阿尔维螺旋霉素

Name: 阿尔维螺旋霉素
Brand: 济南圣和化工有限公司

CAS 467214-20-6C32H48N4O8MW 616.7

阿尔维螺旋霉素（CAS 467214-20-6）属医药中间体及原料药类产品，分子式 C32H48N4O8，分子量 616.7。济南圣和化工有限公司常年现货供应该产品，常规纯度按批次COA提供(不公开发布)，可按客户需求安排分装包装，欢迎邮件或来电询价。

产品概览

CAS号	467214-20-6
分子式	C32H48N4O8
分子量	616.7
LogP	2
纯度	按批次COA提供(不公开发布)
包装	按订单/批次确认(不公开发布)
应用领域	医药中间体及原料药
类别	医药中间体及原料药

应用领域

医药中间体及原料药

阿尔维螺旋霉素在医药中间体及原料药领域使用广泛。采购前请确认纯度等级与包装形式，以批次 COA 为验收依据。

包装与储存

包装规格按订单/批次确认(不公开发布)

纯度规格按批次COA提供(不公开发布)

储存条件密封、阴凉干燥处保存

运输常规化工运输

样品可协商提供

交期现货/按订单安排

供应说明：阿尔维螺旋霉素常规包装为按订单/批次确认(不公开发布)，储存时应密封置于阴凉干燥处，避免与氧化剂混放。济南圣和化工有限公司支持国内物流发货，大货交期与运费以订单确认为准。

质量与文件

每批产品随货提供 COA（分析证书）；可按需提供 MSDS/技术数据表及第三方检测报告。纯度与包装以批次 COA 及订单确认为准。

关于供应商

选择济南圣和化工有限公司的理由：产品信息透明（含 CAS、分子式、理化参数）、报价响应快（一个工作日内）、单证齐全（COA/MSS/质检资料按需提供）、支持批量与长期协议供货。如需阿尔维螺旋霉素以外的配套原料，也欢迎一并列出需求清单。

常见问题

阿尔维螺旋霉素的 CAS 号是多少？

阿尔维螺旋霉素的 CAS 号为 467214-20-6。

该产品的纯度和包装规格是什么？

常规纯度规格为按批次COA提供(不公开发布)，包装为按订单/批次确认(不公开发布)，随货提供 COA。

阿尔维螺旋霉素有什么用途？

主要应用于医药中间体及原料药。

如何购买或获取报价？

请发送邮件至 info@591daili.com 或通过 WhatsApp 联系，注明产品名称、CAS 号与需求数量，一个工作日内回复报价。供应商：济南圣和化工有限公司。

PubChem 公开数据

Description

Alvespimycin · CAS 467214-20-6 · C32H48N4O8. UNII 001L2FE0M3.

Identification

CAS Registry Number	467214-20-6
PubChem CID	5288674
Molecular formula	C32H48N4O8
IUPAC name	[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-[2-(dimethylamino)ethylamino]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate
UNII (FDA)	001L2FE0M3

Computed Descriptors

Molecular Weight	616.7
XLogP3	2
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	8
Exact Mass	616.34721450
Monoisotopic Mass	616.34721450
Topological Polar Surface Area	170
Heavy Atom Count	44
Formal Charge	0

Physical description & handling notes

Soluble

GHS Hazard Classification

Reported hazard statements	H302 (100%), H312 (100%), H319 (100%)

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]

Documented Uses

Investigated for use as an antineoplastic agent for solid tumors, advanced solid tumours or acute myeloid leukaemia.
Increasing concentration of the drug results in dose-proportional increase in the plasma concentration. At the maximum tolerated dose of 80mg/m^2, the plasma concentration exceeded 63nM (mean IC50 for 17-DMAG in the NCI 60 human tumor cell line panel) for less than 24 hours in all patients. The mean peak concentration (Cmax) reached 2680 nmol/L at this dose.
Mainly renal and biliary elimination pathways. In a mice study, the excreted urine 24 hours post-dose recovered 10.6–14.8% of delivered dose unchanged.
At the maximum tolerated dose of 80mg/m^2, the mean Vd value is 385 L.
The mean clearance is 18.9 L/hr at the dose of 80mg/m^2.
Alvespimycin demonstrates redox cycling catalyzed by purified human cytochrome P450 reductase (CYP3A4/3A5) to quinones and hydroquinones. It could also form glutathione conjugates at the 19-position on the quinone ring. However in vivo and in vitro studies suggest that weak metabolism of alvespimysin occurs in humans.

Synonyms

alvespimycin; 467214-20-6; 17-DMAG; Alvespimycin [INN]; alvespimicina; alvespimycine; UNII-001L2FE0M3; 17-dimethylaminoethylamino-17-demethoxygeldanamycin; CHEBI:65324; 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin; NSC707545; NSC-707545; ALVESPIMYCIN [WHO-DD]; 17-DESMETHOXY-17-N,N-DIMETHYLAMINOETHYLAMINO-GELDANAMYCIN; 17-dimethylaminoethylamino-17-demethoxy-geldanamycin; 17-(dimethylaminoethylamino)-17-demethoxy-geldanamycin

Frequently Asked Questions

What are the CAS number and molecular formula of Alvespimycin?

CAS 467214-20-6; molecular formula C32H48N4O8; molecular weight — g/mol.

What other names is Alvespimycin known by?

alvespimycin, 467214-20-6, 17-DMAG, Alvespimycin [INN], alvespimicina, alvespimycine.

Is Alvespimycin classified as hazardous?

Hazard statements reported: H302, H312, H319.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.