吡喹酮

Description

Praziquantel · CAS 55268-74-1 · C19H24N2O2. UNII 6490C9U457. Boiling Point: 1377; Melting Point: 136-138 °C; Melting Point: 136 °C.

Identification

CAS Registry Number	55268-74-1
PubChem CID	4891
Molecular formula	C19H24N2O2
IUPAC name	2-(cyclohexanecarbonyl)-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
UNII (FDA)	6490C9U457

Computed Descriptors

Molecular Weight	312.4
XLogP3	2.7
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	312.183778013
Monoisotopic Mass	312.183778013
Topological Polar Surface Area	40.6
Heavy Atom Count	23
Formal Charge	0

Physical & Chemical Properties

Boiling Point	1377
Melting Point	136-138 °C
Melting Point	136 °C
Solubility	400
Solubility	3.81e-01 g/L
LogP	2.5
LogP	2.43

Physical description & handling notes

• Solid
• >46.9 [ug/mL] (The mean of the results at pH 7.4)
• 178.5 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID9021182]
• 178.3 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID9021182]
• 185.4 Ų [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID9021182]
• 162.35 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Regulatory Status

GHS notification summary	1.8% (2 / 113)

GHS Hazard Classification

GHS notification summary	1.8% (2 / 113)
Reported hazard statements	H412 (91.2%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >10
• Consumption (g per capita; approx.) in Germany (2009): 0.000122
• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• Pharmaceuticals -> Animal Drugs -> Approved in Taiwan
• Information on 2 consumer products that contain Praziquantel in the following categories is provided:
• Praziquantel is indicated in patients aged 1 year and older for the treatment of the schistosomiasis due to all species of Schistosoma (for example, Schistosoma mekongi, Schistosoma japonicum, Schistosoma mansoni and Schistosoma hematobium) and clonorchiasis and opisthorchiasis due to the liver flukes, Clonorchis sinensis/Opisthorchis viverrini (approval of this indication was based on studies in which the two species were not differentiated).

Synonyms

praziquantel; 55268-74-1; Biltricide; Droncit; Embay 8440; Praziquantelum; Cysticide; DTXSID9021182; 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one; prazicuantel; EMBAY-8440; Praziquantel Tablets; NSC-757285; DTXCID501182; Praziquantel Injection; 4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-

Frequently Asked Questions

What are the CAS number and molecular formula of Praziquantel?

CAS 55268-74-1; molecular formula C19H24N2O2; molecular weight — g/mol.

What other names is Praziquantel known by?

praziquantel, 55268-74-1, Biltricide, Droncit, Embay 8440, Praziquantelum.

Is Praziquantel classified as hazardous?

1.8% of GHS notifications report no hazard classification (2 of 113).

What are the key physical properties of Praziquantel?

Boiling Point: 1377; Melting Point: 136-138 °C; Melting Point: 136 °C; Solubility: 400.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.