Difluprednate

Description

Difluprednate · CAS 23674-86-4 · C27H34F2O7. UNII S8A06QG2QE. Melting Point: 191-194.

Identification

CAS Registry Number	23674-86-4
PubChem CID	443936
Molecular formula	C27H34F2O7
IUPAC name	[(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] butanoate
UNII (FDA)	S8A06QG2QE

Computed Descriptors

Molecular Weight	508.5
XLogP3	3.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	8
Exact Mass	508.22725974
Monoisotopic Mass	508.22725974
Topological Polar Surface Area	107
Heavy Atom Count	36
Formal Charge	0

Physical & Chemical Properties

Melting Point	191-194

Physical description & handling notes

• Solid
• Difluprednate is a corticosteroid used as an anti-inflammatory steroidal drug used primarily in ocular surgery.

Regulatory Status

GHS notification summary	20% (1 / 5)

GHS Hazard Classification

GHS notification summary	20% (1 / 5)
Reported hazard statements	H302, H312, H332 (20%), H360 (20%), H361 (40%), H373 (40%)

Documented Uses

• For the treatment of inflammation and pain associated with ocular surgery.
• Breast Feeding; Lactation; Anti-Inflammatory Agents; Corticosteroids, Ophthalmic; Glucocorticoids;
• A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
• D07 - Corticosteroids, dermatological preparations
• D07AC - Corticosteroids, potent (group iii)
• QD07 - Corticosteroids, dermatological preparations

Synonyms

difluprednate; 23674-86-4; Durezol; DFBA; Difluprednato; Epitopic; Difluprednatum; DTXSID0046773; Difluoroprednisolone butyrate acetate; S8A06QG2QE; W 6309; W-6309; CM 9155; DTXCID8026773; 6-alpha,9-alpha-Difluoroprednisolone 17-butyrate 21-acetate; 21-(Acetyloxy)-6,9-difluoro-11-hydroxy-17-(1-oxobutoxy)pregna-1,4-diene-3,20-dione (6alpha,11beta)-

Frequently Asked Questions

What are the CAS number and molecular formula of Difluprednate?

CAS 23674-86-4; molecular formula C27H34F2O7; molecular weight — g/mol.

What other names is Difluprednate known by?

difluprednate, 23674-86-4, Durezol, DFBA, Difluprednato, Epitopic.

Is Difluprednate classified as hazardous?

20% of GHS notifications report no hazard classification (1 of 5).

What are the key physical properties of Difluprednate?

Melting Point: 191-194.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.