Alprostadil

Description

Alprostadil · CAS 745-65-3 · C20H34O5. UNII F5TD010360. Melting Point: 115-116 °C; Melting Point: 115 - 116 °C; Solubility: 26.7.

Identification

CAS Registry Number	745-65-3
PubChem CID	5280723
Molecular formula	C20H34O5
IUPAC name	7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoic acid
UNII (FDA)	F5TD010360

Computed Descriptors

Molecular Weight	354.5
XLogP3	3.2
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	13
Exact Mass	354.24062418
Monoisotopic Mass	354.24062418
Topological Polar Surface Area	94.8
Heavy Atom Count	25
Formal Charge	0

Physical & Chemical Properties

Melting Point	115-116 °C
Melting Point	115 - 116 °C
Solubility	26.7
LogP	3.2
LogP	3.20
Dissociation Constants	4.87
Dissociation Constants	4.85 (at 25 °C)

Physical description & handling notes

• Solid
• 190.6 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Calculation: Single Field; Dataset: Oxylipins]
• 198.3 Ų [M+Na]+ [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]
• 181.94 Ų [M-H2O-H]- [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]

GHS Hazard Classification

Reported hazard statements	H301 (100%), H361 (56.8%)

Documented Uses

• Alprostadil is indicated for palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. It is also indicated for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology, and as an adjunct to other diagnostic tests in the diagnosis of erectile dysfunction.
• Medicines administered to the neonate [c]
• Parenteral - General injections - IV: 0.5 mg per mL in alcohol
• Other specified congenital anomaly of great arteries including arterial duct
• Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
• Drugs used to cause dilation of the blood vessels.

Synonyms

alprostadil; Prostaglandin E1; 745-65-3; PGE1; Caverject; Edex; Muse; Alprostadilum; Befar; Prostin VR Pediatric; Vitaros; Prink; PGE-1; Prostavasin; (11alpha,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid; Caverject Impulse

Frequently Asked Questions

What are the CAS number and molecular formula of Alprostadil?

CAS 745-65-3; molecular formula C20H34O5; molecular weight — g/mol.

What other names is Alprostadil known by?

alprostadil, Prostaglandin E1, 745-65-3, PGE1, Caverject, Edex.

Is Alprostadil classified as hazardous?

Hazard statements reported: H301, H361.

What are the key physical properties of Alprostadil?

Melting Point: 115-116 °C; Melting Point: 115 - 116 °C; Solubility: 26.7; LogP: 3.2.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.