二氮嗪

Description

diazoxide · CAS 364-98-7 · C8H7ClN2O2S. UNII O5CB12L4FN. Melting Point: 330ºC; Melting Point: 330.5 °C; Solubility: 2850.

Identification

CAS Registry Number	364-98-7
PubChem CID	3019
Molecular formula	C8H7ClN2O2S
IUPAC name	7-chloro-3-methyl-4H-1λ6,2,4-benzothiadiazine 1,1-dioxide
UNII (FDA)	O5CB12L4FN

Computed Descriptors

Molecular Weight	230.67
XLogP3	1.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	0
Exact Mass	229.9916763
Monoisotopic Mass	229.9916763
Topological Polar Surface Area	66.9
Heavy Atom Count	14
Formal Charge	0

Physical & Chemical Properties

Melting Point	330ºC
Melting Point	330.5 °C
Solubility	2850
Solubility	5.52e-01 g/L
LogP	1.2
LogP	1.3
LogP	1.08
Dissociation Constants	8.74

Physical description & handling notes

• Solid
• 156.32 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 142.65 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 143.7 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (100%), H315 (47.2%), H319 (47.2%), H335 (46.1%), H360 (50.6%), H372 (39.3%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >10
• Consumption (g per capita; approx.) in Germany (2009): 0.000122
• Breast Feeding; Lactation; Milk, Human; Antihypertensive Agents; Vasodilator Agents; Blood Glucose; Glycemic Control
• (1) Oral - Liquid: 50 mg per mL; (2) Oral - Solid: 50 mg
• Persistent hyperinsulinaemic hypoglycaemia of infancy
• Diazoxide (Class: Other Substances, Added Date: 11-2014)

Synonyms

diazoxide; 364-98-7; Proglycem; Hyperstat; Hypertonalum; Mutabase; Diazoxido; Diazoxidum; 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; Diazossido; Sch 6783; SRG 95213; Sch-6783; SRG-95213; Eudemine injection; 2H-1,2,4-Benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide

Frequently Asked Questions

What are the CAS number and molecular formula of diazoxide?

CAS 364-98-7; molecular formula C8H7ClN2O2S; molecular weight — g/mol.

What other names is diazoxide known by?

diazoxide, 364-98-7, Proglycem, Hyperstat, Hypertonalum, Mutabase.

Is diazoxide classified as hazardous?

Hazard statements reported: H302, H315, H319, H335, H360.

What are the key physical properties of diazoxide?

Melting Point: 330ºC; Melting Point: 330.5 °C; Solubility: 2850; Solubility: 5.52e-01 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.