卡莫司汀

Description

carmustine · CAS 154-93-8 · C5H9Cl2N3O2. UNII U68WG3173Y. Melting Point: 86 to 90 °F (NTP, 1992); Melting Point: 31; Melting Point: 31 °C.

Identification

CAS Registry Number	154-93-8
PubChem CID	2578
Molecular formula	C5H9Cl2N3O2
IUPAC name	1,3-bis(2-chloroethyl)-1-nitrosourea
UNII (FDA)	U68WG3173Y

Computed Descriptors

Molecular Weight	214.05
XLogP3	1.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	4
Exact Mass	213.0071819
Monoisotopic Mass	213.0071819
Topological Polar Surface Area	61.8
Heavy Atom Count	12
Formal Charge	0

Physical & Chemical Properties

Melting Point	86 to 90 °F (NTP, 1992)
Melting Point	31
Melting Point	31 °C
Solubility	4000
Solubility	In water, 4.0X10+3 mg/L at 25 °C
Solubility	1.53e+00 g/L
LogP	1.53
LogP	log kow = 1.53
LogP	1.5

Physical description & handling notes

• 1,3-bis(2-chloroethyl)-1-nitrosourea is an orange-yellow solid. (NTP, 1992)
• Solid
• Light yellow powder
• Light yellow powder that melts to an oily liquid
• less than 1 mg/mL at 64 °F (NTP, 1992)
• Very soluble in ethanol

GHS Hazard Classification

Reported hazard statements	H300 (100%), H350 (97.6%), H360 (97.6%), H341, H370, H372

Documented Uses

• Medication to treat cancer of the lymph system, cancerous brain tumors, and a certain type of bone marrow cancer
• THERAPEUTIC CATEGORY: Antineoplastic
• For the treatment of brain tumors, multiple myeloma, Hodgkin's disease and Non-Hodgkin's lymphomas.
• /Carmustine/ may be synthesized by nitrosation with sodium nitrite of the appropriate substituted uera - in this case 1,3-bis(2-chloroethyl)urea - in a cold, acid medium (e.g., formic acid).
• ... designed to deliver carmustine directly into the surgical cavity created when a brain tumor is resected /Gliadel wafer/
• Carmustine (BCNU) is a parenterally administered alkylating agent used alone and in combination with other antineoplastic agents in the treatment of several forms of cancer including leukemias, lymphomas, and breast, testicular, ovarian, gastric and pancreatic cancer. Carmustine therapy is associated with minor transient serum enzyme elevations and has been linked to cases of acute liver injury including cholestatic hepatitis and acute veno-occlusive disease.

Synonyms

carmustine; 154-93-8; 1,3-Bis(2-chloroethyl)-1-nitrosourea; BCNU; Carmustin; Nitrumon; Carmubris; BiCNU; Becenun; Bischloroethyl nitrosourea; Carmustina; Carmustinum; Bischlorethylnitrosurea; N,N'-BIS(2-CHLOROETHYL)-N-NITROSOUREA; Bischlorethylnitrosourea; Becenum

Frequently Asked Questions

What are the CAS number and molecular formula of carmustine?

CAS 154-93-8; molecular formula C5H9Cl2N3O2; molecular weight — g/mol.

What other names is carmustine known by?

carmustine, 154-93-8, 1,3-Bis(2-chloroethyl)-1-nitrosourea, BCNU, Carmustin, Nitrumon.

Is carmustine classified as hazardous?

Hazard statements reported: H300, H350, H360, H341, H370.

What are the key physical properties of carmustine?

Melting Point: 86 to 90 °F (NTP, 1992); Melting Point: 31; Melting Point: 31 °C; Solubility: 4000.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.