牛胰岛素（CAS 9004-10-8）：分子式 C256H381N65O77S6、分子量 5794。
| CAS号 | 9004-10-8 |
|---|---|
| 分子式 | C256H381N65O77S6 |
| 分子量 | 5794 |
| LogP | -12.8 |
| 应用领域 | Uses: Hormone of carbohydrate and lipid metabolism that is used to treat diabetes、[Merck Index]、MEDICATION、Indicated as an adjunct to diet and exercise to improve glycemic control in adults and children with type 1 and type 2 diabetes mellitus.、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Methods of Manufacturing: EXTRACTION OF THE PANCREAS OF SLAUGHTERED ANIMALS WITH ACIDIFIED DILUTE ALCOHOL、FOLLOWED BY PRECIPITATION WITH ABSOLUTE ALCOHOL、REDISSOLUTION、PRECIPITATION WITH ZINC CHLORIDE、& REDISSOLUTION IN WATER、SYNTHESIS OF HUMAN INSULIN: KATSOYAMIS ET AL、J AM CHEM SOC 88、164、166 (1966)、RUTTENBERG、SCIENCE 177、623 (1972) (FROM PORCINE INSULIN). ... APPROACHES TO COMMERCIAL SYNTHESIS: CHEM & ENG NEWS 52、19 (APRIL 29、1974).、BY USE OF PORCINE INSULIN AS STARTING MATERIAL、HUMAN INSULIN CAN NOW BE SYNTHESIZED WITH RELATIVE EASE.、Formulations、Preparations: ISOPHANE INSULIN SUSPENSION、USP (NPH INSULIN、ISOPHANE INSULIN)、GLOBIN ZINC INSULIN INJECTION、USP、PROTAMINE ZINC INSULIN SUSPENSION、INSULIN、INSULIN ZINC SUSPENSION PROMPT、INSULIN ZINC SUSPENSION (AMORPHOUS)、SEMILENTE ILETIN & INSULIN ZINC SUSPENDED EXTENDED、INSULIN ZINC SUSPENSION (CRYSTALLINE)、ULTRALENTE ILETIN、INSULIN ZINC SUSPENSION、Consumption Patterns: ESSENTIALLY 100% AS A MEDICINAL (1976)、U.S. Production: (1972) PROBABLY GREATER THAN 4.54X10+5 G、(1975) PROBABLY GREATER THAN 4.54X10+5 G、U.S. Imports: (1972) No Data、(1975) No Data、U.S. Exports: (1972) No Data、General Manufacturing Information: SINCE MOST SYNTHETIC METHODS GIVE LOW YIELDS、MAJOR SOURCE OF HORMONE FOR HUMAN CONSUMPTION REMAINS PANCREAS OF SLAUGHTERED ANIMALS.、INSULIN CAN EXIST AS MONOMER、DIMER、OR HEXAMER COMPOSED OF THREE SUCH DIMERS.、ON CONVERSION OF HUMAN PROINSULIN TO INSULIN、4 BASIC AMINO ACIDS (ARGININE 31、32、LYSINE 64 & ARGININE 65) & CONNECTOR OR C-PEPTIDE MADE UP OF RESIDUES 31-65 ARE REMOVED. RESULTANT INSULIN MOLECULE...A CHAIN WITH GLYCINE AS AMINO-TERMINAL RESIDUE & B CHAIN WITH PHENYLALANINE @ AMINO TERMINUS.、WITH MOL WT OF ABOUT 6000、IS MADE UP OF TWO CHAINS OF AMINO ACIDS JOINED TOGETHER BY DISULFIDE LINKAGES. ...THE TWO CHAINS、ARE、TERMED A FOR ACIDIC & B FOR BASIC...、For more General Manufacturing Information (Complete) data for INSULIN INJECTION (7 total)、please visit the HSDB record page. |
登记用途：Uses: Hormone of carbohydrate and lipid metabolism that is used to treat diabetes、[Merck Index]、MEDICATION、Indicated as an adjunct to diet and exercise to improve glycemic control in adults and children with type 1 and type 2 diabetes mellitus.、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Methods of Manufacturing: EXTRACTION OF THE PANCREAS OF SLAUGHTERED ANIMALS WITH ACIDIFIED DILUTE ALCOHOL、FOLLOWED BY PRECIPITATION WITH ABSOLUTE ALCOHOL、REDISSOLUTION、PRECIPITATION WITH ZINC CHLORIDE、& REDISSOLUTION IN WATER、SYNTHESIS OF HUMAN INSULIN: KATSOYAMIS ET AL、J AM CHEM SOC 88、164、166 (1966)、RUTTENBERG、SCIENCE 177、623 (1972) (FROM PORCINE INSULIN). ... APPROACHES TO COMMERCIAL SYNTHESIS: CHEM & ENG NEWS 52、19 (APRIL 29、1974).、BY USE OF PORCINE INSULIN AS STARTING MATERIAL、HUMAN INSULIN CAN NOW BE SYNTHESIZED WITH RELATIVE EASE.、Formulations、Preparations: ISOPHANE INSULIN SUSPENSION、USP (NPH INSULIN、ISOPHANE INSULIN)、GLOBIN ZINC INSULIN INJECTION、USP、PROTAMINE ZINC INSULIN SUSPENSION、INSULIN、INSULIN ZINC SUSPENSION PROMPT、INSULIN ZINC SUSPENSION (AMORPHOUS)、SEMILENTE ILETIN & INSULIN ZINC SUSPENDED EXTENDED、INSULIN ZINC SUSPENSION (CRYSTALLINE)、ULTRALENTE ILETIN、INSULIN ZINC SUSPENSION、Consumption Patterns: ESSENTIALLY 100% AS A MEDICINAL (1976)、U.S. Production: (1972) PROBABLY GREATER THAN 4.54X10+5 G、(1975) PROBABLY GREATER THAN 4.54X10+5 G、U.S. Imports: (1972) No Data、(1975) No Data、U.S. Exports: (1972) No Data、General Manufacturing Information: SINCE MOST SYNTHETIC METHODS GIVE LOW YIELDS、MAJOR SOURCE OF HORMONE FOR HUMAN CONSUMPTION REMAINS PANCREAS OF SLAUGHTERED ANIMALS.、INSULIN CAN EXIST AS MONOMER、DIMER、OR HEXAMER COMPOSED OF THREE SUCH DIMERS.、ON CONVERSION OF HUMAN PROINSULIN TO INSULIN、4 BASIC AMINO ACIDS (ARGININE 31、32、LYSINE 64 & ARGININE 65) & CONNECTOR OR C-PEPTIDE MADE UP OF RESIDUES 31-65 ARE REMOVED. RESULTANT INSULIN MOLECULE...A CHAIN WITH GLYCINE AS AMINO-TERMINAL RESIDUE & B CHAIN WITH PHENYLALANINE @ AMINO TERMINUS.、WITH MOL WT OF ABOUT 6000、IS MADE UP OF TWO CHAINS OF AMINO ACIDS JOINED TOGETHER BY DISULFIDE LINKAGES. ...THE TWO CHAINS、ARE、TERMED A FOR ACIDIC & B FOR BASIC...、For more General Manufacturing Information (Complete) data for INSULIN INJECTION (7 total)、please visit the HSDB record page.。
牛胰岛素 是一种化工化合物，登记 CAS 号为 9004-10-8，分子式 C256H381N65O77S6（分子量 5794）。
登记 CAS 号：9004-10-8
其分子式 C256H381N65O77S6 由 256 个碳、381 个氢、65 个氮、77 个氧、6 个硫 组成。
别名/同义词：牛胰岛素 · Bovine Insulin · Insulin
牛胰岛素 的 CAS 登记号为 9004-10-8。
分子式 C256H381N65O77S6，分子量 5794。
别名/同义词：牛胰岛素、Bovine Insulin、Insulin。
登记用途：Uses: Hormone of carbohydrate and lipid metabolism that is used to treat diabetes、[Merck Index]、MEDICATION、Indicated as an adjunct to diet and exercise to improve glycemic control in adults and children with type 1 and type 2 diabetes mellitus.、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Methods of Manufacturing: EXTRACTION OF THE PANCREAS OF SLAUGHTERED ANIMALS WITH ACIDIFIED DILUTE ALCOHOL、FOLLOWED BY PRECIPITATION WITH ABSOLUTE ALCOHOL、REDISSOLUTION、PRECIPITATION WITH ZINC CHLORIDE、& REDISSOLUTION IN WATER、SYNTHESIS OF HUMAN INSULIN: KATSOYAMIS ET AL、J AM CHEM SOC 88、164、166 (1966)、RUTTENBERG、SCIENCE 177、623 (1972) (FROM PORCINE INSULIN). ... APPROACHES TO COMMERCIAL SYNTHESIS: CHEM & ENG NEWS 52、19 (APRIL 29、1974).、BY USE OF PORCINE INSULIN AS STARTING MATERIAL、HUMAN INSULIN CAN NOW BE SYNTHESIZED WITH RELATIVE EASE.、Formulations、Preparations: ISOPHANE INSULIN SUSPENSION、USP (NPH INSULIN、ISOPHANE INSULIN)、GLOBIN ZINC INSULIN INJECTION、USP、PROTAMINE ZINC INSULIN SUSPENSION、INSULIN、INSULIN ZINC SUSPENSION PROMPT、INSULIN ZINC SUSPENSION (AMORPHOUS)、SEMILENTE ILETIN & INSULIN ZINC SUSPENDED EXTENDED、INSULIN ZINC SUSPENSION (CRYSTALLINE)、ULTRALENTE ILETIN、INSULIN ZINC SUSPENSION、Consumption Patterns: ESSENTIALLY 100% AS A MEDICINAL (1976)、U.S. Production: (1972) PROBABLY GREATER THAN 4.54X10+5 G、(1975) PROBABLY GREATER THAN 4.54X10+5 G、U.S. Imports: (1972) No Data、(1975) No Data、U.S. Exports: (1972) No Data、General Manufacturing Information: SINCE MOST SYNTHETIC METHODS GIVE LOW YIELDS、MAJOR SOURCE OF HORMONE FOR HUMAN CONSUMPTION REMAINS PANCREAS OF SLAUGHTERED ANIMALS.、INSULIN CAN EXIST AS MONOMER、DIMER、OR HEXAMER COMPOSED OF THREE SUCH DIMERS.、ON CONVERSION OF HUMAN PROINSULIN TO INSULIN、4 BASIC AMINO ACIDS (ARGININE 31、32、LYSINE 64 & ARGININE 65) & CONNECTOR OR C-PEPTIDE MADE UP OF RESIDUES 31-65 ARE REMOVED. RESULTANT INSULIN MOLECULE...A CHAIN WITH GLYCINE AS AMINO-TERMINAL RESIDUE & B CHAIN WITH PHENYLALANINE @ AMINO TERMINUS.、WITH MOL WT OF ABOUT 6000、IS MADE UP OF TWO CHAINS OF AMINO ACIDS JOINED TOGETHER BY DISULFIDE LINKAGES. ...THE TWO CHAINS、ARE、TERMED A FOR ACIDIC & B FOR BASIC...、For more General Manufacturing Information (Complete) data for INSULIN INJECTION (7 total)、please visit the HSDB record page.。
牛胰岛素（CAS 9004-10-8）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 9004-10-8 |
|---|---|
| PubChem CID | 70678557 |
| Molecular formula | C256H381N65O77S6 |
| Molecular Weight | 5794 |
|---|---|
| XLogP3 | -12.8 |
| Hydrogen Bond Donor Count | 78 |
| Hydrogen Bond Acceptor Count | 89 |
| Rotatable Bond Count | 178 |
| Exact Mass | 5791.6287098 |
| Monoisotopic Mass | 5789.6220002 |
| Topological Polar Surface Area | 2450 |
| Heavy Atom Count | 404 |
| pH | 2.5-3.5 |
|---|
9004-10-8; Endopancrine; Decurvon; Dermulin; Insular; Insulyl; Iszilin; Musulin; Iletin; Intesulin B; Insulina dalanatada; Insulinum dalanatum; AERx; INSULIN INJECTION; Insulina iniettabile neutra; Insulini injectio neutralis
| GHS notification summary | 99.1% (116 / 117) |
|---|
| GHS notification summary | 99.1% (116 / 117) |
|---|
This chemical does not meet GHS hazard criteria for 99.1% (116 of 117) of all reports.
Reported as not meeting GHS hazard criteria by 116 of 117 companies (only 0.9% companies provided GHS information). For more detailed information, please visit ECHA C&L website.
Insulin · CAS 9004-10-8 · C256H381N65O77S6. pH: 2.5-3.5.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Bovine Insulin