6-氯-α-甲基-9H-咔唑-2-乙酸

Description

6-chloro-α-methyl-9H-carbazole-2-acetic acid · CAS 53716-49-7 · C15H12ClNO2. UNII FFL0D546HO. Melting Point: 195-199; Melting Point: 197.5 °C; Solubility: 3.79e-03 g/L.

Identification

CAS Registry Number	53716-49-7
PubChem CID	2581
Molecular formula	C15H12ClNO2
IUPAC name	2-(6-chloro-9H-carbazol-2-yl)propanoic acid
UNII (FDA)	FFL0D546HO

Computed Descriptors

Molecular Weight	273.71
XLogP3	4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	273.0556563
Monoisotopic Mass	273.0556563
Topological Polar Surface Area	53.1
Heavy Atom Count	19
Formal Charge	0

Physical & Chemical Properties

Melting Point	195-199
Melting Point	197.5 °C
Solubility	3.79e-03 g/L
LogP	3.8
LogP	4.04

Physical description & handling notes

• Solid
• Practically insoluble at 25 °C
• >41.1 [ug/mL] (The mean of the results at pH 7.4)
• 156.1 Ų [M+H]+ [CCS Type: TW]
• 161.46 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• Carprofen is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class that includes ibuprofen, naproxen, and ketoprofen. It is no longer used in the clinical setting, but is approved for use in dogs. Carprofen is non-narcotic and has characteristic analgesic and antipyretic activity approximately equipotent to indomethacin in animal models.

Regulatory Status

GHS notification summary	2% (1 / 50)

GHS Hazard Classification

GHS notification summary	2% (1 / 50)
Reported hazard statements	H301 (98%)

Documented Uses

• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• Pharmaceuticals -> Animal Drugs -> Approved in Taiwan
• For use as a pain reliever in the treatment of joint pain and post-surgical pain.
• Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
• Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms.
• QM01 - Antiinflammatory and antirheumatic products

Synonyms

carprofen; 53716-49-7; 2-(6-Chloro-9H-carbazol-2-yl)propanoic acid; Rimadyl; Carprofeno; 6-Chloro-alpha-methyl-9H-carbazole-2-acetic acid; Carprofene; Carprofenum; Carprodyl; 6-Chloro-alpha-methylcarbazole-2-acetic acid; Ro 20-5720/000; DTXSID1045871; Ro-20-5720/000; Rimadyl Caplets; (+-)-6-Chloro-alpha-methylcarbazole-2-acetic acid; Carprofen for veterinary use

Frequently Asked Questions

What are the CAS number and molecular formula of 6-chloro-α-methyl-9H-carbazole-2-acetic acid?

CAS 53716-49-7; molecular formula C15H12ClNO2; molecular weight — g/mol.

What other names is 6-chloro-α-methyl-9H-carbazole-2-acetic acid known by?

carprofen, 53716-49-7, 2-(6-Chloro-9H-carbazol-2-yl)propanoic acid, Rimadyl, Carprofeno, 6-Chloro-alpha-methyl-9H-carbazole-2-acetic acid.

Is 6-chloro-α-methyl-9H-carbazole-2-acetic acid classified as hazardous?

2% of GHS notifications report no hazard classification (1 of 50).

What are the key physical properties of 6-chloro-α-methyl-9H-carbazole-2-acetic acid?

Melting Point: 195-199; Melting Point: 197.5 °C; Solubility: 3.79e-03 g/L; LogP: 3.8.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.