2-苯基苯并咪唑-5-磺酸

Description

Phenyl benzimidazole sulfonic acid · CAS 27503-81-7 · C13H10N2O3S. UNII 9YQ9DI1W42.

Identification

CAS Registry Number	27503-81-7
PubChem CID	33919
Molecular formula	C13H10N2O3S
IUPAC name	2-phenyl-3H-benzimidazole-5-sulfonic acid
UNII (FDA)	9YQ9DI1W42

Computed Descriptors

Molecular Weight	274.30
XLogP3	2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	274.04121336
Monoisotopic Mass	274.04121336
Topological Polar Surface Area	91.4
Heavy Atom Count	19
Formal Charge	0

Physical description & handling notes

• >300, decomposes at 410
• Soluble
• Ensulizole is a selective UV-B filter with little activity against UV-A wavelengths. _In vitro_, ensulizole oxidizes guanine bases upon photoexcitation by UV-B and may cause photodamage on DNA, proteins and lipids in the cellular context.

Regulatory Status

Regulatory & Food Contact	CIR / INCI: Uv filter; Uv absorber
GHS notification summary	86% (117 / 136)

GHS Hazard Classification

GHS notification summary	86% (117 / 136)
Reported hazard statements	H315 (14%), H319 (14%)

Documented Uses

• Cosmetics -> Uv filter; Uv absorber
• Information on 7 consumer products that contain Phenylbenzimidazole sulfonic acid in the following categories is provided:
• 1H-Benzimidazole-6-sulfonic acid, 2-phenyl-: ACTIVE
• Indicated to be used as an UV-B-absorbing molecule in sunscreen formulations.
• A 2025 review by authors in the U.S. and U.K. used experimentally determined values of 4% for oral absorption in rats and 0.26% for dermal absorption in humans for their risk calculation purposes. Also, the authors noted no evidence of bioaccumulation in rat vivo studies, which they stated is consistent with the high water solubility and low octanol/water partition coefficient.
• Ensulizole strongly absorbs UV-B wavelengths. It offers protection against UV-B-induced cyclobutane pyrimidine dimers. Based on the findings in vitro and in cellulo, ensulizole induces damage on the DNA, causes DNA strand breaks and photosensitizes the formation of oxidized guanines via type I and II photosensitization mechanisms following UV-A or UV-B irradiation. Ensulizole is capable of generating reactive oxygen species, including singlet oxygen upon photoexcitation.

Synonyms

Ensulizole; 27503-81-7; 2-PHENYLBENZIMIDAZOLE-5-SULFONIC ACID; Phenylbenzimidazole sulfonic acid; ensulizol; DTXSID3038852; 9YQ9DI1W42; 1H-Benzimidazole-5-sulfonic acid-2-phenyl-; DTXCID1018852; 2-phenyl-1H-1,3-benzodiazole-6-sulfonic acid; ensulizolum; novantisol; RefChem:55096; Covergirl Outlast Stay Fabulous 3in1 Foundation; FULL SPECTRUM MATTE AMBITION SKIN PRIMER SPF 20; Covergirl Queen Collection All Day Flawless 3in1 Foundation

Frequently Asked Questions

What are the CAS number and molecular formula of Phenyl benzimidazole sulfonic acid?

CAS 27503-81-7; molecular formula C13H10N2O3S; molecular weight — g/mol.

What other names is Phenyl benzimidazole sulfonic acid known by?

Ensulizole, 27503-81-7, 2-PHENYLBENZIMIDAZOLE-5-SULFONIC ACID, Phenylbenzimidazole sulfonic acid, ensulizol, DTXSID3038852.

What is the regulatory status of Phenyl benzimidazole sulfonic acid?

Documented regulatory listings: CIR / INCI: Uv filter; Uv absorber.

Is Phenyl benzimidazole sulfonic acid classified as hazardous?

86% of GHS notifications report no hazard classification (117 of 136).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.