依替膦酸二钠

Description

Disodium Etidronate (HEDP-Na2) · CAS 7414-83-7 · C2H6Na2O7P2. UNII M16PXG993G.

Identification

CAS Registry Number	7414-83-7
PubChem CID	23894
Molecular formula	C2H6Na2O7P2
IUPAC name	disodium;hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]ethyl]phosphinate
UNII (FDA)	M16PXG993G

Computed Descriptors

Molecular Weight	249.99
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	2
Exact Mass	249.93841509
Monoisotopic Mass	249.93841509
Topological Polar Surface Area	141
Heavy Atom Count	13
Formal Charge	0
Complexity	206

Regulatory Status

Regulatory & Food Contact	CIR / INCI: Cosmetic ingredients (Disodium Etidronate) -> CIR (Cosmetic Ingredient Review)
GHS notification summary	44.3% (143 / 323)

GHS Hazard Classification

GHS notification summary	44.3% (143 / 323)
Reported hazard statements	H302 (35.9%), H413 (17%), H319

Documented Uses

• CIR ingredient: Disodium Etidronate
• For the treatment of symptomatic Paget's disease of bone and in the prevention and treatment of heterotopic ossification following total hip replacement or due to spinal cord injury.
• Information on 1 consumer products that contain Disodium Etidronate in the following categories is provided:
• Phosphonic acid, P,P'-(1-hydroxyethylidene)bis-, sodium salt (1:2): ACTIVE
• Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.
• Not metabolized. Route of Elimination: Etidronate disodium is not metabolized. Within 24 hours, approximately half the absorbed dose is excreted in urine; the remainder is distributed to bone compartments from which it is slowly eliminated. Unabsorbed drug is excreted intact in the feces. Half Life: In normal subjects, plasma half-life of etidronic acid, based on non-compartmental pharmacokinetics is 1 to 6 hours.

Synonyms

Etidronate disodium; 7414-83-7; Disodium etidronate; Sodium etidronate; Disodium ethydronate; Sodium ethidronate; Sodium ethydronate; Etidronic Acid Disodium Salt; Turpinal 2NZ; Disodium ethanol-1,1-diphosphonate; DTXSID1029671; Disodium 1-hydroxyethylidene phosphonate; Disodium (1-hydroxyethylidene)diphosphonate; Disodium dihydrogen (1-hydroxyethylidene)diphosphonate; Disodium ethane-1-hydroxy-1,1-diphosphonate; Phosphonic acid, (1-hydroxyethylidene)bis-, disodium salt

Frequently Asked Questions

What are the CAS number and molecular formula of Disodium Etidronate (HEDP-Na2)?

CAS 7414-83-7; molecular formula C2H6Na2O7P2; molecular weight — g/mol.

What other names is Disodium Etidronate (HEDP-Na2) known by?

Etidronate disodium, 7414-83-7, Disodium etidronate, Sodium etidronate, Disodium ethydronate, Sodium ethidronate.

What is the regulatory status of Disodium Etidronate (HEDP-Na2)?

Documented regulatory listings: CIR / INCI: Cosmetic ingredients (Disodium Etidronate) -> CIR (Cosmetic Ingredient Review).

Is Disodium Etidronate (HEDP-Na2) classified as hazardous?

44.3% of GHS notifications report no hazard classification (143 of 323).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.