HC蓝2

Description

2,2'-(4-(2-hydroxyethylamino)-3-nitro-phenylimino) · CAS 33229-34-4 · C12H19N3O5. UNII 6C0EL1931V. Melting Point: 182 to 194 °F (NTP, 1992); Melting Point: 93-98 °C (98% pure); LogP: Log P= 1.7.

Identification

CAS Registry Number	33229-34-4
PubChem CID	36383
Molecular formula	C12H19N3O5
IUPAC name	2-[4-[bis(2-hydroxyethyl)amino]-2-nitroanilino]ethanol
UNII (FDA)	6C0EL1931V

Computed Descriptors

Molecular Weight	285.30
XLogP3	0.4
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	8
Exact Mass	285.13247072
Monoisotopic Mass	285.13247072
Topological Polar Surface Area	122
Heavy Atom Count	20
Formal Charge	0

Physical & Chemical Properties

Melting Point	182 to 194 °F (NTP, 1992)
Melting Point	93-98 °C (98% pure)
LogP	Log P= 1.7

Physical description & handling notes

• Hc blue 2 is a dark blue to dark brown microcrystalline powder. (NTP, 1992)
• Dark-blue (75% pure) or blackish-blue (98% pure) solid, with a copper cast; [HSDB]
• Dark-blue microcrystalline (75% pure) or blackish-blue amorphous powder (98% pure), with a copper cast.
• less than 1 mg/mL at 75 °F (NTP, 1992)
• Soluble in water, ethanol, methanol and acetone
• 171.1 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID6020193]

Regulatory Status

Regulatory & Food Contact	CIR / INCI: Cosmetic ingredients (HC Blue No. 2) -> CIR (Cosmetic Ingredient Review) CIR / INCI: Hair dyeing
GHS notification summary	0.9% (1 / 116)

GHS Hazard Classification

GHS notification summary	0.9% (1 / 116)
Reported hazard statements	H315 (50%), H317 (40.5%), H319 (50%), H335 (49.1%), H412 (18.1%)

Documented Uses

• Used as a dye in semi-permanent hair dye formulations; Not commercially produced in the US; [HSDB]
• Dressing Hair [Category: Other]
• HC Blue #2 is used exclusively as a dye in semi-permanent hair coloring products. The concentration of HC Blue #2 used in these preparations ranges from 1.6-2%.
• Information on 15 consumer products that contain HC Blue No 2 in the following categories is provided:
• HC Blue #2 that is greater than or equal to 95% pure is produced commercially by the reaction of 4-fluoro-3-nitrobenzenamine with ethylene oxide to form 2,2-(4-fluoro-3-nitrophenyl)imino)bis(ethanol); this intermediate is reacted with monoethanolamine to form HC Blue #2.
• The technical grade is produced by reaction of 2-nitro-p-phenylenediamine with ethylene oxide or 2-chloroethanol.

Synonyms

33229-34-4; HC Blue no. 2; HC Blue 2; DTXSID6020193; NCI-C54897; 6C0EL1931V; Ethanol, 2,2'-((4-((2-hydroxyethyl)amino)-3-nitrophenyl)imino)di-; DTXCID80193; N1,N4,N4-Tris(2-hydroxyethyl)-2-nitro-p-phenylenediamine; COVARINE BLUE W 6122; p-Phenylenediamine, 3-nitro-N(sup 1),N(sup 1),N(sup 4)-tris(2-hydroxyethyl)-; RefChem:145365; 251-410-3; 2,2'-[4-(2-Hydroxyethylamino)-3-nitrophenylimino]diethanol; 2,2'-((4-((2-Hydroxyethyl)amino)-3-nitrophenyl)azanediyl)diethanol; 2-[4-[bis(2-hydroxyethyl)amino]-2-nitroanilino]ethanol

Frequently Asked Questions

What are the CAS number and molecular formula of 2,2'-(4-(2-hydroxyethylamino)-3-nitro-phenylimino)?

CAS 33229-34-4; molecular formula C12H19N3O5; molecular weight — g/mol.

What other names is 2,2'-(4-(2-hydroxyethylamino)-3-nitro-phenylimino) known by?

33229-34-4, HC Blue no. 2, HC Blue 2, DTXSID6020193, NCI-C54897, 6C0EL1931V.

What is the regulatory status of 2,2'-(4-(2-hydroxyethylamino)-3-nitro-phenylimino)?

Documented regulatory listings: CIR / INCI: Cosmetic ingredients (HC Blue No. 2) -> CIR (Cosmetic Ingredient Review); CIR / INCI: Hair dyeing.

Is 2,2'-(4-(2-hydroxyethylamino)-3-nitro-phenylimino) classified as hazardous?

0.9% of GHS notifications report no hazard classification (1 of 116).

What are the key physical properties of 2,2'-(4-(2-hydroxyethylamino)-3-nitro-phenylimino)?

Melting Point: 182 to 194 °F (NTP, 1992); Melting Point: 93-98 °C (98% pure); LogP: Log P= 1.7.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.