Oxaprozin

Description

Oxaprozin · CAS 21256-18-8 · C18H15NO3. UNII MHJ80W9LRB. Melting Point: 158-159 °C; Melting Point: 160.5 to 161.5 °C; Melting Point: 158 - 159 °C.

Identification

CAS Registry Number	21256-18-8
PubChem CID	4614
Molecular formula	C18H15NO3
IUPAC name	3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoic acid
UNII (FDA)	MHJ80W9LRB

Computed Descriptors

Molecular Weight	293.3
XLogP3	4.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	293.10519334
Monoisotopic Mass	293.10519334
Topological Polar Surface Area	63.3
Heavy Atom Count	22
Formal Charge	0

Physical & Chemical Properties

Melting Point	158-159 °C
Melting Point	160.5 to 161.5 °C
Melting Point	158 - 159 °C
Solubility	3.25e-02 g/L
LogP	4.19
LogP	log Kow = 4.19
LogP	3.7
LogP	2.82
Dissociation Constants	4.3
Dissociation Constants	pKa = 4.3

Physical description & handling notes

• Solid
• Crystals from methanol
• Insoluble
• Slightly soluble in alcohol. Insoluble in water
• When heated to decomposition it emits toxic fumes of /Nitrogen oxide/.
• 169.7 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (25%), H315 (25%), H319 (25%), H411 (25%), H412 (25%), H413 (25%)

Documented Uses

• Therapeutic Category: Anti-inflammatory
• Consumption (g per capita) in the USA (2002): 0.067
• Preparation: FR 2001036 (1969 Inst Farm Serano); ... K. Brown GB 1206403 and US 3578671 (1970, 1971 to Wyeth)
• Used to relieve the inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis and osteoarthritis.
• Oxaprozin is a long acting nonsteroidal antiinflammatory drug (NSAID) available by prescription only which is used for therapy of chronic arthritis. Oxaprozin has been linked to rare instances of idiosyncratic drug induced liver disease.
• Breast Feeding; Lactation; Milk, Human; Analgesic Agents; Anti-inflammatory Agents, Nonsteroidal

Synonyms

oxaprozin; 21256-18-8; Daypro; 3-(4,5-Diphenyloxazol-2-yl)propanoic acid; Alvo; Oxaprozine; Oxaprozinum; Deflam; Oxaprozina; 4,5-Diphenyl-2-oxazolepropanoic acid; 4,5-Diphenyl-2-oxazolepropionic acid; WY-21743; WY-21,743; 2-Oxazolepropanoic acid, 4,5-diphenyl-; Duraprox; DTXSID1045118

Frequently Asked Questions

What are the CAS number and molecular formula of Oxaprozin?

CAS 21256-18-8; molecular formula C18H15NO3; molecular weight — g/mol.

What other names is Oxaprozin known by?

oxaprozin, 21256-18-8, Daypro, 3-(4,5-Diphenyloxazol-2-yl)propanoic acid, Alvo, Oxaprozine.

Is Oxaprozin classified as hazardous?

Hazard statements reported: H302, H315, H319, H411, H412.

What are the key physical properties of Oxaprozin?

Melting Point: 158-159 °C; Melting Point: 160.5 to 161.5 °C; Melting Point: 158 - 159 °C; Solubility: 3.25e-02 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.