2,3-二甲基-1-苯基-3-吡唑啉-5-酮

Description

2,3-dimethyl-1-phenyl-3-pyrazolin-5-one · CAS 60-80-0 · C11H12N2O. UNII T3CHA1B51H. Boiling Point: 319; Boiling Point: 319 °C; Melting Point: 114.

Identification

CAS Registry Number	60-80-0
PubChem CID	2206
Molecular formula	C11H12N2O
IUPAC name	1,5-dimethyl-2-phenylpyrazol-3-one
UNII (FDA)	T3CHA1B51H

Computed Descriptors

Molecular Weight	188.23
XLogP3	0.4
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	188.094963011
Monoisotopic Mass	188.094963011
Topological Polar Surface Area	23.6
Heavy Atom Count	14
Formal Charge	0

Physical & Chemical Properties

Boiling Point	319
Boiling Point	319 °C
Melting Point	114
Melting Point	114 °C
Melting Point	113 °C
Solubility	51900
Solubility	4.74e+01 g/L
LogP	0.38
LogP	0,23
LogP	0.42

Physical description & handling notes

• Solid
• COLOURLESS CRYSTALS OR WHITE POWDER.
• Solubility in water: very good
• 25.2 [ug/mL] (The mean of the results at pH 7.4)
• Relative density (water = 1): 1.19
• Positive

Regulatory Status

GHS notification summary	0.5% (1 / 184)

GHS Hazard Classification

GHS notification summary	0.5% (1 / 184)
Reported hazard statements	H302 (99.5%), H315 (54.9%), H317 (46.2%), H319 (54.9%), H335 (54.3%)

Documented Uses

• Use (kg) in Switzerland (2009): >25
• Use (kg; approx.) in Germany (2009): >2500
• Consumption (g per capita) in Switzerland (2009): 0.0032
• Consumption (g per capita; approx.) in Germany (2009): 0.031
• 3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-2-phenyl-: ACTIVE
• Antipyrine is an analgesic often used to test effects of other drugs on liver enzymes. In combination with benzocaine in otic solutions, antipyrine is indicated for the symptomatic relief of acute otitis media arising from various etiologies.

Synonyms

antipyrine; Phenazone; 60-80-0; Analgesine; Antipyrin; Fenazone; Antipyrinum; Phenazonum; 2,3-Dimethyl-1-phenyl-5-pyrazolone; Fenazona; 3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-2-phenyl-; 2,3-Dimethyl-1-phenyl-3-pyrazolin-5-one; 1,5-dimethyl-2-phenylpyrazol-3-one; 1,2-Dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one; 1,5-Dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one; DTXSID6021117

Frequently Asked Questions

What are the CAS number and molecular formula of 2,3-dimethyl-1-phenyl-3-pyrazolin-5-one?

CAS 60-80-0; molecular formula C11H12N2O; molecular weight — g/mol.

What other names is 2,3-dimethyl-1-phenyl-3-pyrazolin-5-one known by?

antipyrine, Phenazone, 60-80-0, Analgesine, Antipyrin, Fenazone.

Is 2,3-dimethyl-1-phenyl-3-pyrazolin-5-one classified as hazardous?

0.5% of GHS notifications report no hazard classification (1 of 184).

What are the key physical properties of 2,3-dimethyl-1-phenyl-3-pyrazolin-5-one?

Boiling Point: 319; Boiling Point: 319 °C; Melting Point: 114; Melting Point: 114 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.