Repaglinide

Description

Repaglinide · CAS 135062-02-1 · C27H36N2O4. UNII 668Z8C33LU. Melting Point: 130-131 °C; Melting Point: 130 - 131 °C; Solubility: 2.94e-03 g/L.

Identification

CAS Registry Number	135062-02-1
PubChem CID	65981
Molecular formula	C27H36N2O4
IUPAC name	2-ethoxy-4-[2-[[(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butyl]amino]-2-oxoethyl]benzoic acid
UNII (FDA)	668Z8C33LU

Computed Descriptors

Molecular Weight	452.6
XLogP3	5.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	10
Exact Mass	452.26750763
Monoisotopic Mass	452.26750763
Topological Polar Surface Area	78.9
Heavy Atom Count	33
Formal Charge	0

Physical & Chemical Properties

Melting Point	130-131 °C
Melting Point	130 - 131 °C
Solubility	2.94e-03 g/L
LogP	5.9
LogP	3.2
Dissociation Constants	3.75

Physical description & handling notes

• Solid
• >67.9 [ug/mL] (The mean of the results at pH 7.4)

GHS Hazard Classification

Reported hazard statements	H361 (96.7%), H362 (98.3%), H412 (93.3%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
• Repaglinide is a drug used in the treatment of diabetes mellitus type 2. It belongs to a class of antihyperglycemic agents known as meglitinides, along with nateglinide. Meglitinides work to reduce blood glucose levels by stimulating endogenous insulin production. The present recommended starting dose is dependent on hemoglobin A1c levels, with those below 8% (64 mmol/mol) urged to start with 0.5 mg pre-prandially and those above 8% to start with 1 to 2 mg.
• Repaglinide is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been linked to rare instances of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Milk, Human; Hypoglycemic Agents

Synonyms

Repaglinide; 135062-02-1; Prandin; Repaglinida; AG-EE 623 ZW; GlucoNorm; AG-EE 388 ZW; Repaglinidum; AGEE-623ZW; enyglid; AG-EE-623ZW; 2-ethoxy-4-[2-[[(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butyl]amino]-2-oxoethyl]benzoic acid; DTXSID3023552; NSC-759893; AG-EE-623-ZW; A10BX02

Frequently Asked Questions

What are the CAS number and molecular formula of Repaglinide?

CAS 135062-02-1; molecular formula C27H36N2O4; molecular weight — g/mol.

What other names is Repaglinide known by?

Repaglinide, 135062-02-1, Prandin, Repaglinida, AG-EE 623 ZW, GlucoNorm.

Is Repaglinide classified as hazardous?

Hazard statements reported: H361, H362, H412.

What are the key physical properties of Repaglinide?

Melting Point: 130-131 °C; Melting Point: 130 - 131 °C; Solubility: 2.94e-03 g/L; LogP: 5.9.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.