Finasteride

Description

Finasteride · CAS 98319-26-7 · C23H36N2O2. UNII 57GNO57U7G. Melting Point: 252-254 °C; Melting Point: 252 - 254 °C; Solubility: 1.98e-03 g/L.

Identification

CAS Registry Number	98319-26-7
PubChem CID	57363
Molecular formula	C23H36N2O2
IUPAC name	(1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-tert-butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide
UNII (FDA)	57GNO57U7G

Computed Descriptors

Molecular Weight	372.5
XLogP3	3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	372.277678395
Monoisotopic Mass	372.277678395
Topological Polar Surface Area	58.2
Heavy Atom Count	27
Formal Charge	0

Physical & Chemical Properties

Melting Point	252-254 °C
Melting Point	252 - 254 °C
Solubility	1.98e-03 g/L
LogP	3.03

Physical description & handling notes

• Solid
• White to off-white crystalline solid
• Slightly soluble
• Freely sol in chloroform, DMSO, ethanol, methanol, n-propanol; sparingly sol in propylene glycol, polyethylene glycol 400; very slightly sol in 0.1N hydrogen chloride, 0.1N sodium hydroxide, water.
• 52.8 [ug/mL] (The mean of the results at pH 7.4)
• 198.1 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID3020625]

GHS Hazard Classification

Reported hazard statements	H302 (99.1%), H360 (34.5%), H372 (47.3%), H410 (48.2%)

Documented Uses

• Medication: Treatment of benign prostatic hypertrophy
• Use (kg; approx.) in Germany (2009): >250
• Consumption (g per capita; approx.) in Germany (2009): 0.00305
• Consumption (g per capita) in the USA (2002): 0.00143
• For the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate to: Improve symptoms, reduce the risk of acute urinary retention, reduce the risk of the need for surgery including transurethral resection of the prostate. Also used for the stimulation of regrowth of hair in men with mild to moderate androgenetic alopecia (male pattern alopecia, hereditary alopecia, common male baldness).
• Finasteride is a 5-alpha reductase inhibitor used to treat symptoms of benign prostatic hypertrophy and male pattern baldness. Finasteride is associated with a low rate of transient serum aminotransferase elevations, but has yet to be linked to instances of clinically apparent, acute liver injury.

Synonyms

finasteride; 98319-26-7; Proscar; Propecia; Finastid; Prostide; Chibro-Proscar; MK-906; Finasterida; Finpecia; Finasteridum; MK 906; DTXSID3020625; N-tert-Butyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide; MK906; (5alpha,17beta)-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide

Frequently Asked Questions

What are the CAS number and molecular formula of Finasteride?

CAS 98319-26-7; molecular formula C23H36N2O2; molecular weight — g/mol.

What other names is Finasteride known by?

finasteride, 98319-26-7, Proscar, Propecia, Finastid, Prostide.

Is Finasteride classified as hazardous?

Hazard statements reported: H302, H360, H372, H410.

What are the key physical properties of Finasteride?

Melting Point: 252-254 °C; Melting Point: 252 - 254 °C; Solubility: 1.98e-03 g/L; LogP: 3.03.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.