利伐沙班

Description

Rivaroxaban · CAS 366789-02-8 · C19H18ClN3O5S. UNII 9NDF7JZ4M3.

Identification

CAS Registry Number	366789-02-8
PubChem CID	9875401
Molecular formula	C19H18ClN3O5S
IUPAC name	5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide
UNII (FDA)	9NDF7JZ4M3

Computed Descriptors

Molecular Weight	435.9
XLogP3	2.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	435.0655696
Monoisotopic Mass	435.0655696
Topological Polar Surface Area	116
Heavy Atom Count	29
Formal Charge	0

Physical description & handling notes

• White to yellowish powder
• Odorless
• Slightly soluble in organic solvents (e.g. acetone, polyethylene glycol 400) and is pratically insoluble in water and aqueous media
• Stable if stored as directed; avoid strong oxidizing agents
• Dangerous products of decomposition: thermal ecomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides.
• Table: Rivaroxaban Preparations [Table#8112]

Regulatory Status

GHS notification summary	1.2% (1 / 85)

GHS Hazard Classification

GHS notification summary	1.2% (1 / 85)
Reported hazard statements	H411 (89.4%)

Documented Uses

• Preparation: A. Straub et al., World Intellectual Property Organization patent 0147919; eidem, United States of America patent 7157456 (2001, 2007 both to Bayer)
• Rivaroxaban is a novel oral anticoagulant (NOAC) drug. It has several FDA-approved and off-label clinical uses.
• Rivaroxaban is an oral anticoagulant and direct factor Xa inhibitor which is used in the prevention of stroke and venous embolism in patients with chronic atrial fibrillation, as well as treatment and prevention of deep venous thromboses and pulmonary embolism. Rivaroxaban has been associated with a low rate of serum enzyme elevations during treatment and with rare instances of clinically apparent liver injury with jaundice.
• Breast Feeding; Lactation; Milk, Human; Anticoagulants; Antithrombins
• Medicines affecting coagulation
• (1) Venous thromboembolism; (2) Other specified atrial fibrillation

Synonyms

Rivaroxaban; 366789-02-8; Xarelto; BAY 59-7939; BAY59-7939; 9NDF7JZ4M3; BAY-59-7939; 5-Chloro-N-({(5s)-2-Oxo-3-[4-(3-Oxomorpholin-4-Yl)phenyl]-1,3-Oxazolidin-5-Yl}methyl)thiophene-2-Carboxamide; JNJ39039039; JNJ-39039039; CHEBI:68579; B01AF01; 2-Thiophenecarboxamide, 5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-; 5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide; 2-Thiophenecarboxamide, 5-chloro-N-(((5S)-2-oxo-3-(4-(3-oxo-4-morpholinyl)phenyl)-5-oxazolidinyl)methyl)-; 5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide

Frequently Asked Questions

What are the CAS number and molecular formula of Rivaroxaban?

CAS 366789-02-8; molecular formula C19H18ClN3O5S; molecular weight — g/mol.

What other names is Rivaroxaban known by?

Rivaroxaban, 366789-02-8, Xarelto, BAY 59-7939, BAY59-7939, 9NDF7JZ4M3.

Is Rivaroxaban classified as hazardous?

1.2% of GHS notifications report no hazard classification (1 of 85).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.