甲磺酸达拉非尼

甲磺酸达拉非尼（CAS 1195768-06-9）的独立参考数据，整理自公开化学数据库。

各数据库的登记标识

计算分子描述符

在册的理化数值

在册的记载用途

Dabrafenib is a selective inhibitor of mutated forms of BRAF kinase and is used alone or in combination with trametinib in the treatment of advanced malignant melanoma. Dabrafenib therapy is associated with transient elevations in serum aminotransferase during therapy, but has not been linked to instances of clinically apparent acute liver injury.Breast Feeding; Lactation; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors;

同义词与商品名

Dabrafenib; 1195765-45-7; GSK2118436A; GSK2118436; GSK-2118436; GSK-2118436A; QGP4HA4G1B; CHEBI:75045; DTXSID20152499; N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide; N-(3-(5-(2-AMINOPYRIMIDIN-4-YL)-2-TERT-BUTYL-1,3-THIAZOL-4-YL)-2-FLUOROPHENYL)-2,6-DIFLUOROBENZENESULFONAMIDE; N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide; dabrafenibum; RefChem:58040; DTXCID8074990; BRAF Inhibitor GSK2118436

GHS 危害分类

Reported hazard statements	H361 (22.2%), H373 (88.9%), H400 (100%), H410 (11.1%), H411 (88.9%)

H361 (22.2%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H361fd (77.8%): Suspected of damaging fertility; Suspected of damaging the unborn child [Warning Reproductive toxicity]

公开数据库对它的描述

dabrafenib mesylate · CAS 1195768-06-9 · C23H20F3N5O2S2. UNII QGP4HA4G1B. Boiling Point: 653.7; LogP: 2.9; Dissociation Constants: -1.5.

物理形态与操作说明

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。