琥珀酸氯霉素

Description

Chloramphenicol Succinate · CAS 3544-94-3 · C15H16Cl2N2O8. UNII ZCX619U9A1.

Identification

CAS Registry Number	3544-94-3
PubChem CID	656580
Molecular formula	C15H16Cl2N2O8
IUPAC name	4-[(2R,3R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propoxy]-4-oxobutanoic acid
UNII (FDA)	ZCX619U9A1

Computed Descriptors

Molecular Weight	423.2
XLogP3	1.1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	10
Exact Mass	422.0283709
Monoisotopic Mass	422.0283709
Topological Polar Surface Area	159
Heavy Atom Count	27
Formal Charge	0

Physical description & handling notes

• Chloramphenicol succinate is a prodrug of chloramphenicol, which binds to bacterial ribosomes and prevents translation. It has a narrow therapeutic index and a moderate duration of action. Patients should be counselled regarding the risk of serious fatal blood dyscrasias.

GHS Hazard Classification

Reported hazard statements	H302 (66.7%), H315 (66.7%), H319 (66.7%), H332 (66.7%), H335 (66.7%), H371 (33.3%)

Documented Uses

• Chloramphenicol succinate is indicated to treat serious and susceptible bacterial infections where less dangerous drugs are ineffective or contraindicated.
• Substances that inhibit the growth or reproduction of BACTERIA.
• Chloramphenicol succinate has a high degree of interpatient variability, with a Tmax of 18 minutes to 3 hours. A 1g oral chloramphenicol succinate dose every 6-8 hours reaches a mean Cmax of 11.2µg/mL with a Tmax of 1 hour.
• 6-80% of chloramphenicol succinate is eliminated unchanged in the urine, though this is highly variable between patients. On average, 30% of chloramphenicol succinate is eliminated unchanged in the urine and 10% is eliminated as the active chloramphenicol in the urine.
• Chloramphenicol succinate has a volume of distribution of 0.2-3.1L/kg.
• Chloramphenicol succinate's total clearance is 530-540mL/min in patients with normal renal and hepatic function, and 354mL/min in patients with renal or hepatic dysfunction. Chloramphenicol succinate's renal clearance is 222-260mL/min in patients with normal renal and hepatic function, and 66mL/min in patients with renal or hepatic dysfunction.

Synonyms

CHLORAMPHENICOL SUCCINATE; 3544-94-3; chloramphenicol hemisuccinate; Levomycetin succinate; Chloramphenicol monosuccinate; Chloromycetin succinate; ZCX619U9A1; NSC-756676; DTXSID8048155; 4-[(2R,3R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propoxy]-4-oxo-butanoic acid; 4-((2R,3R)-2-((2,2-dichloroacetyl)amino)-3-hydroxy-3-(4-nitrophenyl)propoxy)-4-oxo-butanoic acid; RefChem:125272; DTXCID4028129; 222-590-0; Chronicin foam; 4-((2R,3R)-2-(2,2-dichloroacetamido)-3-hydroxy-3-(4-nitrophenyl)propoxy)-4-oxobutanoic acid

Frequently Asked Questions

What are the CAS number and molecular formula of Chloramphenicol Succinate?

CAS 3544-94-3; molecular formula C15H16Cl2N2O8; molecular weight — g/mol.

What other names is Chloramphenicol Succinate known by?

CHLORAMPHENICOL SUCCINATE, 3544-94-3, chloramphenicol hemisuccinate, Levomycetin succinate, Chloramphenicol monosuccinate, Chloromycetin succinate.

Is Chloramphenicol Succinate classified as hazardous?

Hazard statements reported: H302, H315, H319, H332, H335.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.