西多福韦水合物（1:2）

Description

Cidofovir hydrate (1:2) · CAS 149394-66-1 · C8H14N3O6P. UNII 768M1V522C. Melting Point: 480; Melting Point: 260 °C (dec); Melting Point: 480 °C.

Identification

CAS Registry Number	149394-66-1
PubChem CID	60613
Molecular formula	C8H14N3O6P
IUPAC name	[(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethylphosphonic acid
UNII (FDA)	768M1V522C

Computed Descriptors

Molecular Weight	279.19
XLogP3	-3.6
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	279.06202217
Monoisotopic Mass	279.06202217
Topological Polar Surface Area	146
Heavy Atom Count	18
Formal Charge	0

Physical & Chemical Properties

Melting Point	480
Melting Point	260 °C (dec)
Melting Point	480 °C
Solubility	=170 mg/mL at pH 6-8
Solubility	1.15e+01 g/L
LogP	-3.9
LogP	-3.17

Physical description & handling notes

• Solid
• Fluffy white powder
• White crystalline powder
• Aqueous solubility >=170 mg/ml @ pH 6-8
• log Kow = -3.3 @ pH 7.1
• It is recommended that cidofovir admixtures be administered within 24 hours of preparation and that refrigeration or freezer storage not be used to extend this 24 hour limit.

Documented Uses

• Preparation: A. Holy et al., EP 253412; eidem, US 5142051 (1988, 1992 both to Ceskoslov. Akad, Ved; Rega Inst.) ... .
• For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS)
• Cidofovir is a nucleoside analogue and antiviral agent which is used in therapy of serious cytomegalovirus infections in immunocompromised patients. Cidofovir has been associated with mild-to-moderate serum aminotransferase elevations during intravenous therapy, but has not been convincingly linked to cases of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Milk, Human; Anti-Infective Agents; Antiviral Agents
• Cidofovir is used for the treatment of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS).
• Cidofovir has been used for the management of acyclovir-resistant herpes simplex virus (HSV-1 and HSV-2) infections in immunocompromised patients.

Synonyms

Cidofovir; 113852-37-2; Vistide; HPMPC; Cidofovir anhydrous; (S)-HPMPC; anhydrous cidofovir; GS-504; (S)-1-(3-Hydroxy-2-phosphonomethoxypropyl)cytosine; DTXSID3043734; GS 0504; GS504; GS-0504; 768M1V522C; NSC-742135; 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine

Frequently Asked Questions

What are the CAS number and molecular formula of Cidofovir hydrate (1:2)?

CAS 149394-66-1; molecular formula C8H14N3O6P; molecular weight — g/mol.

What other names is Cidofovir hydrate (1:2) known by?

Cidofovir, 113852-37-2, Vistide, HPMPC, Cidofovir anhydrous, (S)-HPMPC.

What are the key physical properties of Cidofovir hydrate (1:2)?

Melting Point: 480; Melting Point: 260 °C (dec); Melting Point: 480 °C; Solubility: =170 mg/mL at pH 6-8.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.