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Avapritinib

CAS 1703793-34-3C26H27FN10MW 498.6

Avapritinib (CAS 1703793-34-3) — formula C26H27FN10, molecular weight 498.6; category pharmaceutical intermediates and APIs.

Product Description

Avapritinib (CAS 1703793-34-3) is a chemical raw material in the pharmaceutical intermediates and APIs category. Its molecular formula C26H27FN10 comprises 26 C, 27 H, 1 F, 10 N atoms. Its molecular weight is about 498.6. Reported physicochemical data: LogP about 1.9. As a sourcing and distribution partner we help locate and compare this item across domestic and cross-border channels, arranging samples and batch orders with full COA and compliance files.

Product Overview

CAS Number1703793-34-3
Molecular FormulaC26H27FN10
Molecular Weight498.6
LogP1.9
CategoryPharmaceutical Intermediates & APIs

Technical Profile

What this product is

Avapritinib is a pharmaceutical intermediate or API compound with CAS registry number 1703793-34-3 and molecular formula C26H27FN10 (molecular weight 498.6), belonging to the pharmaceutical intermediates and APIs segment of chemical raw materials.

Identification

CAS number: 1703793-34-3

Its molecular formula C26H27FN10 comprises 26 C, 27 H, 1 F, 10 N atoms.

Also known as: Avapritinib · 阿瓦普替尼

Category: pharmaceutical intermediates and APIs

Frequently Asked Questions

What is the CAS number of Avapritinib?

The CAS registry number of Avapritinib is 1703793-34-3.

What is the molecular formula and molecular weight of Avapritinib?

Molecular formula C26H27FN10, molecular weight 498.6.

What other names is Avapritinib known by?

It is also registered under: Avapritinib, 阿瓦普替尼.

Which category does Avapritinib belong to?

Category: Pharmaceutical Intermediates & APIs.

Packaging & documentation

Packaging is agreed per order, from lab-scale packs to bulk, and confirmed with each order rather than fixed on the page. A Certificate of Analysis (COA) ships with every batch and MSDS is available; where the end use carries a regulatory limit (food contact, pharmaceutical or cosmetic), state the standard at enquiry and the grade is set against it.

PubChem Public Data

Independent reference data for Avapritinib (CAS 1703793-34-3), compiled from public chemistry databases.

Registry identifiers across databases

CAS Registry Number1703793-34-3
PubChem CID118023034
Molecular formulaC26H27FN10
IUPAC name(1S)-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine
UNII (FDA)513P80B4YJ

Computed descriptors

Molecular Weight498.6
XLogP31.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass498.24041907
Monoisotopic Mass498.24041907
Topological Polar Surface Area106
Heavy Atom Count37

Documented uses on record

    Avapritinib is a tyrosine kinase receptor inhibitor that targets mutant forms of several genes (KIT, PDGFRA) involved in gastrointestinal stromal tumors which are often found in refractory cases. Serum aminotransferase elevations arise in a small proportion of patients treated with the highest doses of avapritinib, but episodes of clinically apparent liver injury have not been reported with its use.Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; Tyrosine Kinase Inhibitors

    Synonyms and trade names

    Avapritinib; 1703793-34-3; BLU-285; Ayvakit; 513P80B4YJ; C-366; 70C366; DTXSID301027935; X720776; X-720776; avapritinibum; RefChem:56916; DTXCID501513502; CS3007; PDGFR alpha/KIT Mutant-specific Inhibitor BLU-285; MFCD31544325

    What the public record says

    Avapritinib · CAS 1703793-34-3 · C26H27FN10. UNII 513P80B4YJ.

    Source: PubChem / Wikidata; the batch COA governs where values differ.

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Supplier: Jinan Shenghe Chemical Co., Ltd.

中文页面: 阿瓦普替尼

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