双氯芬酸依波拉明

Description

Diclofenac epolamine · CAS 119623-66-4 · C20H24Cl2N2O3. UNII X5F8EKL9ZG.

Identification

CAS Registry Number	119623-66-4
PubChem CID	114753
Molecular formula	C20H24Cl2N2O3
IUPAC name	2-[2-(2,6-dichloroanilino)phenyl]acetic acid;2-pyrrolidin-1-ylethanol
UNII (FDA)	X5F8EKL9ZG

Computed Descriptors

Molecular Weight	411.3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	410.1163980
Monoisotopic Mass	410.1163980
Topological Polar Surface Area	72.8
Heavy Atom Count	27
Formal Charge	0
Complexity	363

GHS Hazard Classification

Reported hazard statements	H301 (100%), H412 (50%)

Documented Uses

• For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
• Breast Feeding; Lactation; Milk, Human; Analgesic Agents; Anti-inflammatory Agents, Nonsteroidal
• Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
• Anti-Inflammatory Agents, Non-Steroidal [CS]; Decreased Prostaglandin Production [PE]; Nonsteroidal Anti-inflammatory Drug [EPC]; Cyclooxygenase Inhibitors [MoA]
• Hepatic. Route of Elimination: Diclofenac is eliminated through metabolism and subsequent urinary and biliary excretion of the glucuronide and the sulfate conjugates of the metabolites. Little or no free unchanged diclofenac is excreted in the urine. Approximately 65% of the dose is excreted in the urine and approximately 35% in the bile as conjugates of unchanged diclofenac plus metabolites. Half Life: 2 hours

Synonyms

diclofenac epolamine; 119623-66-4; Flector; DHEP; DIEP; Diclofenac hydroxyethylpyrrolidine; Diclofenac-epolamine; Diclofenac epolaminum; X5F8EKL9ZG; LICART; Diclofenac-N-(2-hydroxyethyl) pyrrolidine; DTXSID80152531; Diclofenac 1-(2-hydroxyethyl)pyrrolidinium salt; N-(2-Hydroxyethyl)pyrrolidinium (2-((2,6-dichlorophenyl)amino)phenyl)acetate; CHEBI:48296; RefChem:57630

Frequently Asked Questions

What are the CAS number and molecular formula of Diclofenac epolamine?

CAS 119623-66-4; molecular formula C20H24Cl2N2O3; molecular weight — g/mol.

What other names is Diclofenac epolamine known by?

diclofenac epolamine, 119623-66-4, Flector, DHEP, DIEP, Diclofenac hydroxyethylpyrrolidine.

Is Diclofenac epolamine classified as hazardous?

Hazard statements reported: H301, H412.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.