L-焦谷氨酸

Description

L-Pyroglutamic Acid · CAS 98-79-3 · C5H7NO3. UNII SZB83O1W42. Melting Point: 184.7; Solubility: 476000; Solubility: 476.0 mg/mL at 13 °C.

Identification

CAS Registry Number	98-79-3
PubChem CID	7405
Molecular formula	C5H7NO3
IUPAC name	(2S)-5-oxopyrrolidine-2-carboxylic acid
UNII (FDA)	SZB83O1W42

Computed Descriptors

Molecular Weight	129.11
XLogP3	-0.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Exact Mass	129.042593085
Monoisotopic Mass	129.042593085
Topological Polar Surface Area	66.4
Heavy Atom Count	9
Formal Charge	0

Physical & Chemical Properties

Melting Point	184.7
Solubility	476000
Solubility	476.0 mg/mL at 13 °C
Collision Cross Section	124.6 Ų [M-H]-
Collision Cross Section	130.6 Ų [M+H]+

Physical description & handling notes

• Solid; [Merck Index] White crystalline powder; [Alfa Aesar MSDS]
• Solid
• >19.4 [ug/mL] (The mean of the results at pH 7.4)
• 121 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine]
• 130.6 Ų [M+H]+ [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]
• 130.3 Ų [M+H]+ [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]

Regulatory Status

Regulatory & Food Contact	CIR / INCI: Moisturising; Humectant
GHS notification summary	1.5% (5 / 343)

GHS Hazard Classification

GHS notification summary	1.5% (5 / 343)
Reported hazard statements	H315 (21.9%), H318 (78.1%), H319 (20.4%), H335 (21.6%)

Documented Uses

• A cyclized internal amide of L-glutamic acid; Occurs naturally in vegetables, fruits, grasses, and molasses; [Merck Index]
• This is an endogenously produced metabolite found in the human body. It is used in metabolic reactions, catabolic reactions or waste generation.
• Cosmetics -> Moisturising; Humectant
• Agriculture, Forestry, Fishing and Hunting
• In skin conditioning agents, it has been observed that the percutaneous absorption of 5, 10, and 20% sodium pidolic acid through human skin was 5.97, 6.78, and 5.89%, respectively.
• In the dog animal model, it was determined that 30% of an absorbed oral administration of pidolic acid was excreted unchanged in the urine and the remainder converted to urea.

Synonyms

L-Pyroglutamic acid; 98-79-3; Pyroglutamic acid; Pidolic acid; 5-oxo-L-proline; (2S)-5-oxopyrrolidine-2-carboxylic acid; pyroglu; GLUTIMIC ACID; (S)-(-)-2-Pyrrolidone-5-carboxylic acid; 5-L-Oxoproline; L-Proline, 5-oxo-; L-5-Oxoproline; Pidolidone; (S)-PYROGLUTAMIC ACID; AJIDEW A-100; (-)-2-Pyrrolidone-5-carboxylic acid

Frequently Asked Questions

What are the CAS number and molecular formula of L-Pyroglutamic Acid?

CAS 98-79-3; molecular formula C5H7NO3; molecular weight — g/mol.

What other names is L-Pyroglutamic Acid known by?

L-Pyroglutamic acid, 98-79-3, Pyroglutamic acid, Pidolic acid, 5-oxo-L-proline, (2S)-5-oxopyrrolidine-2-carboxylic acid.

What is the regulatory status of L-Pyroglutamic Acid?

Documented regulatory listings: CIR / INCI: Moisturising; Humectant.

Is L-Pyroglutamic Acid classified as hazardous?

1.5% of GHS notifications report no hazard classification (5 of 343).

What are the key physical properties of L-Pyroglutamic Acid?

Melting Point: 184.7; Solubility: 476000; Solubility: 476.0 mg/mL at 13 °C; Collision Cross Section: 124.6 Ų [M-H]-.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.