氯霉素

氯霉素（CAS 56-75-7）：分子式 C11.H12.Cl2.N2.O5、分子量 323.13。

产品概览

应用领域

登记用途：Uses: Broad-spectrum antibiotic、[HSDB]、Anti-Bacterial Agents、Protein Synthesis Inhibitors、MEDICATION、MEDICATION (VET)、Use (kg、approx.) in Germany (2009): >50、exact) in Germany (2009): 68、Consumption (g per capita、approx.) in Germany (2009): 0.000611、exact) in Germany (2009): 0.00083、Calculated removal (%): 8.9、Used in treatment of cholera、as it destroys the vibrios and decreases the diarrhea. It is effective against tetracycline-resistant vibrios. It is also used in eye drops or ointment to treat bacterial conjunctivitis.、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Veterinary Drug -> ANTIMICROBIAL_AGENT -> JECFA Functional Classes、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: Broad spectrum antibiotic obtained from cultures of the soil bacterium Streptomyces venezuelae.、An antibiotic derived from Streptomyces venezuelae or by organic synthesis ... .、Chloramphenicol can be obtained from the filtrate of a Streptomyces venezuelae culture by extraction with ethyl acetate. If the charcoal extract is rich in chloramphenicol、the latter can be crystallized from the ethyl acetate by diluting with many volumes of kerosene.、Chloramphenicol can be synthesized by condensation of para-nitrobenzoyl chloride with ethyl malonate to give para-nitroacetophenone、followed by bromination in acetic acid to form para-nitro-alpha-bromoacetophenone、and reaction of this with hexamethylene tetramine、followed by hydrolysis to give para-nitro-alpha-aminoacetophenone、subsequent acetylation of the amine group and condensation with formaldehyde gives a hydroxymethyl group alpha to the amine group. Treatment with aluminium isopropylate reduces the keto group to a secondary alcohol、and、after deacetylation、condensation of the amine group with methyl dichloroacetate give chloramphenicol. Chemical syntheses of chloramphenicol usually include a resolution step to separate stereoisomers.、For more Methods of Manufacturing (Complete) data for Chloramphenicol (8 total)、please visit the HSDB record page.、Formulations、Preparations: Table: Chloramphenicol Sodium Succinate Preparations [Table#4355]、Chloromycetin Ophthalmic Ointment、1% (Chloramphenicol Ophthalmic Ointment、USP) is supplied、sterile、in ophthalmic ointment tubes of 3.5 grams.、Three common forms are used for systemic therapy、depending on the route of administration、a free base form of chloramphenicol、chloramphenicol palmitate and chloramphenicol succinate. Other formulations are also available for topical use.、Ak chlor liq 0.5%、Ak chlor oph ont 1%、Chloromycetin succinate injection 1 gm、Diochloram ointment 1%、Diochloram solution 0.5%、Pentamycetin liq 2.5 mg、mL、Pentamycetin ont 10 mg、gm、Pentamycetin ophthalmic solution 0.5% - liq、Pentamycetin、hc (combination product)、PMS-chloramphenicol ophthalmic soln 0.5%.、Chloramphenicol sodium succinate、For more Formulations、Preparations (Complete) data for Chloramphenicol (6 total)、U.S. Production: (1977) PROBABLY GREATER THAN 9.08X10+5 G、(1979) PROBABLY GREATER THAN 9.08X10+5 G、U.S. Imports: (1977) 8.15X10+6 G (PRINCPL CUSTMS DISTS)、(1979) 8.20X10+6 G (PRINCPL CUSTMS DISTS)、General Manufacturing Information: Acetamide、2、2-dichloro-N-[(1R、2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-: ACTIVE、The antibiotic is unique among natural compounds in that it contains nitrobenzene moiety and is a derivative of dichloroacetic acid.。

技术档案

这个产品是什么

氯霉素 是一种化工化合物，登记 CAS 号为 56-75-7，分子式 C11.H12.Cl2.N2.O5（分子量 323.13）。

识别信息

登记 CAS 号：56-75-7

其分子式 C11.H12.Cl2.N2.O5 由 11 个碳、12 个氢、2 个氯、2 个氮、5 个氧 组成。

别名/同义词：氯霉素 · Chloramphenicol

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PubChem 公开数据

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