丙吡胺游离碱

Description

disopyramide free base · CAS 3737-09-5 · C21H29N3O. UNII GFO928U8MQ. Melting Point: 94.5-95 °C; Melting Point: 94.5 - 95 °C; Solubility: 44.9.

Identification

CAS Registry Number	3737-09-5
PubChem CID	3114
Molecular formula	C21H29N3O
IUPAC name	4-[di(propan-2-yl)amino]-2-phenyl-2-pyridin-2-ylbutanamide
UNII (FDA)	GFO928U8MQ

Computed Descriptors

Molecular Weight	339.5
XLogP3	3.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	8
Exact Mass	339.231062557
Monoisotopic Mass	339.231062557
Topological Polar Surface Area	59.2
Heavy Atom Count	25
Formal Charge	0

Physical & Chemical Properties

Melting Point	94.5-95 °C
Melting Point	94.5 - 95 °C
Solubility	44.9
Solubility	4.93e-02 g/L
LogP	2.58
LogP	3.5
LogP	2.71
Dissociation Constants	10.32

Physical description & handling notes

• Solid
• 178.91 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 179.27 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 182.41 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 183.45 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (100%), H361 (90.5%)

Documented Uses

• For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, ventricular pre-excitation and cardiac dysrhythmias. It is a Class Ia antiarrhythmic drug.
• Disopyramide, a class 1A antiarrhythmic drug, received Food and Drug Administration approval on September 29, 1978, for established ventricular arrhythmias like sustained ventricular tachycardia that, in the physician's judgment, are life-threatening. As a Class Ia antiarrhythmic agent, disopyramide functions by blocking sodium channels in the cardiac cell membranes, which stabilizes cardiac electrical activity and can help restore a normal heart rhythm.
• Disopyramide is an oral antiarrhythmic agent that has been in wide use for several decades. Long term disopyramide therapy is associated with a low rate of serum enzyme elevations and is a rare cause of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Milk, Human; Antiarrhythmics
• Take with or without food. The absorption is unaffected by food.
• Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.

Synonyms

disopyramide; 3737-09-5; Dicorantil; Lispine; Disopiramida; Isorythm; Rythmodan P; Disopyramidum; Ritmilen; Dl-disopyramide; Searle-703; SC-7031; (rs)-disopyramide; DTXSID1045536; gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide; GFO928U8MQ

Frequently Asked Questions

What are the CAS number and molecular formula of disopyramide free base?

CAS 3737-09-5; molecular formula C21H29N3O; molecular weight — g/mol.

What other names is disopyramide free base known by?

disopyramide, 3737-09-5, Dicorantil, Lispine, Disopiramida, Isorythm.

Is disopyramide free base classified as hazardous?

Hazard statements reported: H302, H361.

What are the key physical properties of disopyramide free base?

Melting Point: 94.5-95 °C; Melting Point: 94.5 - 95 °C; Solubility: 44.9; Solubility: 4.93e-02 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.