依折麦布

CAS 163222-33-1C24H21F2NO3MW 409.4

依折麦布（CAS 163222-33-1）：分子式 C24H21F2NO3、分子量 409.4。

产品概览

CAS号	163222-33-1
分子式	C24H21F2NO3
分子量	409.4
熔点	163°C
LogP	4.5
应用领域	Uses: THERAP CAT: Antilipemic、Medication、So far only one cholesterol absorption inhibitor has reached the market: Ezetimibe. Although the detailed mechanism of action is not yet quite clear、Ezetimibe、inhibits the intestinal absorption of cholesterol and as a consequence lowers total plasma cholesterol.、Use (kg、approx.) in Germany (2009): >1000、Consumption (g per capita、approx.) in Germany (2009): 0.0122、Excretion rate: 0.89、Calculated removal (%): 27.4、Methods of Manufacturing: Preparation: S.B. Rosenblum et al.、WO 9508532、eidem US 5767115 (1995、1998 both to Schering)、Formulations、Preparations: Oral: Tablets: 10 mg with Simvastatin 10 mg Vytorin (Merck、Schering-Plough)、10 mg with Simvastatin 20 mg Vytorin (Merck、10 mg with Simvastatin 40 mg Vytorin (Merck、10 mg with Simvastatin 80 mg Vytorin (Merck、Schering-Plough).、Ezetimibe combinations、Oral: Tablets: 10 mg Zetia (Merck

应用领域

登记用途：Uses: THERAP CAT: Antilipemic、Medication、So far only one cholesterol absorption inhibitor has reached the market: Ezetimibe. Although the detailed mechanism of action is not yet quite clear、Ezetimibe、inhibits the intestinal absorption of cholesterol and as a consequence lowers total plasma cholesterol.、Use (kg、approx.) in Germany (2009): >1000、Consumption (g per capita、approx.) in Germany (2009): 0.0122、Excretion rate: 0.89、Calculated removal (%): 27.4、Methods of Manufacturing: Preparation: S.B. Rosenblum et al.、WO 9508532、eidem US 5767115 (1995、1998 both to Schering)、Formulations、Preparations: Oral: Tablets: 10 mg with Simvastatin 10 mg Vytorin (Merck、Schering-Plough)、10 mg with Simvastatin 20 mg Vytorin (Merck、10 mg with Simvastatin 40 mg Vytorin (Merck、10 mg with Simvastatin 80 mg Vytorin (Merck、Schering-Plough).、Ezetimibe combinations、Oral: Tablets: 10 mg Zetia (Merck。

技术档案

这个产品是什么

依折麦布是一种化工化合物，登记 CAS 号为 163222-33-1，分子式 C24H21F2NO3（分子量 409.4）。

识别信息

登记 CAS 号：163222-33-1

其分子式 C24H21F2NO3 由 24 个碳、21 个氢、2 个氟、1 个氮、3 个氧组成。

别名/同义词：依折麦布 · Ezetimibe

常见问题

依折麦布的 CAS 号是多少？

依折麦布的 CAS 登记号为 163222-33-1。

依折麦布的分子式与分子量是多少？

分子式 C24H21F2NO3，分子量 409.4。

依折麦布还有哪些别名？

别名/同义词：依折麦布、Ezetimibe。

依折麦布的登记用途是什么？

PubChem 公开数据

依折麦布（CAS 163222-33-1）的独立参考数据，整理自公开化学数据库。

各数据库的登记标识

CAS Registry Number	163222-33-1
PubChem CID	150311
Molecular formula	C24H21F2NO3
IUPAC name	(3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one
UNII (FDA)	EOR26LQQ24

计算分子描述符

Molecular Weight	409.4
XLogP3	4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	409.14894986
Monoisotopic Mass	409.14894986
Topological Polar Surface Area	60.8
Heavy Atom Count	30

在册的理化数值

Melting Point	163°C
Melting Point	164-166 °C
Solubility	8.46e-03 g/L
LogP	4.5
LogP	3.64

在册的记载用途

同义词与商品名

Ezetimibe; 163222-33-1; Zetia; Ezetrol; Ezedoc; (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one; Sch 58235; SCH-58235; SCH58235; ezetimiba; EOR26LQQ24; ezetimibum; DTXSID1044223; 2-Azetidinone, 1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-, (3R,4S)-; MK0653; NSC-758923

GHS 危害分类

Reported hazard statements	H410 (85%)

H410 (85%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P273, P391, and P501 (click each P-code to see the statement)

公开数据库对它的描述

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline · CAS 163222-33-1 · C24H21F2NO3. UNII EOR26LQQ24. Melting Point: 163°C; Melting Point: 164-166 °C; Solubility: 8.46e-03 g/L.

物理形态与操作说明

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。