卡博替尼 (S)-苹果酸盐

Description

cabozantinib (S)-malate · CAS 1140909-48-3 · C32H30FN3O10. UNII DR7ST46X58.

Identification

CAS Registry Number	1140909-48-3
PubChem CID	25102846
Molecular formula	C32H30FN3O10
IUPAC name	1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;(2S)-2-hydroxybutanedioic acid
UNII (FDA)	DR7ST46X58

Computed Descriptors

Molecular Weight	635.6
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	11
Exact Mass	635.19152232
Monoisotopic Mass	635.19152232
Topological Polar Surface Area	194
Heavy Atom Count	46
Formal Charge	0
Complexity	924

GHS Hazard Classification

Reported hazard statements	H302 (98.1%), H315 (94.2%), H319 (92.3%), H335 (92.3%), H360 (96.2%), H373 (98.1%)

Documented Uses

• Cabometyx (Cabozantinib-S-Malate)
• Cabozantinib-s-malate is approved to treat:
• • Differentiated thyroid cancer that has spread. It is used in adults and children aged 12 years and older who cannot receive radioactive iodine and whose cancer got worse after VEGFreceptor-targeted therapy. This use is approved for the Cabometyx brand of cabozantinib-s-malate.
• • Hepatocellular carcinoma (a type of liver cancer). It is used in patients who have already been treated with sorafenib. This use is approved for the Cabometyx brand of cabozantinib-s-malate.
• • Medullary thyroid cancer that has gotten worse and has spread to other parts of the body. This use is approved for the Cometriq brand of cabozantinib-s-malate.
• • Neuroendocrine tumor of the pancreas or another organ that is well-differentiated, has spread, and cannot be removed by surgery. It is used in adults and children aged 12 years and older whose cancer has been treated. This use is approved for the Cabometyx brand of cabozantinib-s-malate.

Synonyms

Cabozantinib S-malate; 1140909-48-3; Cabozantinib malate; cabozantinib (S)-malate; Cabometyx; XL184; DR7ST46X58; CHEBI:72319; DTXSID60915949; RefChem:1080604; DTXCID501510465; Cabozantinib malate (XL184); Cabozantinib (S-malate); Cabozantinib L-Malate Salt; MFCD20923480; Cabozantinib s-malate [USAN]

Frequently Asked Questions

What are the CAS number and molecular formula of cabozantinib (S)-malate?

CAS 1140909-48-3; molecular formula C32H30FN3O10; molecular weight — g/mol.

What other names is cabozantinib (S)-malate known by?

Cabozantinib S-malate, 1140909-48-3, Cabozantinib malate, cabozantinib (S)-malate, Cabometyx, XL184.

Is cabozantinib (S)-malate classified as hazardous?

Hazard statements reported: H302, H315, H319, H335, H360.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.