多沙唑嗪

Description

Doxazosin · CAS 74191-85-8 · C23H25N5O5. UNII NW1291F1W8. Boiling Point: 718; Melting Point: 275-277; Melting Point: 289 - 290 °C.

Identification

CAS Registry Number	74191-85-8
PubChem CID	3157
Molecular formula	C23H25N5O5
IUPAC name	[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone
UNII (FDA)	NW1291F1W8

Computed Descriptors

Molecular Weight	451.5
XLogP3	2.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	4
Exact Mass	451.18556891
Monoisotopic Mass	451.18556891
Topological Polar Surface Area	112
Heavy Atom Count	33
Formal Charge	0

Physical & Chemical Properties

Boiling Point	718
Melting Point	275-277
Melting Point	289 - 290 °C
Solubility	0.8%
Solubility	7.90e-01 g/L
LogP	2.1
LogP	3.38
Dissociation Constants	6.52

Physical description & handling notes

• Solid
• 202.9 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]
• 196.92 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 200.88 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 199.48 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (20%), H314 (80%), H373 (80%), H411 (80%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >250
• Consumption (g per capita; approx.) in Germany (2009): 0.00305
• Consumption (g per capita) in the USA (2002): 0.00149
• Doxazosin is indicated to treat the symptoms of benign prostatic hypertrophy, which may include urinary frequency, urgency, and nocturia, among other symptoms. In addition, doxazosin is indicated alone or in combination with various antihypertensive agents for the management of hypertension. Off-label uses of doxazosin include the treatment of pediatric hypertension and the treatment of ureteric calculi.
• Doxazosin is a nonselective alpha-1 adrenergic antagonist (alpha-blocker) used in the therapy of hypertension and benign prostatic hypertrophy. Doxazosin is associated with a low rate of transient serum aminotransferase elevations, but has not been linked to instances of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Milk, Human; Adrenergic alpha-Antagonists; Antihypertensive Agents

Synonyms

doxazosin; 74191-85-8; Doxazosine; Doxazosinum; Doxazosina; UK-33274; C02CA04; 1-(4-Amino-6,7-Dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazin; CHEBI:4708; UK 33274; 1-(4-Amino-6,7-dimethoxy-2-chinazolinyl)-4-(2,3-dihydro-1,4-benzodioxixin-2-ylcarbonyl)piperazin; DTXSID7022964; NW1291F1W8; Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl)-; 2-{4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazin-1-yl}-6,7-dimethoxyquinazolin-4-amine; (4-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-1-PIPERAZINYL)(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHANONE

Frequently Asked Questions

What are the CAS number and molecular formula of Doxazosin?

CAS 74191-85-8; molecular formula C23H25N5O5; molecular weight — g/mol.

What other names is Doxazosin known by?

doxazosin, 74191-85-8, Doxazosine, Doxazosinum, Doxazosina, UK-33274.

Is Doxazosin classified as hazardous?

Hazard statements reported: H302, H314, H373, H411.

What are the key physical properties of Doxazosin?

Boiling Point: 718; Melting Point: 275-277; Melting Point: 289 - 290 °C; Solubility: 0.8%.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.