乙酰己脲

Description

acetohexamide · CAS 968-81-0 · C15H20N2O4S. UNII QGC8W08I6I. Melting Point: 370 to 374 °F (NTP, 1992); Melting Point: 188-190 °C; Melting Point: 188 - 190 °C.

Identification

CAS Registry Number	968-81-0
PubChem CID	1989
Molecular formula	C15H20N2O4S
IUPAC name	1-(4-acetylphenyl)sulfonyl-3-cyclohexylurea
UNII (FDA)	QGC8W08I6I

Computed Descriptors

Molecular Weight	324.4
XLogP3	2.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Exact Mass	324.11437830
Monoisotopic Mass	324.11437830
Topological Polar Surface Area	101
Heavy Atom Count	22
Formal Charge	0

Physical & Chemical Properties

Melting Point	370 to 374 °F (NTP, 1992)
Melting Point	188-190 °C
Melting Point	188 - 190 °C
Solubility	3430
Solubility	In water, 0.00343 mg/l @ 37 °C
Solubility	4.83e-02 g/L
LogP	2.44
LogP	log Kow= 2.44
LogP	2.7
LogP	1.87

Physical description & handling notes

• Acetohexamide is a white fluffy crystalline powder with almost no odor. (NTP, 1992)
• Solid
• Crystals from 90% aq ethanol
• WHITE CRYSTALLINE POWDER
• PRACTICALLY ODORLESS
• less than 1 mg/mL at 64 °F (NTP, 1992)

Documented Uses

• An orally effective hypoglycemic compound.
• British patent 912,789 (1962 to Lilly); Marshall et al, J Med Chem 6, (1963).
• Benzenesulfonamide, 4-acetyl-N-[(cyclohexylamino)carbonyl]-: INACTIVE
• Used in the management of diabetes mellitus type 2 (adult-onset).
• Breast Feeding; Lactation; Milk, Human; Hypoglycemic Agents; Sulfonylurea Compounds
• ...USED IN TREATMENT OF MILD TO MODERATELY SEVERE DIABETES MELLITUS OF MATURITY-ONSET, NONKETOTIC TYPE IN PT IN WHOM DIET ALONE CANNOT CONTROL GLYCOSURIA.

Synonyms

acetohexamide; 968-81-0; Dymelor; Acetohexamid; Dimelor; Metaglucina; Tsiklamid; Minoral; Ordimel; Hypoglicil; Acetohexamida; Acetohexamidum; 4-Acetyl-N-[(cyclohexylamino)carbonyl]benzenesulfonamide; N-(p-Acetylphenylsulfonyl)-N'-cyclohexylurea; 1-((p-Acetylphenyl)sulfonyl)-3-cyclohexylurea; DTXSID7020007

Frequently Asked Questions

What are the CAS number and molecular formula of acetohexamide?

CAS 968-81-0; molecular formula C15H20N2O4S; molecular weight — g/mol.

What other names is acetohexamide known by?

acetohexamide, 968-81-0, Dymelor, Acetohexamid, Dimelor, Metaglucina.

What are the key physical properties of acetohexamide?

Melting Point: 370 to 374 °F (NTP, 1992); Melting Point: 188-190 °C; Melting Point: 188 - 190 °C; Solubility: 3430.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.