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Capmatinib

CAS 1029712-80-8C23H17FN6OMW 412.4

Capmatinib (CAS 1029712-80-8) — formula C23H17FN6O, molecular weight 412.4; category pharmaceutical intermediates and APIs.

Product Description

Capmatinib (CAS 1029712-80-8) is a chemical raw material in the pharmaceutical intermediates and APIs category. Its molecular formula C23H17FN6O comprises 23 C, 17 H, 1 F, 6 N, 1 O atoms. Its molecular weight is about 412.4. Reported physicochemical data: LogP about 2.9. As a sourcing and distribution partner we help locate and compare this item across domestic and cross-border channels, arranging samples and batch orders with full COA and compliance files.

Product Overview

CAS Number1029712-80-8
Molecular FormulaC23H17FN6O
Molecular Weight412.4
LogP2.9
CategoryPharmaceutical Intermediates & APIs

Technical Profile

What this product is

Capmatinib is a pharmaceutical intermediate or API compound with CAS registry number 1029712-80-8 and molecular formula C23H17FN6O (molecular weight 412.4), belonging to the pharmaceutical intermediates and APIs segment of chemical raw materials.

Identification

CAS number: 1029712-80-8

Its molecular formula C23H17FN6O comprises 23 C, 17 H, 1 F, 6 N, 1 O atoms.

Also known as: Capmatinib · 卡马替尼

Category: pharmaceutical intermediates and APIs

Frequently Asked Questions

What is the CAS number of Capmatinib?

The CAS registry number of Capmatinib is 1029712-80-8.

What is the molecular formula and molecular weight of Capmatinib?

Molecular formula C23H17FN6O, molecular weight 412.4.

What other names is Capmatinib known by?

It is also registered under: Capmatinib, 卡马替尼.

Which category does Capmatinib belong to?

Category: Pharmaceutical Intermediates & APIs.

Packaging & documentation

Packaging is agreed per order, from lab-scale packs to bulk, and confirmed with each order rather than fixed on the page. A Certificate of Analysis (COA) ships with every batch and MSDS is available; where the end use carries a regulatory limit (food contact, pharmaceutical or cosmetic), state the standard at enquiry and the grade is set against it.

PubChem Public Data

Independent reference data for Capmatinib (CAS 1029712-80-8), compiled from public chemistry databases.

Registry identifiers across databases

CAS Registry Number1029712-80-8
PubChem CID25145656
Molecular formulaC23H17FN6O
IUPAC name2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide
UNII (FDA)TY34L4F9OZ

Computed descriptors

Molecular Weight412.4
XLogP32.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass412.14478735
Monoisotopic Mass412.14478735
Topological Polar Surface Area85.1
Heavy Atom Count31

Documented uses on record

    In the US, capmatinib is indicated for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have a mutation that leads to mesenchymal-epithelial transition (MET) exon 14 skipping as detected by an FDA-approved test. Capmatinib is approved to treat adults with locally advanced unresectable or metastatic non-small cell lung cancer (NSCLC) with MET exon 14 skipping alterations in Canada.Capmatinib is an orally available, small molecule inhibitor of the mesenchymal-epithelial transition (MET) factor tyrosine kinase receptor that is used in selected patients with non-small cell lung cancer (NSCLC). Serum aminotransferase elevations are common during therapy with capmatinib, which rarely can lead to clinically apparent liver injury that can be severe and even fatal.

    Synonyms and trade names

    capmatinib; 1029712-80-8; INCB28060; INC-280; 2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide; INCB-28060; NVP-INC280-NX; INCB 28060; NVP-INC280; TY34L4F9OZ; 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide; INCB-28060 FREE BASE; DTXSID90145595; 2-fluoro-N-methyl-4-{7-[(quinolin-6-yl)methyl]imidazo[1,2-b][1,2,4]triazin-2-yl}benzamide; 2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide; capmatinibum

    GHS hazard classification

    Reported hazard statementsH301 (100%), H360 (25%), H373 (100%), H411 (100%)

    H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

    H360 (25%): May damage fertility or the unborn child [Danger Reproductive toxicity]

    What the public record says

    Capmatinib · CAS 1029712-80-8 · C23H17FN6O. UNII TY34L4F9OZ.

    Source: PubChem / Wikidata; the batch COA governs where values differ.

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Supplier: Jinan Shenghe Chemical Co., Ltd.

中文页面: 卡马替尼

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