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Alvespimycin

CAS 467214-20-6C32H48N4O8MW 616.7

Alvespimycin (CAS No. 467214-20-6) is supplied by Jinan Shenghe Chemical Co., Ltd. with a typical purity of 按批次COA提供(不公开发布). Main applications include Pharmaceutical Intermediates & APIs. Bulk quantities are available with COA; purity and packaging are subject to batch COA and order confirmation.

Product Overview

CAS Number467214-20-6
Molecular FormulaC32H48N4O8
Molecular Weight616.7
LogP2
Purity按批次COA提供(不公开发布)
Packaging按订单/批次确认(不公开发布)
ApplicationsPharmaceutical Intermediates & APIs
CategoryPharmaceutical Intermediates & APIs

Applications

Pharmaceutical Intermediates & APIs

Packaging & Storage

Packaging按订单/批次确认(不公开发布)
Purity按批次COA提供(不公开发布)
StorageSealed, cool and dry place
ShippingStandard chemical transport
SampleAvailable on request
Lead TimeIn stock / per order

Quality & Documentation

COA (Certificate of Analysis) is provided with every batch. MSDS/technical data sheets and third-party test reports are available on request. Purity and packaging are subject to batch COA and order confirmation.

Frequently Asked Questions

What is the CAS number of Alvespimycin?

The CAS number of Alvespimycin is 467214-20-6.

What purity and packaging are available?

Typical purity is 按批次COA提供(不公开发布), supplied in 按订单/批次确认(不公开发布), with COA provided.

What are the applications of Alvespimycin?

Main applications include Pharmaceutical Intermediates & APIs.

How do I buy Alvespimycin or get a quote?

Email info@591daili.com or reach us on WhatsApp with the product name, CAS number and required quantity; quotes within one business day. Supplier: Jinan Shenghe Chemical Co., Ltd..

PubChem Public Data

Description

Alvespimycin · CAS 467214-20-6 · C32H48N4O8. UNII 001L2FE0M3.

Identification

CAS Registry Number467214-20-6
PubChem CID5288674
Molecular formulaC32H48N4O8
IUPAC name[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-[2-(dimethylamino)ethylamino]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate
UNII (FDA)001L2FE0M3

Computed Descriptors

Molecular Weight616.7
XLogP32
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count10
Rotatable Bond Count8
Exact Mass616.34721450
Monoisotopic Mass616.34721450
Topological Polar Surface Area170
Heavy Atom Count44
Formal Charge0

Physical description & handling notes

  • Soluble

GHS Hazard Classification

Reported hazard statementsH302 (100%), H312 (100%), H319 (100%)

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]

Documented Uses

  • Investigated for use as an antineoplastic agent for solid tumors, advanced solid tumours or acute myeloid leukaemia.
  • Increasing concentration of the drug results in dose-proportional increase in the plasma concentration. At the maximum tolerated dose of 80mg/m^2, the plasma concentration exceeded 63nM (mean IC50 for 17-DMAG in the NCI 60 human tumor cell line panel) for less than 24 hours in all patients. The mean peak concentration (Cmax) reached 2680 nmol/L at this dose.
  • Mainly renal and biliary elimination pathways. In a mice study, the excreted urine 24 hours post-dose recovered 10.6–14.8% of delivered dose unchanged.
  • At the maximum tolerated dose of 80mg/m^2, the mean Vd value is 385 L.
  • The mean clearance is 18.9 L/hr at the dose of 80mg/m^2.
  • Alvespimycin demonstrates redox cycling catalyzed by purified human cytochrome P450 reductase (CYP3A4/3A5) to quinones and hydroquinones. It could also form glutathione conjugates at the 19-position on the quinone ring. However in vivo and in vitro studies suggest that weak metabolism of alvespimysin occurs in humans.

Synonyms

alvespimycin; 467214-20-6; 17-DMAG; Alvespimycin [INN]; alvespimicina; alvespimycine; UNII-001L2FE0M3; 17-dimethylaminoethylamino-17-demethoxygeldanamycin; CHEBI:65324; 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin; NSC707545; NSC-707545; ALVESPIMYCIN [WHO-DD]; 17-DESMETHOXY-17-N,N-DIMETHYLAMINOETHYLAMINO-GELDANAMYCIN; 17-dimethylaminoethylamino-17-demethoxy-geldanamycin; 17-(dimethylaminoethylamino)-17-demethoxy-geldanamycin

Frequently Asked Questions

What are the CAS number and molecular formula of Alvespimycin?

CAS 467214-20-6; molecular formula C32H48N4O8; molecular weight — g/mol.

What other names is Alvespimycin known by?

alvespimycin, 467214-20-6, 17-DMAG, Alvespimycin [INN], alvespimicina, alvespimycine.

Is Alvespimycin classified as hazardous?

Hazard statements reported: H302, H312, H319.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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