阿瓦普替尼

Description

Avapritinib · CAS 1703793-34-3 · C26H27FN10. UNII 513P80B4YJ.

Identification

CAS Registry Number	1703793-34-3
PubChem CID	118023034
Molecular formula	C26H27FN10
IUPAC name	(1S)-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine
UNII (FDA)	513P80B4YJ

Computed Descriptors

Molecular Weight	498.6
XLogP3	1.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	5
Exact Mass	498.24041907
Monoisotopic Mass	498.24041907
Topological Polar Surface Area	106
Heavy Atom Count	37
Formal Charge	0

Physical description & handling notes

• Avapritinib is a selective kinase inhibitor that negatively modulates the action of cell transporters to resensitize them to other chemotherapies. It has a long duration of action as it is given once daily. Patients should be counselled regarding the risk of intracranial hemorrhage, CNS effects, and embryo-fetal toxicity.

Documented Uses

• Avapritinib is a tyrosine kinase receptor inhibitor that targets mutant forms of several genes (KIT, PDGFRA) involved in gastrointestinal stromal tumors which are often found in refractory cases. Serum aminotransferase elevations arise in a small proportion of patients treated with the highest doses of avapritinib, but episodes of clinically apparent liver injury have not been reported with its use.
• Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; Tyrosine Kinase Inhibitors
• Avapritinib is approved to treat adults with:
• • Gastrointestinal stromal tumor (GIST) that cannot be removed by surgery or has metastasized (spread to other parts of the body) and has certain mutations in the PDGFRA gene.
• • Systemic mastocytosis that is advanced, including the following types:
• • Aggressive systemic mastocytosis.

Synonyms

Avapritinib; 1703793-34-3; BLU-285; Ayvakit; 513P80B4YJ; C-366; 70C366; DTXSID301027935; X720776; X-720776; avapritinibum; RefChem:56916; DTXCID501513502; CS3007; PDGFR alpha/KIT Mutant-specific Inhibitor BLU-285; MFCD31544325

Frequently Asked Questions

What are the CAS number and molecular formula of Avapritinib?

CAS 1703793-34-3; molecular formula C26H27FN10; molecular weight — g/mol.

What other names is Avapritinib known by?

Avapritinib, 1703793-34-3, BLU-285, Ayvakit, 513P80B4YJ, C-366.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.