氯喹

Description

chloroquine · CAS 54-05-7 · C18H26ClN3. UNII 886U3H6UFF. Melting Point: 87-89.5; Melting Point: 87 °C; Melting Point: 289 °C.

Identification

CAS Registry Number	54-05-7
PubChem CID	2719
Molecular formula	C18H26ClN3
IUPAC name	4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine
UNII (FDA)	886U3H6UFF

Computed Descriptors

Molecular Weight	319.9
XLogP3	4.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	8
Exact Mass	319.1815255
Monoisotopic Mass	319.1815255
Topological Polar Surface Area	28.2
Heavy Atom Count	22
Formal Charge	0

Physical & Chemical Properties

Melting Point	87-89.5
Melting Point	87 °C
Melting Point	289 °C
Solubility	1.75e-02 g/L
LogP	4.63
LogP	log Kow = 4.63
LogP	4.3
LogP	4.61
Dissociation Constants	10.1
Dissociation Constants	pKa = 10.1

Physical description & handling notes

• Solid
• WHITE TO SLIGHTLY YELLOW, CRYSTALLINE POWDER
• Colorless crystals
• ODORLESS
• Bitter taste
• Bitter colorless crystals, dimorphic. Freely soluble in water, less sol in neutral or alkaline pH. Stable to heat in soln pH4 to 6.5. Practically in soluble in alcohol, benzene and chloroform /Diphosphate/

GHS Hazard Classification

Reported hazard statements	H302 (100%)

Documented Uses

• Antimalarial, antiamebic, antitheuratic, Lupus erthematus supressant
• Mesh Heading: Amebicides, antimalarials, antirheumatic Agents
• Use (kg; approx.) in Germany (2009): >750
• Consumption (g per capita; approx.) in Germany (2009): 0.00916
• For the suppressive treatment and for acute attacks of malaria due to P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum, Second-line agent in treatment of Rheumatoid Arthritis (A308).
• H. Andersag et al., US 2233970 (1941 to Winthrop)

Synonyms

chloroquine; 54-05-7; Aralen; Chloraquine; Chlorochin; Artrichin; Chloroquina; Reumachlor; Chloroquinium; Capquin; Chlorquin; Arthrochin; Bipiquin; Clorochina; Gontochin; Klorokin

Frequently Asked Questions

What are the CAS number and molecular formula of chloroquine?

CAS 54-05-7; molecular formula C18H26ClN3; molecular weight — g/mol.

What other names is chloroquine known by?

chloroquine, 54-05-7, Aralen, Chloraquine, Chlorochin, Artrichin.

Is chloroquine classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of chloroquine?

Melting Point: 87-89.5; Melting Point: 87 °C; Melting Point: 289 °C; Solubility: 1.75e-02 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.