去氧肾上腺素(CAS 1228015-39-1):分子式 C9H13NO2、分子量 167.20。
| CAS号 | 1228015-39-1 |
|---|---|
| 分子式 | C9H13NO2 |
| 分子量 | 167.20 |
| 熔点 | 140-145 °C |
| LogP | -0.31 |
| 应用领域 | Uses: Sympathomimetic vasoconstructor amine ... used for nasal congestion、Hydrochloride、... used to dilate the pupil both for ophthalmoscopy in the treatment of uveitis and for cataract surgery、MEDICATION、THERAP CAT: Mydriatic、decongestant、in treatment of fecal incontinence.、Use (kg、approx.) in Germany (2009): >100、Consumption (g per capita、approx.) in Germany (2009): 0.00122、Calculated removal (%): 92.1、Methods of Manufacturing: REACTION OF M-HYDROXYPHENACYL BROMIDE WITH METHYLAMINE FOLLOWED BY CATALYTIC HYDROGENATION、THEN DISSOLUTION IN ETHER、AND TREATMENT WITH HYDROGEN CHLORIDE、Preparation: H. Legerlotz、US 1932347 (1933 to Frederick Stearns)、M-HYDROXYPHENACYL BROMIDE IS CONDENSED WITH METHYLAMINE VIA DEHYDROBROMINATION & CARBONYL GROUP IS THEN REDUCED TO CARBINOL VIA CATALYTIC HYDROGENATION. PHENYLEPHRINE SO FORMED IS DISSOLVED IN SUITABLE SOLVENT SUCH AS ETHER & TREATED WITH HYDROGEN CHLORIDE.、PHENYLEPHRINE HYDROCHLORIDE、Formulations、Preparations: Oral: Strips、orally dissolving: 1.25 mg Triaminic Infant Thin Strips Decongestant、(Novartis) 2.5 mg Triaminic Thin Strips Cold、(Novartis). Tablets: 10 mg Sudafed PE、(Pfizer). Parenteral: Injection: 10 mg、mL Neo-Synephrine Hydrochloride (with sodium metabisulfite)、(Sanofi-Aventis)、Phenylephrine Hydrochloride Injection、(American Regent)、(Baxter). Topical: Cream: 0.25% with Glycerin 12%、(Petrolatum)、18%、and Shark Liver Oil 3% Preparation H (with cetyl alcohol、methylparaben、and stearyl alcohol)、(Wyeth). Gel: 0.25% with Witch Hazel 50% Preparation H (with methylparaben and propylparaben)、(Wyeth). Ointment: 0.25% with Mineral Oil 14%、Petrolatum 71.9%、and Shark Liver Oil 3% Preparation H (with methylparaben and propylparaben)、(Wyeth). Suppository: 0.25% with Cocoa Butter 85.5% and Shark Liver Oil 3% Preparation H (with methylparaben and propylparaben)、(Wyeth).、Nasal: Solution: 0.25% Neo-Synephrine Mild Formula Spray (with benzalkonium chloride)、(Bayer)、0.5% Neo-Synephrine Regular Strength (with benzalkonium chloride、drops and spray)、Vicks Sinex for Sinus Relief (with benzalkonium chloride、regular or metered pump mist spray)、(Procter & Gamble)、1% Neo-Synephrine Extra Strength (with benzalkonium chloride、(Bayer). Ophthalmic: Solution: 0.12% Ocu-Phrin、Ocumed Relief (with benzalkonium chloride)、(Allergan)、2.5% AK-Dilate (with benzalkonium chloride and sodium bisulfite)、(Akorn)、Mydfrin (with benzalkonium chloride and sodium bisulfite)、(Alcon) Neo-Synephrine Hydrochloride (with benzalkonium chloride)、Ocu-Phrin、(Ocumed)、10% AK-Dilate (with benzalkonium chloride and sodium bisulfite)、Neo-Synephrine Hydrochloride (with benzalkonium chloride、plain and viscous)、(Ocumed). Parenteral: Injection: 10 mg、(Baxter).、Phenylephrine hydrochloride、Ophthalmic: Solution: 0.12% Ocu-Phrin、Relief (with benzalkonium chloride、viscous)、(Alcon)、Neo-Synephrine Hydrochloride (with benzalkonium chloride)、Phenylephrine Hydrochloride Ophthalmic Solution、(Bausch & Lomb)、(Falcon)、(Ocumed).、U.S. Production: (1976) PROBABLY GREATER THAN 9.08X10+5 G、(1978) PROBABLY GREATER THAN 9.08X10+5 G、(1988) No data published for phenylephrine (bitartrate、hydrochloride、tannate)、U.S. Imports: (1976) 1.30X10+6 G (PRINCPL CUSTMS DISTS)、(1978) 4.43X10+6 G (PRINCPL CUSTMS DISTS) |
登记用途:Uses: Sympathomimetic vasoconstructor amine ... used for nasal congestion、Hydrochloride、... used to dilate the pupil both for ophthalmoscopy in the treatment of uveitis and for cataract surgery、MEDICATION、THERAP CAT: Mydriatic、decongestant、in treatment of fecal incontinence.、Use (kg、approx.) in Germany (2009): >100、Consumption (g per capita、approx.) in Germany (2009): 0.00122、Calculated removal (%): 92.1、Methods of Manufacturing: REACTION OF M-HYDROXYPHENACYL BROMIDE WITH METHYLAMINE FOLLOWED BY CATALYTIC HYDROGENATION、THEN DISSOLUTION IN ETHER、AND TREATMENT WITH HYDROGEN CHLORIDE、Preparation: H. Legerlotz、US 1932347 (1933 to Frederick Stearns)、M-HYDROXYPHENACYL BROMIDE IS CONDENSED WITH METHYLAMINE VIA DEHYDROBROMINATION & CARBONYL GROUP IS THEN REDUCED TO CARBINOL VIA CATALYTIC HYDROGENATION. PHENYLEPHRINE SO FORMED IS DISSOLVED IN SUITABLE SOLVENT SUCH AS ETHER & TREATED WITH HYDROGEN CHLORIDE.、PHENYLEPHRINE HYDROCHLORIDE、Formulations、Preparations: Oral: Strips、orally dissolving: 1.25 mg Triaminic Infant Thin Strips Decongestant、(Novartis) 2.5 mg Triaminic Thin Strips Cold、(Novartis). Tablets: 10 mg Sudafed PE、(Pfizer). Parenteral: Injection: 10 mg、mL Neo-Synephrine Hydrochloride (with sodium metabisulfite)、(Sanofi-Aventis)、Phenylephrine Hydrochloride Injection、(American Regent)、(Baxter). Topical: Cream: 0.25% with Glycerin 12%、(Petrolatum)、18%、and Shark Liver Oil 3% Preparation H (with cetyl alcohol、methylparaben、and stearyl alcohol)、(Wyeth). Gel: 0.25% with Witch Hazel 50% Preparation H (with methylparaben and propylparaben)、(Wyeth). Ointment: 0.25% with Mineral Oil 14%、Petrolatum 71.9%、and Shark Liver Oil 3% Preparation H (with methylparaben and propylparaben)、(Wyeth). Suppository: 0.25% with Cocoa Butter 85.5% and Shark Liver Oil 3% Preparation H (with methylparaben and propylparaben)、(Wyeth).、Nasal: Solution: 0.25% Neo-Synephrine Mild Formula Spray (with benzalkonium chloride)、(Bayer)、0.5% Neo-Synephrine Regular Strength (with benzalkonium chloride、drops and spray)、Vicks Sinex for Sinus Relief (with benzalkonium chloride、regular or metered pump mist spray)、(Procter & Gamble)、1% Neo-Synephrine Extra Strength (with benzalkonium chloride、(Bayer). Ophthalmic: Solution: 0.12% Ocu-Phrin、Ocumed Relief (with benzalkonium chloride)、(Allergan)、2.5% AK-Dilate (with benzalkonium chloride and sodium bisulfite)、(Akorn)、Mydfrin (with benzalkonium chloride and sodium bisulfite)、(Alcon) Neo-Synephrine Hydrochloride (with benzalkonium chloride)、Ocu-Phrin、(Ocumed)、10% AK-Dilate (with benzalkonium chloride and sodium bisulfite)、Neo-Synephrine Hydrochloride (with benzalkonium chloride、plain and viscous)、(Ocumed). Parenteral: Injection: 10 mg、(Baxter).、Phenylephrine hydrochloride、Ophthalmic: Solution: 0.12% Ocu-Phrin、Relief (with benzalkonium chloride、viscous)、(Alcon)、Neo-Synephrine Hydrochloride (with benzalkonium chloride)、Phenylephrine Hydrochloride Ophthalmic Solution、(Bausch & Lomb)、(Falcon)、(Ocumed).、U.S. Production: (1976) PROBABLY GREATER THAN 9.08X10+5 G、(1978) PROBABLY GREATER THAN 9.08X10+5 G、(1988) No data published for phenylephrine (bitartrate、hydrochloride、tannate)、U.S. Imports: (1976) 1.30X10+6 G (PRINCPL CUSTMS DISTS)、(1978) 4.43X10+6 G (PRINCPL CUSTMS DISTS)。
去氧肾上腺素 是一种化工化合物,登记 CAS 号为 1228015-39-1,分子式 C9H13NO2(分子量 167.20)。
登记 CAS 号:1228015-39-1
其分子式 C9H13NO2 由 9 个碳、13 个氢、1 个氮、2 个氧 组成。
别名/同义词:去氧肾上腺素 · Phenylephrine
去氧肾上腺素 的 CAS 登记号为 1228015-39-1。
分子式 C9H13NO2,分子量 167.20。
别名/同义词:去氧肾上腺素、Phenylephrine。
登记用途:Uses: Sympathomimetic vasoconstructor amine ... used for nasal congestion、Hydrochloride、... used to dilate the pupil both for ophthalmoscopy in the treatment of uveitis and for cataract surgery、MEDICATION、THERAP CAT: Mydriatic、decongestant、in treatment of fecal incontinence.、Use (kg、approx.) in Germany (2009): >100、Consumption (g per capita、approx.) in Germany (2009): 0.00122、Calculated removal (%): 92.1、Methods of Manufacturing: REACTION OF M-HYDROXYPHENACYL BROMIDE WITH METHYLAMINE FOLLOWED BY CATALYTIC HYDROGENATION、THEN DISSOLUTION IN ETHER、AND TREATMENT WITH HYDROGEN CHLORIDE、Preparation: H. Legerlotz、US 1932347 (1933 to Frederick Stearns)、M-HYDROXYPHENACYL BROMIDE IS CONDENSED WITH METHYLAMINE VIA DEHYDROBROMINATION & CARBONYL GROUP IS THEN REDUCED TO CARBINOL VIA CATALYTIC HYDROGENATION. PHENYLEPHRINE SO FORMED IS DISSOLVED IN SUITABLE SOLVENT SUCH AS ETHER & TREATED WITH HYDROGEN CHLORIDE.、PHENYLEPHRINE HYDROCHLORIDE、Formulations、Preparations: Oral: Strips、orally dissolving: 1.25 mg Triaminic Infant Thin Strips Decongestant、(Novartis) 2.5 mg Triaminic Thin Strips Cold、(Novartis). Tablets: 10 mg Sudafed PE、(Pfizer). Parenteral: Injection: 10 mg、mL Neo-Synephrine Hydrochloride (with sodium metabisulfite)、(Sanofi-Aventis)、Phenylephrine Hydrochloride Injection、(American Regent)、(Baxter). Topical: Cream: 0.25% with Glycerin 12%、(Petrolatum)、18%、and Shark Liver Oil 3% Preparation H (with cetyl alcohol、methylparaben、and stearyl alcohol)、(Wyeth). Gel: 0.25% with Witch Hazel 50% Preparation H (with methylparaben and propylparaben)、(Wyeth). Ointment: 0.25% with Mineral Oil 14%、Petrolatum 71.9%、and Shark Liver Oil 3% Preparation H (with methylparaben and propylparaben)、(Wyeth). Suppository: 0.25% with Cocoa Butter 85.5% and Shark Liver Oil 3% Preparation H (with methylparaben and propylparaben)、(Wyeth).、Nasal: Solution: 0.25% Neo-Synephrine Mild Formula Spray (with benzalkonium chloride)、(Bayer)、0.5% Neo-Synephrine Regular Strength (with benzalkonium chloride、drops and spray)、Vicks Sinex for Sinus Relief (with benzalkonium chloride、regular or metered pump mist spray)、(Procter & Gamble)、1% Neo-Synephrine Extra Strength (with benzalkonium chloride、(Bayer). Ophthalmic: Solution: 0.12% Ocu-Phrin、Ocumed Relief (with benzalkonium chloride)、(Allergan)、2.5% AK-Dilate (with benzalkonium chloride and sodium bisulfite)、(Akorn)、Mydfrin (with benzalkonium chloride and sodium bisulfite)、(Alcon) Neo-Synephrine Hydrochloride (with benzalkonium chloride)、Ocu-Phrin、(Ocumed)、10% AK-Dilate (with benzalkonium chloride and sodium bisulfite)、Neo-Synephrine Hydrochloride (with benzalkonium chloride、plain and viscous)、(Ocumed). Parenteral: Injection: 10 mg、(Baxter).、Phenylephrine hydrochloride、Ophthalmic: Solution: 0.12% Ocu-Phrin、Relief (with benzalkonium chloride、viscous)、(Alcon)、Neo-Synephrine Hydrochloride (with benzalkonium chloride)、Phenylephrine Hydrochloride Ophthalmic Solution、(Bausch & Lomb)、(Falcon)、(Ocumed).、U.S. Production: (1976) PROBABLY GREATER THAN 9.08X10+5 G、(1978) PROBABLY GREATER THAN 9.08X10+5 G、(1988) No data published for phenylephrine (bitartrate、hydrochloride、tannate)、U.S. Imports: (1976) 1.30X10+6 G (PRINCPL CUSTMS DISTS)、(1978) 4.43X10+6 G (PRINCPL CUSTMS DISTS)。
去氧肾上腺素(CAS 1228015-39-1)的独立参考数据,整理自公开化学数据库。
| CAS Registry Number | 1228015-39-1 |
|---|---|
| PubChem CID | 6041 |
| Molecular formula | C9H13NO2 |
| IUPAC name | 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol |
| UNII (FDA) | 1WS297W6MV |
| Molecular Weight | 167.20 |
|---|---|
| XLogP3 | -0.3 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 3 |
| Exact Mass | 167.094628657 |
| Monoisotopic Mass | 167.094628657 |
| Topological Polar Surface Area | 52.5 |
| Heavy Atom Count | 12 |
| Melting Point | 140-145 °C |
|---|---|
| Melting Point | 169-172 °C |
| LogP | -0.31 |
| Dissociation Constants | 8.97 |
| Dissociation Constants | pKa = 8.97 |
phenylephrine; 59-42-7; Metasynephrine; m-Oxedrine; Mezaton; m-Sympatol; Metasympatol; Mesatone; m-Sympathol; m-Synephrine; Metaoxedrine; Metaoxedrin; Visadron; Mesaton; Isophrin; Fenilefrina
| Reported hazard statements | H302 (100%) |
|---|
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Phenylephrine · CAS 1228015-39-1 · C9H13NO2. UNII 1WS297W6MV. Melting Point: 140-145 °C; Melting Point: 169-172 °C; LogP: -0.31.
数据来源:PubChem / Wikidata;与随货 COA 不一致时以 COA 为准。
English page: Phenylephrine