Zafirlukast

Description

Zafirlukast · CAS 107753-78-6 · C31H33N3O6S. UNII XZ629S5L50. Melting Point: 139; Melting Point: 139 °C; Solubility: 9.62e-04 g/L.

Identification

CAS Registry Number	107753-78-6
PubChem CID	5717
Molecular formula	C31H33N3O6S
IUPAC name	cyclopentyl N-[3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-methylindol-5-yl]carbamate
UNII (FDA)	XZ629S5L50

Computed Descriptors

Molecular Weight	575.7
XLogP3	5.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	9
Exact Mass	575.20900695
Monoisotopic Mass	575.20900695
Topological Polar Surface Area	124
Heavy Atom Count	41
Formal Charge	0

Physical & Chemical Properties

Melting Point	139
Melting Point	139 °C
Solubility	9.62e-04 g/L
LogP	5.4

Physical description & handling notes

• Solid

GHS Hazard Classification

Reported hazard statements	H413 (92.9%)

Documented Uses

• For the prophylaxis and chronic treatment of asthma.
• Zafirlukast belongs to the leukotriene receptor antagonist (LTRA) class of medications and is available in strengths of 10 mg and 20 mg chewable tablets for oral administration. The U.S. Food and Drug Administration (FDA) approved the medication for managing chronic asthma in adults and children 5 or older. Zafirlukast is also used as an off-label drug to manage chronic urticaria, prevent exercise-induced bronchospasm, and treat allergic rhinitis in patients.
• Zafirlukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma. Zafirlukast has been linked to rare, but occasionally severe cases of acute liver injury.
• Breast Feeding; Lactation; Milk, Human; Anti-Asthmatic Agents; Leukotriene Antagonists
• Take on an empty stomach. Take at least 1 hour before or 2 hours after meals.
• Drugs that are used to treat asthma.

Synonyms

zafirlukast; 107753-78-6; Accolate; ICI-204219; ICI 204,219; ICI 204219; DTXSID5023746; Cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carbamoyl)benzyl)-1-methylindole-5-carbamate; XZ629S5L50; ICI-204,219; 4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide; DTXCID303746; CHEBI:10100; cyclopentyl 3-[2-methoxy-4-[(o-tolylsulfonyl)carbamoyl]benzyl]-1-methylindole-5-carbamate; zafirlukastum; 4-(5-cyclopentyloxycarbonylamino-2-methylindol-3-yl-methyl)-3-methoxy-N-O-tolylsulfonylbenzamide

Frequently Asked Questions

What are the CAS number and molecular formula of Zafirlukast?

CAS 107753-78-6; molecular formula C31H33N3O6S; molecular weight — g/mol.

What other names is Zafirlukast known by?

zafirlukast, 107753-78-6, Accolate, ICI-204219, ICI 204,219, ICI 204219.

Is Zafirlukast classified as hazardous?

Hazard statements reported: H413.

What are the key physical properties of Zafirlukast?

Melting Point: 139; Melting Point: 139 °C; Solubility: 9.62e-04 g/L; LogP: 5.4.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.