氧氟沙星（CAS 82419-36-1）：分子式 C18H20FN3O4、分子量 361.4。
| CAS号 | 82419-36-1 |
|---|---|
| 分子式 | C18H20FN3O4 |
| 分子量 | 361.4 |
| 熔点 | 254 |
| LogP | -0.39 |
| 应用领域 | Uses: MEDICATION、Use (kg、approx.) in Germany (2009): >1000、exact) in Germany (2009): 1202、Use (kg) in France (2004): 4137、Consumption (g per capita、approx.) in Germany (2009): 0.0122、exact) in Germany (2009): 0.0147、Consumption (g per capita) in France (2004): 0.0685、Excretion rate: 0.88、Calculated removal (%): 1.9、For the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms: <i>Corynebacterium<、i> species、<i>Staphylococus aureus<、i>、<i>Staphylococcus epidermidis<、<i>Streptococcus pneumoniae<、<i>Streptococcus<、i> (Groups C、F、G)、Viridans group streptococci、<i>Acinetobacter lwoffii<、<i>Haemophilus influenzae<、<i>Serratia marcescens<、i>. Levofloxacin is a synthetic chemotherapeutic agent used to treat severe and life threatening bacterial infection (L1009).、Use Classification: Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: Preparation: I. Hayakawa et al.、EP 47005、eidem、US 4382892 (1982、1983 both to Daiichi)、Formulations、Preparations: Table: Ofloxacin Preparations [Table#7976]、Table: Ofloxacin Preparations [Table#7977]、General Manufacturing Information: The methyl group at the C-3 position in the oxazine ring results in the formation of isoenantiomers、ofloxacin occurs as a racemic mixture of the two isomers. The S-(-)isomer is 8-128 times as active against susceptible gram-positive and gram-negative organisms as the R-(+)isomer and approximately twice as active as racemic ofloxacin. |
登记用途：Uses: MEDICATION、Use (kg、approx.) in Germany (2009): >1000、exact) in Germany (2009): 1202、Use (kg) in France (2004): 4137、Consumption (g per capita、approx.) in Germany (2009): 0.0122、exact) in Germany (2009): 0.0147、Consumption (g per capita) in France (2004): 0.0685、Excretion rate: 0.88、Calculated removal (%): 1.9、For the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms: <i>Corynebacterium<、i> species、<i>Staphylococus aureus<、i>、<i>Staphylococcus epidermidis<、<i>Streptococcus pneumoniae<、<i>Streptococcus<、i> (Groups C、F、G)、Viridans group streptococci、<i>Acinetobacter lwoffii<、<i>Haemophilus influenzae<、<i>Serratia marcescens<、i>. Levofloxacin is a synthetic chemotherapeutic agent used to treat severe and life threatening bacterial infection (L1009).、Use Classification: Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: Preparation: I. Hayakawa et al.、EP 47005、eidem、US 4382892 (1982、1983 both to Daiichi)、Formulations、Preparations: Table: Ofloxacin Preparations [Table#7976]、Table: Ofloxacin Preparations [Table#7977]、General Manufacturing Information: The methyl group at the C-3 position in the oxazine ring results in the formation of isoenantiomers、ofloxacin occurs as a racemic mixture of the two isomers. The S-(-)isomer is 8-128 times as active against susceptible gram-positive and gram-negative organisms as the R-(+)isomer and approximately twice as active as racemic ofloxacin.。
氧氟沙星 是一种化工化合物，登记 CAS 号为 82419-36-1，分子式 C18H20FN3O4（分子量 361.4）。
登记 CAS 号：82419-36-1
其分子式 C18H20FN3O4 由 18 个碳、20 个氢、1 个氟、3 个氮、4 个氧 组成。
别名/同义词：氧氟沙星 · ofloxacin
氧氟沙星 的 CAS 登记号为 82419-36-1。
分子式 C18H20FN3O4，分子量 361.4。
别名/同义词：氧氟沙星、ofloxacin。
登记用途：Uses: MEDICATION、Use (kg、approx.) in Germany (2009): >1000、exact) in Germany (2009): 1202、Use (kg) in France (2004): 4137、Consumption (g per capita、approx.) in Germany (2009): 0.0122、exact) in Germany (2009): 0.0147、Consumption (g per capita) in France (2004): 0.0685、Excretion rate: 0.88、Calculated removal (%): 1.9、For the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms: <i>Corynebacterium<、i> species、<i>Staphylococus aureus<、i>、<i>Staphylococcus epidermidis<、<i>Streptococcus pneumoniae<、<i>Streptococcus<、i> (Groups C、F、G)、Viridans group streptococci、<i>Acinetobacter lwoffii<、<i>Haemophilus influenzae<、<i>Serratia marcescens<、i>. Levofloxacin is a synthetic chemotherapeutic agent used to treat severe and life threatening bacterial infection (L1009).、Use Classification: Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: Preparation: I. Hayakawa et al.、EP 47005、eidem、US 4382892 (1982、1983 both to Daiichi)、Formulations、Preparations: Table: Ofloxacin Preparations [Table#7976]、Table: Ofloxacin Preparations [Table#7977]、General Manufacturing Information: The methyl group at the C-3 position in the oxazine ring results in the formation of isoenantiomers、ofloxacin occurs as a racemic mixture of the two isomers. The S-(-)isomer is 8-128 times as active against susceptible gram-positive and gram-negative organisms as the R-(+)isomer and approximately twice as active as racemic ofloxacin.。
氧氟沙星（CAS 82419-36-1）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 82419-36-1 |
|---|---|
| PubChem CID | 4583 |
| Molecular formula | C18H20FN3O4 |
| IUPAC name | 7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid |
| UNII (FDA) | A4P49JAZ9H |
| Molecular Weight | 361.4 |
|---|---|
| XLogP3 | -0.4 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 2 |
| Exact Mass | 361.14378429 |
| Monoisotopic Mass | 361.14378429 |
| Topological Polar Surface Area | 73.3 |
| Heavy Atom Count | 26 |
| Melting Point | 254 |
|---|---|
| Melting Point | 250-257 °C (decomposes) |
| Melting Point | 250 - 257 °C |
| Solubility | 28.3 |
| Solubility | 1.44e+00 g/L |
| LogP | -0.39 |
| LogP | log Kow = -0.39 |
| LogP | 2.1 |
| LogP | -0.05 |
| Ionization Efficiency | 3.3 |
ofloxacin; 82419-36-1; Floxin; Ofloxacine; Tarivid; Ocuflox; Ofloxacino; Visiren; Ofloxacinum; DL-8280; Ofloxacina; Exocin; Hoe-280; Floxin otic; Ofloxacin Otic; OFLX
| GHS notification summary | 23.1% (3 / 13) |
|---|
| GHS notification summary | 23.1% (3 / 13) |
|---|---|
| Reported hazard statements | H302 (85.2%), H312 (85.2%), H317 (85.2%), H332 (85.2%), H334 (85.2%), H341 (100%), H361 (14.8%), H315 (23.1%) |
H302 (85.2%): Harmful if swallowed [Warning Acute toxicity, oral]
H312 (85.2%): Harmful in contact with skin [Warning Acute toxicity, dermal]
ofloxacin · CAS 82419-36-1 · C18H20FN3O4. UNII A4P49JAZ9H. Melting Point: 254; Melting Point: 250-257 °C (decomposes); Melting Point: 250 - 257 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: ofloxacin