Gliclazide

Description

Gliclazide · CAS 21187-98-4 · C15H21N3O3S. Melting Point: 180-182; Melting Point: 181 °C; Solubility: 1.90e-01 g/L.

Identification

CAS Registry Number	21187-98-4
PubChem CID	3475
Molecular formula	C15H21N3O3S
IUPAC name	1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea

Computed Descriptors

Molecular Weight	323.4
XLogP3	1.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	323.13036271
Monoisotopic Mass	323.13036271
Topological Polar Surface Area	86.9
Heavy Atom Count	22
Formal Charge	0

Physical & Chemical Properties

Melting Point	180-182
Melting Point	181 °C
Solubility	1.90e-01 g/L
LogP	2.6

Physical description & handling notes

• Solid
• 42.6 [ug/mL] (The mean of the results at pH 7.4)
• 164.21 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 176.8 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 182.91 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 181.89 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Regulatory Status

GHS notification summary	77.5% (55 / 71)

GHS Hazard Classification

GHS notification summary	77.5% (55 / 71)
Reported hazard statements	H302 (12.7%), H361 (14.1%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >10
• Consumption (g per capita; approx.) in Germany (2009): 0.000122
• For the treatment of NIDDM in conjunction with diet and exercise.
• Oral - Solid: 30 mg controlled-release; 60 mg controlled-release; 80 mg controlled-release
• Take with or without food. Consistent food intake reduces the risk of hypoglycemia.
• Substances which lower blood glucose levels.

Synonyms

gliclazide; 21187-98-4; Glimicron; Diamicron; Gliclazida; DTXSID9023095; S-852; 1-(3-Azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea; 1-(Hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea; DTXCID003095; CHEBI:31654; NSC-758673; J3.151H; SE-1702; Gliclazidum; S-1702

Frequently Asked Questions

What are the CAS number and molecular formula of Gliclazide?

CAS 21187-98-4; molecular formula C15H21N3O3S; molecular weight — g/mol.

What other names is Gliclazide known by?

gliclazide, 21187-98-4, Glimicron, Diamicron, Gliclazida, DTXSID9023095.

Is Gliclazide classified as hazardous?

77.5% of GHS notifications report no hazard classification (55 of 71).

What are the key physical properties of Gliclazide?

Melting Point: 180-182; Melting Point: 181 °C; Solubility: 1.90e-01 g/L; LogP: 2.6.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.