Dolutegravir (CAS 1051375-16-6) — formula C20H19F2N3O5, molecular weight 419.4; category pharmaceutical intermediates and APIs.
Dolutegravir (CAS 1051375-16-6) is a chemical raw material in the pharmaceutical intermediates and APIs category. Its molecular formula C20H19F2N3O5 comprises 20 C, 19 H, 2 F, 3 N, 5 O atoms. Its molecular weight is about 419.4. Reported physicochemical data: melting point around 190-193ºC, LogP about 2.2. As a sourcing and distribution partner we help locate and compare this item across domestic and cross-border channels, arranging samples and batch orders with full COA and compliance files.
| CAS Number | 1051375-16-6 |
|---|---|
| Molecular Formula | C20H19F2N3O5 |
| Molecular Weight | 419.4 |
| Melting Point | 190-193ºC |
| LogP | 2.2 |
| Applications | MEDICATION, HIV Integrase Inhibitors, Methods of Manufacturing: Preparation: B. A. Johns et al, World Intellectual Property Organization patent 06116764 (2006 to Shionogi), eidem, United States of America patent 090318421 (2009) |
| Category | Pharmaceutical Intermediates & APIs |
Documented applications: MEDICATION, HIV Integrase Inhibitors, Methods of Manufacturing: Preparation: B. A. Johns et al, World Intellectual Property Organization patent 06116764 (2006 to Shionogi), eidem, United States of America patent 090318421 (2009).
Dolutegravir is a pharmaceutical intermediate or API compound with CAS registry number 1051375-16-6 and molecular formula C20H19F2N3O5 (molecular weight 419.4), belonging to the pharmaceutical intermediates and APIs segment of chemical raw materials.
CAS number: 1051375-16-6
Its molecular formula C20H19F2N3O5 comprises 20 C, 19 H, 2 F, 3 N, 5 O atoms.
Also known as: Dolutegravir · 多替拉韦
Category: pharmaceutical intermediates and APIs
The CAS registry number of Dolutegravir is 1051375-16-6.
Molecular formula C20H19F2N3O5, molecular weight 419.4.
It is also registered under: Dolutegravir, 多替拉韦.
Recorded applications: MEDICATION, HIV Integrase Inhibitors, Methods of Manufacturing: Preparation: B. A. Johns et al, World Intellectual Property Organization patent 06116764 (2006 to Shionogi), eidem, United States of America patent 090318421 (2009).
Category: Pharmaceutical Intermediates & APIs.
Packaging is agreed per order, from lab-scale packs to bulk, and confirmed with each order rather than fixed on the page. A Certificate of Analysis (COA) ships with every batch and MSDS is available; where the end use carries a regulatory limit (food contact, pharmaceutical or cosmetic), state the standard at enquiry and the grade is set against it.
Independent reference data for Dolutegravir (CAS 1051375-16-6), compiled from public chemistry databases.
| CAS Registry Number | 1051375-16-6 |
|---|---|
| PubChem CID | 54726191 |
| Molecular formula | C20H19F2N3O5 |
| IUPAC name | (3S,7R)-N-[(2,4-difluorophenyl)methyl]-11-hydroxy-7-methyl-9,12-dioxo-4-oxa-1,8-diazatricyclo[8.4.0.03,8]tetradeca-10,13-diene-13-carboxamide |
| UNII (FDA) | DKO1W9H7M1 |
| Molecular Weight | 419.4 |
|---|---|
| XLogP3 | 2.4 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 3 |
| Exact Mass | 419.12927704 |
| Monoisotopic Mass | 419.12927704 |
| Topological Polar Surface Area | 99.2 |
| Heavy Atom Count | 30 |
| Melting Point | 190-193ºC |
|---|---|
| LogP | 2.2 |
| Dissociation Constants | 8.2 |
Dolutegravir; 1051375-16-6; GSK1349572; S/GSK1349572; GSK 1349572; GSK-1349572; S-349572; DKO1W9H7M1; CHEBI:76010; DTXSID90909356; dolutegravirum; RefChem:56964; J05AX12; DTXCID701338419; Tivicay; Dolutegravir (GSK1349572)
| GHS notification summary | 33.3% (1 / 3) |
|---|
| GHS notification summary | 33.3% (1 / 3) |
|---|---|
| Reported hazard statements | H400 (66.7%), H410 (66.7%) |
This chemical does not meet GHS hazard criteria for 33.3% (1 of 3) of reports.
H400 (66.7%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
Dolutegravir · CAS 1051375-16-6 · C20H19F2N3O5. UNII DKO1W9H7M1. Melting Point: 190-193ºC; LogP: 2.2; Dissociation Constants: 8.2.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 多替拉韦