替硝唑

Description

tinidazole · CAS 19387-91-8 · C8H13N3O4S. UNII 033KF7V46H. Melting Point: 127-128 °C; Melting Point: 127 - 128 °C; Solubility: 19900.

Identification

CAS Registry Number	19387-91-8
PubChem CID	5479
Molecular formula	C8H13N3O4S
IUPAC name	1-(2-ethylsulfonylethyl)-2-methyl-5-nitroimidazole
UNII (FDA)	033KF7V46H

Computed Descriptors

Molecular Weight	247.27
XLogP3	-0.4
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	247.06267708
Monoisotopic Mass	247.06267708
Topological Polar Surface Area	106
Heavy Atom Count	16
Formal Charge	0

Physical & Chemical Properties

Melting Point	127-128 °C
Melting Point	127 - 128 °C
Solubility	19900
Solubility	3.03e+00 g/L
LogP	-0.35
LogP	log Kow = -0.35
LogP	0.7
LogP	-0.38

Physical description & handling notes

• Solid
• Colorless crystals from benzene
• >37.1 [ug/mL] (The mean of the results at pH 7.4)
• 149.7 Ų [M+H]+ [CCS Type: TW; Method: calibrated with Waters Major Mix]
• 161.2 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with Waters Major Mix]
• Tinidazole is a synthetic antiprotozoal agent. Tinidazole demonstrates activity both in vitro and in clinical infections against the following protozoa: <i>Trichomonas vaginalis</i>, <i>Giardia duodenalis</i> (also termed <i>G. lamblia</i>), and <i>Entamoeba histolytica</i>. Tinidazole does not appear to have activity against most strains of vaginal lactobacilli.

GHS Hazard Classification

Reported hazard statements	H312 (56.8%), H332 (58.1%), H341 (56.8%), H351 (97.3%), H361 (40.5%)

Documented Uses

• Antiprotozoal and antibacterial activity
• Pharmaceuticals -> Animal Drugs -> Approved in Taiwan
• Synthesis: heating 2-methyl-5-nitroimidazole with 2-ethylsulfonylethyl-4-toluenesulfonate for 4 h
• For the treatment of trichomoniasis caused by T. vaginalis in both female and male patients. Also for the treatment of giardiasis caused by G. duodenalis in both adults and pediatric patients older than three years of age and for the treatment of intestinal amebiasis and amebic liver abscess caused by E. histolytica in both adults and pediatric patients older than three years of age.
• Tinidazole is an orally available, broad spectrum antimicrobial agent used in the treatment of bacterial, protozoal and parasitic infections. Tinidazole is a nitroimidazole similar to metronidazole and is likely to have a similar spectrum and frequency of side effects, including a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Anti-Infective Agents; Antibacterial Agents; Antiprotozoal Agents; Nitroimidazoles

Synonyms

tinidazole; 19387-91-8; Fasigyn; Trimonase; Fasigin; Tricolam; 1-(2-(Ethylsulfonyl)ethyl)-2-methyl-5-nitro-1H-imidazole; Simplotan; Tinidazol; Sorquetan; Haisigyn; Tinidazolum; 1-(2-ethylsulfonylethyl)-2-methyl-5-nitroimidazole; Pletil; CP 12574; timidazole

Frequently Asked Questions

What are the CAS number and molecular formula of tinidazole?

CAS 19387-91-8; molecular formula C8H13N3O4S; molecular weight — g/mol.

What other names is tinidazole known by?

tinidazole, 19387-91-8, Fasigyn, Trimonase, Fasigin, Tricolam.

Is tinidazole classified as hazardous?

Hazard statements reported: H312, H332, H341, H351, H361.

What are the key physical properties of tinidazole?

Melting Point: 127-128 °C; Melting Point: 127 - 128 °C; Solubility: 19900; Solubility: 3.03e+00 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.