氢化可的松（CAS 50-23-7）：分子式 C21H30O5、分子量 362.5。
| CAS号 | 50-23-7 |
|---|---|
| 分子式 | C21H30O5 |
| 分子量 | 362.5 |
| 熔点 | 220 |
| LogP | 1.61 |
| 应用领域 | Uses: Medicine (antiinflammatory agent)、also used as the acetate and sodium succinate salts、THERAP CAT: Glucocorticoid、THERAP CAT (VET): Glucocorticoid、MEDICATION (VET)、MEDICATION、Use (kg、approx.) in Germany (2009): >1000、Use (kg) in USA (2002): 21000、Use (kg) in France (2004): 453、Consumption (g per capita、approx.) in Germany (2009): 0.0122、Consumption (g per capita) in the USA (2002): 0.0744、Consumption (g per capita) in France (2004): 0.0075、Excretion rate: 0.06、Calculated removal (%): 45.9、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Pharmaceuticals -> Hormones -> Steroid hormones、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Household Products: Information on 6 consumer products that contain Hydrocortisone in the following categories is provided:、• Personal Care、• Pet Care、Methods of Manufacturing: ISOLATION FROM ADRENAL GLANDS、Preparation by microbioal transformation: H.C. Murrary、D.H. Perterson、US 2602769 (1952 to Upjohn)、Formulations、Preparations: Ointment: 0.5% Cortizone-5、(Pfizer)、1% Cortizone-10、HydroSKIN、(Rugby)、2.5% Hytone、(Dermik). Pledgets (saturated with solution): 0.5% Massengill Medicated Soft Cloth Towelette (with parabens and propylene glycol)、(GlaxoSmithKline). Solution: 1% Cortaid FastStick Maximum Strength (with alcohol and methylparaben)、Cortaid Spray Maximum Strength (with alcohol and methylparaben)、Cortizone-10 Scalp Itch Formula Liquid (with alcohol SD 40-2 60% v、v、benzyl alcohol、and propylene glycol)、Penecort (with alcohol SD 40-2 57%、(Allergan)、Texacort (with SD alcohol 33% and propylene glycol)、(Sirius)、2.5% Texacort、(Sirius).、Lotion: 0.5% HydroSKIN、(Rugby). 1% Ala-Cort、(Del-Ray)、Aquanil HC (with benzyl alcohol)、(Person & Covey)、Cetacort (with parabens)、(Healthpoint)、Dermacort (with benzyl alcohol)、(Solvay) HydroSKIN、(Rugby) LactiCare-HC、(Stiefel) Nutracort (with parabens)、Sarnol HC、(Stiefel)、2% Ala-Scalpt、2.5% Hydrocortisone Lotion、(Glades)、Hydrocortisone Lotion、(Major)、Hytone (with propylene glycol)、(Dermik)、LactiCare-HC、Nutracort (with parabens)、ProctoCream-HC (with benzyl alcohol)、(Physicians Total Care).、Topical: Cream: 0.5% Cortizone-5 (with aloe and parabens)、Cortizone for Kids ( with aloe and parabens)、1% Ala-Cort、Cortaid Intensive Therapy (with parabens and propylene glycol)、Cortizone-10 (with aloe and parabens)、Cortizone-10 External Anal Itch Relief Creme ( with aloe and parabens)、Dermacort、(Solvay)、DermiCort (Republic)、Penecort (with benzyl alcohol and propylene glycol)、Preparation H Hydrocortisone (with parabens and propylene glycol)、(Wyeth)、2.5% Anusol-HC (with benzyl alcohol and propylene glycol)、(Dermik). Gel: 1% CortaGel Extra Strength、(Norstar).、Rectal: Cream: 1 Proctocort ( with benzyl alcohol and propylene glycol)、(Monarch)、Suspension: 100 mg、60 mL Cortenema ( with methylparaben)、Hydrocortisone Enema、(Copley).、For more Formulations、Preparations (Complete) data for HYDROCORTISONE (14 total)、please visit the HSDB record page.、General Manufacturing Information: Pregn-4-ene-3、20-dione、11、17、21-trihydroxy-、(11.beta.)-: ACTIVE、RELATIVE ANTIINFLAMMATORY POTENCY= 1、RELATIVE SODIUM RETAINING POTENCY= 1.、FROM TABLE |
登记用途：Uses: Medicine (antiinflammatory agent)、also used as the acetate and sodium succinate salts、THERAP CAT: Glucocorticoid、THERAP CAT (VET): Glucocorticoid、MEDICATION (VET)、MEDICATION、Use (kg、approx.) in Germany (2009): >1000、Use (kg) in USA (2002): 21000、Use (kg) in France (2004): 453、Consumption (g per capita、approx.) in Germany (2009): 0.0122、Consumption (g per capita) in the USA (2002): 0.0744、Consumption (g per capita) in France (2004): 0.0075、Excretion rate: 0.06、Calculated removal (%): 45.9、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Pharmaceuticals -> Hormones -> Steroid hormones、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Household Products: Information on 6 consumer products that contain Hydrocortisone in the following categories is provided:、• Personal Care、• Pet Care、Methods of Manufacturing: ISOLATION FROM ADRENAL GLANDS、Preparation by microbioal transformation: H.C. Murrary、D.H. Perterson、US 2602769 (1952 to Upjohn)、Formulations、Preparations: Ointment: 0.5% Cortizone-5、(Pfizer)、1% Cortizone-10、HydroSKIN、(Rugby)、2.5% Hytone、(Dermik). Pledgets (saturated with solution): 0.5% Massengill Medicated Soft Cloth Towelette (with parabens and propylene glycol)、(GlaxoSmithKline). Solution: 1% Cortaid FastStick Maximum Strength (with alcohol and methylparaben)、Cortaid Spray Maximum Strength (with alcohol and methylparaben)、Cortizone-10 Scalp Itch Formula Liquid (with alcohol SD 40-2 60% v、v、benzyl alcohol、and propylene glycol)、Penecort (with alcohol SD 40-2 57%、(Allergan)、Texacort (with SD alcohol 33% and propylene glycol)、(Sirius)、2.5% Texacort、(Sirius).、Lotion: 0.5% HydroSKIN、(Rugby). 1% Ala-Cort、(Del-Ray)、Aquanil HC (with benzyl alcohol)、(Person & Covey)、Cetacort (with parabens)、(Healthpoint)、Dermacort (with benzyl alcohol)、(Solvay) HydroSKIN、(Rugby) LactiCare-HC、(Stiefel) Nutracort (with parabens)、Sarnol HC、(Stiefel)、2% Ala-Scalpt、2.5% Hydrocortisone Lotion、(Glades)、Hydrocortisone Lotion、(Major)、Hytone (with propylene glycol)、(Dermik)、LactiCare-HC、Nutracort (with parabens)、ProctoCream-HC (with benzyl alcohol)、(Physicians Total Care).、Topical: Cream: 0.5% Cortizone-5 (with aloe and parabens)、Cortizone for Kids ( with aloe and parabens)、1% Ala-Cort、Cortaid Intensive Therapy (with parabens and propylene glycol)、Cortizone-10 (with aloe and parabens)、Cortizone-10 External Anal Itch Relief Creme ( with aloe and parabens)、Dermacort、(Solvay)、DermiCort (Republic)、Penecort (with benzyl alcohol and propylene glycol)、Preparation H Hydrocortisone (with parabens and propylene glycol)、(Wyeth)、2.5% Anusol-HC (with benzyl alcohol and propylene glycol)、(Dermik). Gel: 1% CortaGel Extra Strength、(Norstar).、Rectal: Cream: 1 Proctocort ( with benzyl alcohol and propylene glycol)、(Monarch)、Suspension: 100 mg、60 mL Cortenema ( with methylparaben)、Hydrocortisone Enema、(Copley).、For more Formulations、Preparations (Complete) data for HYDROCORTISONE (14 total)、please visit the HSDB record page.、General Manufacturing Information: Pregn-4-ene-3、20-dione、11、17、21-trihydroxy-、(11.beta.)-: ACTIVE、RELATIVE ANTIINFLAMMATORY POTENCY= 1、RELATIVE SODIUM RETAINING POTENCY= 1.、FROM TABLE。
氢化可的松 是一种化工化合物，登记 CAS 号为 50-23-7，分子式 C21H30O5（分子量 362.5）。
登记 CAS 号：50-23-7
其分子式 C21H30O5 由 21 个碳、30 个氢、5 个氧 组成。
别名/同义词：氢化可的松 · Hydrocortisone Base · Hydrocortisone
氢化可的松 的 CAS 登记号为 50-23-7。
分子式 C21H30O5，分子量 362.5。
别名/同义词：氢化可的松、Hydrocortisone Base、Hydrocortisone。
登记用途：Uses: Medicine (antiinflammatory agent)、also used as the acetate and sodium succinate salts、THERAP CAT: Glucocorticoid、THERAP CAT (VET): Glucocorticoid、MEDICATION (VET)、MEDICATION、Use (kg、approx.) in Germany (2009): >1000、Use (kg) in USA (2002): 21000、Use (kg) in France (2004): 453、Consumption (g per capita、approx.) in Germany (2009): 0.0122、Consumption (g per capita) in the USA (2002): 0.0744、Consumption (g per capita) in France (2004): 0.0075、Excretion rate: 0.06、Calculated removal (%): 45.9、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Pharmaceuticals -> Hormones -> Steroid hormones、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Household Products: Information on 6 consumer products that contain Hydrocortisone in the following categories is provided:、• Personal Care、• Pet Care、Methods of Manufacturing: ISOLATION FROM ADRENAL GLANDS、Preparation by microbioal transformation: H.C. Murrary、D.H. Perterson、US 2602769 (1952 to Upjohn)、Formulations、Preparations: Ointment: 0.5% Cortizone-5、(Pfizer)、1% Cortizone-10、HydroSKIN、(Rugby)、2.5% Hytone、(Dermik). Pledgets (saturated with solution): 0.5% Massengill Medicated Soft Cloth Towelette (with parabens and propylene glycol)、(GlaxoSmithKline). Solution: 1% Cortaid FastStick Maximum Strength (with alcohol and methylparaben)、Cortaid Spray Maximum Strength (with alcohol and methylparaben)、Cortizone-10 Scalp Itch Formula Liquid (with alcohol SD 40-2 60% v、v、benzyl alcohol、and propylene glycol)、Penecort (with alcohol SD 40-2 57%、(Allergan)、Texacort (with SD alcohol 33% and propylene glycol)、(Sirius)、2.5% Texacort、(Sirius).、Lotion: 0.5% HydroSKIN、(Rugby). 1% Ala-Cort、(Del-Ray)、Aquanil HC (with benzyl alcohol)、(Person & Covey)、Cetacort (with parabens)、(Healthpoint)、Dermacort (with benzyl alcohol)、(Solvay) HydroSKIN、(Rugby) LactiCare-HC、(Stiefel) Nutracort (with parabens)、Sarnol HC、(Stiefel)、2% Ala-Scalpt、2.5% Hydrocortisone Lotion、(Glades)、Hydrocortisone Lotion、(Major)、Hytone (with propylene glycol)、(Dermik)、LactiCare-HC、Nutracort (with parabens)、ProctoCream-HC (with benzyl alcohol)、(Physicians Total Care).、Topical: Cream: 0.5% Cortizone-5 (with aloe and parabens)、Cortizone for Kids ( with aloe and parabens)、1% Ala-Cort、Cortaid Intensive Therapy (with parabens and propylene glycol)、Cortizone-10 (with aloe and parabens)、Cortizone-10 External Anal Itch Relief Creme ( with aloe and parabens)、Dermacort、(Solvay)、DermiCort (Republic)、Penecort (with benzyl alcohol and propylene glycol)、Preparation H Hydrocortisone (with parabens and propylene glycol)、(Wyeth)、2.5% Anusol-HC (with benzyl alcohol and propylene glycol)、(Dermik). Gel: 1% CortaGel Extra Strength、(Norstar).、Rectal: Cream: 1 Proctocort ( with benzyl alcohol and propylene glycol)、(Monarch)、Suspension: 100 mg、60 mL Cortenema ( with methylparaben)、Hydrocortisone Enema、(Copley).、For more Formulations、Preparations (Complete) data for HYDROCORTISONE (14 total)、please visit the HSDB record page.、General Manufacturing Information: Pregn-4-ene-3、20-dione、11、17、21-trihydroxy-、(11.beta.)-: ACTIVE、RELATIVE ANTIINFLAMMATORY POTENCY= 1、RELATIVE SODIUM RETAINING POTENCY= 1.、FROM TABLE。
氢化可的松（CAS 50-23-7）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 50-23-7 |
|---|---|
| PubChem CID | 5754 |
| Molecular formula | C21H30O5 |
| IUPAC name | (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one |
| UNII (FDA) | WI4X0X7BPJ |
| Molecular Weight | 362.5 |
|---|---|
| XLogP3 | 1.6 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 2 |
| Exact Mass | 362.20932405 |
| Monoisotopic Mass | 362.20932405 |
| Topological Polar Surface Area | 94.8 |
| Heavy Atom Count | 26 |
| Melting Point | 220 |
|---|---|
| Melting Point | 220 °C |
| Solubility | 320 |
| Solubility | In water, 320 mg/L at 25 °C |
| Solubility | 0.32 mg/mL |
| LogP | 1.61 |
| LogP | log Kow = 1.61 |
| Collision Cross Section | 188.95 Ų [M+Cl]- |
| Collision Cross Section | 187.79 Ų [M+H]+ |
| Collision Cross Section | 191.98 Ų [M-H]- |
hydrocortisone; Cortisol; 50-23-7; Acticort; Cetacort; Hydrocortisyl; Cobadex; Hytone; Cortenema; Dermacort; Proctocort; Tarcortin; Cort-Dome; Efcorbin; Hycortol; Signef
| GHS notification summary | 1.1% (3 / 274) |
|---|
| GHS notification summary | 1.1% (3 / 274) |
|---|---|
| Reported hazard statements | H361 (86.5%), H373 (31.8%) |
This chemical does not meet GHS hazard criteria for 1.1% (3 of 274) of reports.
H361 (86.5%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
Hydrocortisone · CAS 50-23-7 · C21H30O5. UNII WI4X0X7BPJ. Melting Point: 220; Melting Point: 220 °C; Solubility: 320.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Hydrocortisone Base