阿必鲁肽

Description

Albiglutide · CAS 782500-75-8 · C148H223N39O46. UNII 5E7U48495E.

Identification

CAS Registry Number	782500-75-8
PubChem CID	122173812
Molecular formula	C148H223N39O46
UNII (FDA)	5E7U48495E

Computed Descriptors

Molecular Weight	3284.6
XLogP3	-14
Hydrogen Bond Donor Count	49
Hydrogen Bond Acceptor Count	51
Rotatable Bond Count	109
Exact Mass	3283.6342956
Monoisotopic Mass	3282.6309408
Topological Polar Surface Area	1380
Heavy Atom Count	233
Formal Charge	0

Physical description & handling notes

• White to yellow powder
• Chemical stability: Material is stable under normal conditions.
• Hazardous decomposition products: Irritating and/or toxic fumes and gases may be emitted upon the products decomposition.
• Solvent is clear, colorless; reconstituted solution is yellow
• Table: Albiglutide Preparations [Table#8276]
• Eperzan

Documented Uses

• Tanzeum is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. /Included in US product label/
• Albiglutide is produced in Saccharomyces cerevisiae using recombinant deoxyribonucleic acid (DNA) technology. The albiglutide drug substance manufacturing process consists of a series of steps which include cell culture, harvest, and purification stages.
• Preparation: C. A. Rosen, W. A. Haseltine, World Intellectual Property Organization patent 03059934; C. A. Rosen et al., USA patent 7141547 (2003, 2006 both to Human Genome Sciences).
• Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
• Albiglutide is a recombinant DNA produced polypeptide analogue of human glucagon-like peptide-1 (GLP-1) which is used in combination with diet and exercise in the therapy of type 2 diabetes, either alone or in combination with other antidiabetic agents. There have been no published reports of hepatotoxicity attributed to albiglutide therapy.
• /BOX WARNING/ Carcinogenicity of albiglutide could not be assessed in rodents, but other glucagon-like peptide-1 (GLP-1) receptor agonists have caused thyroid C-cell tumors in rodents at clinically relevant exposures. Human relevance of GLP-1 receptor agonist induced C-cell tumors in rodents has not been determined. It is unknown whether Tanzeum causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans.

Synonyms

albiglutidum; Albiglutida; RefChem:141; A10BJ04; Albiglutide (genetical recombination); 5E7U48495E; 782500-75-8; Albiglutide; Eperzan; GSK-716155; GSK716155; Tanzeum; CHEBI:78425; SCHEMBL29349999; CHEBI:136045; HGB50075

Frequently Asked Questions

What are the CAS number and molecular formula of Albiglutide?

CAS 782500-75-8; molecular formula C148H223N39O46; molecular weight — g/mol.

What other names is Albiglutide known by?

albiglutidum, Albiglutida, RefChem:141, A10BJ04, Albiglutide (genetical recombination), 5E7U48495E.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.