小檗碱

Description

Berberine · CAS 2086-83-1 · C20H18NO4+. UNII 0I8Y3P32UF. Melting Point: 145; Melting Point: 145 °C.

Identification

CAS Registry Number	2086-83-1
PubChem CID	2353
Molecular formula	C20H18NO4+
IUPAC name	16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene
UNII (FDA)	0I8Y3P32UF

Computed Descriptors

Molecular Weight	336.4
XLogP3	3.6
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	336.12358306
Monoisotopic Mass	336.12358306
Topological Polar Surface Area	40.8
Heavy Atom Count	25
Formal Charge	1

Physical & Chemical Properties

Melting Point	145
Melting Point	145 °C

Physical description & handling notes

• Yellow solid; [Merck Index]
• Solid
• 173.48 Ų [M]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Regulatory Status

Regulatory & Food Contact	Berberine and Weight Loss: What You Need To Know

Documented Uses

• Occurs naturally in many plants and used in traditional medicine as an antiprotozoal, antimalarial, antibacterial, and antidiarrheal; [Merck Index]
• Berberine is a quaternary ammonia compound found in many botanical products, including goldenseal, barberry and Oregon grape, which is used for its purported antioxidant and antimicrobial properties for a host of conditions, including obesity, diabetes, hyperlipidemia, heart failure, H. pylori infection and colonic adenoma prevention. Berberine has not been linked to serum aminotransferase elevations during therapy nor to instances of clinically apparent liver injury.

Synonyms

berberine; 2086-83-1; Umbellatine; Berberin; Berbericine; Majarine; Thalsine; Umbellatin; Berberone; 0I8Y3P32UF; DTXSID9043857; CHEBI:16118; Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-; Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, 5,6-dihydro-9,10-dimethoxy-; 9,10-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium; 9,10-DIMETHOXY-5,6-DIHYDRO(1,3)DIOXOLO(4,5-G)ISOQUINO(3,2-A)ISOQUINOLIN-7-IUM

Frequently Asked Questions

What are the CAS number and molecular formula of Berberine?

CAS 2086-83-1; molecular formula C20H18NO4+; molecular weight — g/mol.

What other names is Berberine known by?

berberine, 2086-83-1, Umbellatine, Berberin, Berbericine, Majarine.

What is the regulatory status of Berberine?

Documented regulatory listings: Berberine and Weight Loss: What You Need To Know.

What are the key physical properties of Berberine?

Melting Point: 145; Melting Point: 145 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.