头孢唑林

Description

Cefazolin · CAS 25953-19-9 · C14H14N8O4S3. UNII IHS69L0Y4T. Melting Point: 198-200 °C (decomposes); Solubility: 4.87e-01 g/L; LogP: -0.58.

Identification

CAS Registry Number	25953-19-9
PubChem CID	33255
Molecular formula	C14H14N8O4S3
IUPAC name	(6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
UNII (FDA)	IHS69L0Y4T

Computed Descriptors

Molecular Weight	454.5
XLogP3	-0.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	7
Exact Mass	454.03001448
Monoisotopic Mass	454.03001448
Topological Polar Surface Area	235
Heavy Atom Count	29
Formal Charge	0

Physical & Chemical Properties

Melting Point	198-200 °C (decomposes)
Solubility	4.87e-01 g/L
LogP	-0.58
LogP	log Kow = -0.58
LogP	-0.24

Physical description & handling notes

• Solid
• Needles from aqueous acetone
• Mol wt 476.50. White to yellowish-white, odorless crystalline powder with a bitter, salty taste. Crystallizes in alpha, beta, and gamma forms (Kariyone). Easily sol in water, slightly sol in methanol, ethanol. Practically insol in benzene, acetone, chloroform /Sodium salt/
• Easily sol in DMF, pyridine; sol in aq acetone, aq dioxane, aq ethanol; slightly sol in methanol. Practically insol in chloroform, benzene, ether.
• 186.2 Ų [M+H]+ [CCS Type: TW; Method: calibrated with Waters Major Mix]
• 192.7 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with Waters Major Mix]

GHS Hazard Classification

Reported hazard statements	H317 (100%), H334 (100%)

Documented Uses

• Vet: Antibacterial ... usually quite active against many gram-positive bacteria ... moderately active against gram-negative bacteria ... relatively susceptible to beta-lactamases ... not as effective against anaerobes as ... penicillins. /First-generation cephalosporins/
• Mesh Heading: anti-bacterial agents
• Use (kg; approx.) in Germany (2009): >10000
• Use (kg; exact) in Germany (2009): 10132
• Consumption (g per capita; approx.) in Germany (2009): 0.122
• Consumption (g per capita; exact) in Germany (2009): 0.124

Synonyms

cefazolin; 25953-19-9; Cephazolin; Cefazoline; Cephamezine; Cefamezin; Cephazoline; Cephazolidin; Cefazolina; Cefazolinum; Elzogram; DTXSID2022753; IHS69L0Y4T; J01DB04; CHEBI:474053; DTXCID302753

Frequently Asked Questions

What are the CAS number and molecular formula of Cefazolin?

CAS 25953-19-9; molecular formula C14H14N8O4S3; molecular weight — g/mol.

What other names is Cefazolin known by?

cefazolin, 25953-19-9, Cephazolin, Cefazoline, Cephamezine, Cefamezin.

Is Cefazolin classified as hazardous?

Hazard statements reported: H317, H334.

What are the key physical properties of Cefazolin?

Melting Point: 198-200 °C (decomposes); Solubility: 4.87e-01 g/L; LogP: -0.58; LogP: log Kow = -0.58.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.