUSTING POWDERS, Dusting powder, lubricant for plastics, emulsifying agent in cosmetics, drier in paints and varnishes and flatting agent., COSMETICS INGREDIENT, ANTICAKING AGENT IN FOODS AND FIRE EXTINGUISHERS, RELEASE AGENT IN FOODS, LUBRICANT IN PHARMACEUTICAL TABLET MFR, Magnesium stearate is frequently used as a filler material and binder in drug tablets and as either inert binder or emulsification agent in cleansing products and cosmetics, respectively., PHARMACEUTICAL NECESSITY (LUBRICANT) IN MFR OF COMPRESSED TABLETS & IN BABY DUSTING POWDERS., Use Classification: EPA Safer Chemical Functional Use Classes -> Surfactants, Safer Chemical Classes -> Green half-circle - The chemical is expected to be of low concern, Food Additives -> ANTICAKING_AGENT, EMULSIFIER, Food Additives -> -> JECFA Functional Classes, Cosmetics -> Moisturising, Bulking, Anticaking, Cosmetic colorant, Industry Uses: Flame retardant, Sealant (barrier), Not Known or Reasonably Ascertainable, Processing aids not otherwise specified, Other, Lubricating agent, Consumer Uses: Flame retardant, Household Products: Information on 42 consumer products that contain Magnesium stearate in the following categories is provided:, • Inside the Home, • Personal Care, • Pet Care, Methods of Manufacturing: REACTION OF SODIUM STEARATE WITH MAGNESIUM SULFATE, Impurities: contains small amounts of the oleate and 7% magnesium oxide., technical grade, Formulations, Preparations: MAGNESIUM STEARATE, IS, COMPD OF MAGNESIUM WITH MIXTURE OF SOLID ORG ACIDS OBTAINED FROM FATS, & CONSISTS CHIEFLY OF VARIABLE PROPORTIONS OF MAGNESIUM STEARATE & MAGNESIUM PALMITATE. IT CONTAINS EQUIVALENT OF 6.8-8.0% OF MAGNESIUM OXIDE (40.30)., GRADES: TECHNICAL, USP FCC., A TYPICAL DRY COMPRESSED ANTIPERSPIRANT STICK, CONTAINS, 0.25 wt% MAGNESIUM STEARATE, U.S. Production: 2023: 2, 500, 000 - <4, 000, 000 lb, 2022: 4, 000 - <5, 2021: 2, 2020: 2, (1972) 2.16X10+9 GRAMS, (1975) 1.79X10+9 GRAMS, (1984) 1.08X10+10 g, General Manufacturing Information: Plastics Material and Resin Manufacturing, Paint and Coating Manufacturing, All Other Chemical Product and Preparation Manufacturing, Food, beverage, and tobacco product manufacturing, Textiles, apparel, and leather manufacturing, Pharmaceutical and Medicine Manufacturing, Custom Compounding of Purchased Resins, Plastics Product Manufacturing, Synthetic Rubber Manufacturing, Octadecanoic acid, magnesium salt (2:1): ACTIVE, The more important dusting powders include ... magnesium stearate, NF ..., Microspheres containing the mucoadhesive polymer chitosan hydrochloride, with matrix polymer Eudragit RS, pipemidic acid as a model drug and agglomeration preventing agent magnesium stearate were prepared by the solvent evaporation method. The amount of magnesium stearate was varied and the following methods were used for microsphere evaluation: sieve analysis, drug content and dissolution determination, scanning electron microscopy, x-ray diffractometry, DSC and FTIR spectroscopy. The results showed that average particle size decreased with increasing amount of magnesium stearate used for microsphere preparation. This is probably a consequence of stabilization of the emulsion droplets with magnesium stearate. Higher pipemidic acid content in the microspheres was observed in larger particle size fractions and when higher amounts of magnesium stearate were used. It was also found that these two parameters significantly influenced the dissolution rate. The important reason for the differences in drug content in microspheres of different particle sizes is the diffusion of pipemidic acid from the acetone droplets in liquid paraffin during the preparation procedure. The physical state of pipemidic acid changed from crystalline to mostly amorphous with its incorporation in microspheres, as shown by x-ray diffractometry and differential scanning calorimetry. No differences were observed in the physical state of pipemidic acid and in microsphere shape and surface between different size fractions of microspheres, prepared with different amounts of magnesium stearate. Additionally, no correlation between the physical state of the drug in different microspheres and their biopharmaceutical properties was found..
Category: Anti-caking Agents.
Independent reference data for Magnesium Stearate (CAS 557-04-0), compiled from public chemistry databases.
| CAS 号 | 557-04-0 |
|---|---|
| PubChem CID | 11177 |
| 分子式 | C36H70MgO4 |
| 分子量 | 590.51 g/mol |
| IUPAC 名称 | magnesium bis(octadecanoate) |
| InChIKey | HQKMJHAJHXVSDF-UHFFFAOYSA-L |
| UNII（FDA） | 70097M6I30 |
| ChEBI 编号 | CHEBI:9254 |
| Molecular Weight | 591.2 |
|---|---|
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 30 |
| Exact Mass | 590.5124524 |
| Monoisotopic Mass | 590.5124524 |
| Topological Polar Surface Area | 80.3 |
| Heavy Atom Count | 41 |
| Melting Point | 88.5 °C (pure) |
|---|---|
| Melting Point | MP: 132 °C /Technical/ |
| Melting Point | 88 °C |
| Solubility | IN 100 CC WATER: 0.003 G @ 15 °C; 0.004 G @ 25 °C; 0.008 G @ 50 °C |
| Density | 1.028 |
| Density | 1.02 g/cm³ |
| Color Additive Status | 172.863 |
| Color Additive Status | 173.340 |
| Color Additive Status | 175.300 |
| Color Additive Status | 181.29 |
MAGNESIUM STEARATE; 557-04-0; Magnesium distearate; Magnesium octadecanoate; Dibasic magnesium stearate; Octadecanoic acid, magnesium salt; Synpro 90; Stearic acid, magnesium salt; Petrac MG 20NF; Magnesium stearate g; Synpro Magnesium Stearate 90; Magnesii stearas; NP 1500; SM 1000; Octadecanoic acid, magnesium salt (2:1); CHEBI:9254
| 法规与食品接触 | FDA Substance added to food: ANTICAKING AGENT OR FREE-FLOW AGENT, DRYING AGENT, FORMULATION AID, HUMECTANT FDA 21 CFR 中列出的食品接触物质清单：FCS ANTICAKING_AGENT; EMULSIFIER; Food Additives ->: Food Additives NOT SPECIFIED Considered for specification only. TRS 1027-JECFA 89/42 |
|---|---|
| GHS 通报统计 | 54.9% (280 / 510) |
| GHS 通报统计 | 54.9% (280 / 510) |
|---|---|
| 已通报的危害声明 | H315 (22.4%), H319 (25.9%), H335 (22.7%), H413 (18.4%), H316, H320 |
Magnesium Stearate 的 CAS 号为 557-04-0，分子式 C36H70MgO4，分子量 590.51 g/mol。 UNII 70097M6I30; ChEBI 9254; InChIKey HQKMJHAJHXVSDF-UHFFFAOYSA-L. Melting Point: 88.5 °C (pure); Melting Point: MP: 132 °C /Technical/; Melting Point: 88 °C.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 硬脂酸镁 NF