Deflazacort

Description

Deflazacort · CAS 14484-47-0 · C25H31NO6. UNII KR5YZ6AE4B. Melting Point: >215 C; Solubility: 108; LogP: 2.4.

Identification

CAS Registry Number	14484-47-0
PubChem CID	189821
Molecular formula	C25H31NO6
IUPAC name	[2-[(1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-6,9,13-trimethyl-16-oxo-5-oxa-7-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-6,14,17-trien-8-yl]-2-oxoethyl] acetate
UNII (FDA)	KR5YZ6AE4B

Computed Descriptors

Molecular Weight	441.5
XLogP3	2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Exact Mass	441.21513771
Monoisotopic Mass	441.21513771
Topological Polar Surface Area	102
Heavy Atom Count	32
Formal Charge	0

Physical & Chemical Properties

Melting Point	>215 C
Solubility	108
LogP	2.4
Dissociation Constants	5.52

Physical description & handling notes

• 204.8 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID9020378]
• 206.7 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID9020378]
• 213.4 Ų [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID9020378]
• 205.2 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID9020378]

GHS Hazard Classification

Reported hazard statements	H360 (77.4%), H361 (16.1%), H373 (93.5%)

Documented Uses

• Deflazacort is indicated for the treatment of Duchenne Muscular Dystrophy (DMD) in patients 2 years of age and older.
• Breast Feeding; Lactation; Corticosteroids, Systemic; Glucocorticoids; Anti-Inflammatory Agents;
• Deflazacort (Class: Other Substances, Added Date: 08-2025)
• Avoid grapefruit products. Grapefruit inhibits CYP3A metabolism, which may increase the serum concentration of deflazacort.
• Avoid St. John's Wort. This herb induces CYP3A metabolism and may reduce serum levels of deflazacort.
• Take with or without food. The tablets may be crushed and mixed with applesauce and consumed immediately.

Synonyms

DEFLAZACORT; 14484-47-0; Emflaza; Deflazacortum; DTXSID9020378; MDL 458; DL-458IT; L-5458; MDL-458; KR5YZ6AE4B; MDL458; DTXCID10378; 5'H-Pregna-1,4-dieno[17,16-d]oxazole-3,20-dione, 21-(acetyloxy)-11-hydroxy-2'-methyl-, (11beta,16beta)-; 5'H-Pregna-1,4-dieno(17,16-d)oxazole-3,20-dione, 21-(acetyloxy)-11-hydroxy-2'-methyl-, (11beta,16beta)-; Deflazacort Oral; RefChem:56797

Frequently Asked Questions

What are the CAS number and molecular formula of Deflazacort?

CAS 14484-47-0; molecular formula C25H31NO6; molecular weight — g/mol.

What other names is Deflazacort known by?

DEFLAZACORT, 14484-47-0, Emflaza, Deflazacortum, DTXSID9020378, MDL 458.

Is Deflazacort classified as hazardous?

Hazard statements reported: H360, H361, H373.

What are the key physical properties of Deflazacort?

Melting Point: >215 C; Solubility: 108; LogP: 2.4; Dissociation Constants: 5.52.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.