达克卡因

Description

dyclocaine · CAS 586-60-7 · C18H27NO2. UNII 078A24Q30O. Melting Point: 174-175; Solubility: 4.60e-02 g/L; LogP: 3.7.

Identification

CAS Registry Number	586-60-7
PubChem CID	3180
Molecular formula	C18H27NO2
IUPAC name	1-(4-butoxyphenyl)-3-piperidin-1-ylpropan-1-one
UNII (FDA)	078A24Q30O

Computed Descriptors

Molecular Weight	289.4
XLogP3	3.6
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	8
Exact Mass	289.204179104
Monoisotopic Mass	289.204179104
Topological Polar Surface Area	29.5
Heavy Atom Count	21
Formal Charge	0

Physical & Chemical Properties

Melting Point	174-175
Solubility	4.60e-02 g/L
LogP	3.7

Physical description & handling notes

• Solid
• Soluble (HCl salt)
• 178.11 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• Dyclonine is an oral anasthetic. If substantial quantities of local anesthetics are absorbed through the mucosa, actions on the central nervous system (CNS) may cause CNS stimulation and/or CNS depression. Actions on the cardiovascular system may cause depression of cardiac conduction and excitability and, with some of these agents, peripheral vasodilation.

Documented Uses

• Used to provide topical anesthesia of accessible mucous membranes prior to examination, endoscopy or instrumentation, or other procedures involving the esophagus, larynx, mouth, pharynx or throat, respiratory tract or trachea, urinary tract, or vagina. Also used to suppress the gag reflex and/or other laryngeal and esophageal reflexes to facilitate dental examination or procedures (including oral surgery), endoscopy, or intubation. Also used for relief of canker sores, cold sores or fever blister.
• Breast Feeding; Lactation; Anesthetics, Local
• Dyclonine (Class: Other Substances, Added Date: 10-1998)
• Take separate from meals. Using Dyclonine in the mouth or for relief of ulcers in the stomach may cause numbness of the mouth, which increases the risk of biting injury. Avoid ingesting food for 60 minutes after use, or until the numbness has subsided.
• N01BX - Other local anesthetics
• QN01BX - Other local anesthetics

Synonyms

dyclonine; Dyclocaine; 586-60-7; Diclonina; Dycloninum; 1-(4-butoxyphenyl)-3-(piperidin-1-yl)propan-1-one; 4'-Butoxy-3-piperidinopropiophenone; 3-Piperidino-4'-butoxypropiophenone; 1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone; 2-(1-piperidyl)ethyl p-butoxyphenyl ketone; 4-butoxy-beta-piperidinopropiophenone; 4-n-butoxy-beta-(1-piperidyl)propiophenone; 078A24Q30O; CHEBI:4724; DTXSID6047864; 1-propanone, 1-(4-butoxyphenyl)-3-(1-piperidinyl)

Frequently Asked Questions

What are the CAS number and molecular formula of dyclocaine?

CAS 586-60-7; molecular formula C18H27NO2; molecular weight — g/mol.

What other names is dyclocaine known by?

dyclonine, Dyclocaine, 586-60-7, Diclonina, Dycloninum, 1-(4-butoxyphenyl)-3-(piperidin-1-yl)propan-1-one.

What are the key physical properties of dyclocaine?

Melting Point: 174-175; Solubility: 4.60e-02 g/L; LogP: 3.7.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.