acivicin

Description

acivicin · CAS 42228-92-2 · C5H7ClN2O3. UNII O0X60K76I6. Solubility: Water 17.9 - 18.2 (mg/mL); Solubility: 0.1 N HCl 31 - 35 (mg/mL); Solubility: 0.1 N NaOH 34.4 - 36.8 (mg/mL).

Identification

Computed Descriptors

Physical & Chemical Properties

Physical description & handling notes

• 0.1 M Citrate buffer pH 4.3 17.1 - 25.7 (mg/mL)
• 0.1 M Borate buffer pH 9.0 8.7 - 13.0 (mg/mL)
• Bulk: A sample stored at 60 °C for 14 days showed no decomposition as indicated by UV absorption, paper chromatography, or ionic chloride determination. Solution: An aqueous solution (18 mg/mL) which was stored at 28°C for 14 days showed less than 1% decomposition by UV absorption, paper chromatography and ionic chloride measurement.

Documented Uses

• Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.
• Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
• Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (From AMA Drug Evaluations Annual, 1994, p2033)
• Antimetabolites that are useful in cancer chemotherapy.
• Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

Synonyms

acivicin; 42228-92-2; Antibiotic AT 125; Acivicine; AT-125; Acivicino; Acivicinum; NSC-163501; AT 125; NSC 163501; (2S)-2-Amino-2-[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]acetic acid; U 42126; U-42126; NSC163501; U-42,126; Acivicina

Frequently Asked Questions

What are the CAS number and molecular formula of acivicin?

CAS 42228-92-2; molecular formula C5H7ClN2O3; molecular weight — g/mol.

What other names is acivicin known by?

acivicin, 42228-92-2, Antibiotic AT 125, Acivicine, AT-125, Acivicino.

What are the key physical properties of acivicin?

Solubility: Water 17.9 - 18.2 (mg/mL); Solubility: 0.1 N HCl 31 - 35 (mg/mL); Solubility: 0.1 N NaOH 34.4 - 36.8 (mg/mL); Solubility: 95% Ethanol 0.8 (mg/mL).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.