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Alvespimycin

CAS 467214-20-6C32H48N4O8MW 616.7

Alvespimycin (CAS 467214-20-6) — formula C32H48N4O8, molecular weight 616.7; category pharmaceutical intermediates and APIs.

Product Description

Alvespimycin (CAS 467214-20-6) is a chemical raw material in the pharmaceutical intermediates and APIs category. Its molecular formula C32H48N4O8 comprises 32 C, 48 H, 4 N, 8 O atoms. Its molecular weight is about 616.7. Reported physicochemical data: LogP about 2. As a sourcing and distribution partner we help locate and compare this item across domestic and cross-border channels, arranging samples and batch orders with full COA and compliance files.

Product Overview

CAS Number467214-20-6
Molecular FormulaC32H48N4O8
Molecular Weight616.7
LogP2
CategoryPharmaceutical Intermediates & APIs

Technical Profile

What this product is

Alvespimycin is a pharmaceutical intermediate or API compound with CAS registry number 467214-20-6 and molecular formula C32H48N4O8 (molecular weight 616.7), belonging to the pharmaceutical intermediates and APIs segment of chemical raw materials.

Identification

CAS number: 467214-20-6

Its molecular formula C32H48N4O8 comprises 32 C, 48 H, 4 N, 8 O atoms.

Also known as: Alvespimycin · 阿尔维螺旋霉素

Category: pharmaceutical intermediates and APIs

Frequently Asked Questions

What is the CAS number of Alvespimycin?

The CAS registry number of Alvespimycin is 467214-20-6.

What is the molecular formula and molecular weight of Alvespimycin?

Molecular formula C32H48N4O8, molecular weight 616.7.

What other names is Alvespimycin known by?

It is also registered under: Alvespimycin, 阿尔维螺旋霉素.

Which category does Alvespimycin belong to?

Category: Pharmaceutical Intermediates & APIs.

Packaging & documentation

Packaging is agreed per order, from lab-scale packs to bulk, and confirmed with each order rather than fixed on the page. A Certificate of Analysis (COA) ships with every batch and MSDS is available; where the end use carries a regulatory limit (food contact, pharmaceutical or cosmetic), state the standard at enquiry and the grade is set against it.

PubChem Public Data

Independent reference data for Alvespimycin (CAS 467214-20-6), compiled from public chemistry databases.

Registry identifiers across databases

CAS Registry Number467214-20-6
PubChem CID5288674
Molecular formulaC32H48N4O8
IUPAC name[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-[2-(dimethylamino)ethylamino]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate
UNII (FDA)001L2FE0M3

Computed descriptors

Molecular Weight616.7
XLogP32
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count10
Rotatable Bond Count8
Exact Mass616.34721450
Monoisotopic Mass616.34721450
Topological Polar Surface Area170
Heavy Atom Count44

Documented uses on record

    Investigated for use as an antineoplastic agent for solid tumors, advanced solid tumours or acute myeloid leukaemia.Increasing concentration of the drug results in dose-proportional increase in the plasma concentration. At the maximum tolerated dose of 80mg/m^2, the plasma concentration exceeded 63nM (mean IC50 for 17-DMAG in the NCI 60 human tumor cell line panel) for less than 24 hours in all patients. The mean peak concentration (Cmax) reached 2680 nmol/L at this dose.

    Synonyms and trade names

    alvespimycin; 467214-20-6; 17-DMAG; Alvespimycin [INN]; alvespimicina; alvespimycine; UNII-001L2FE0M3; 17-dimethylaminoethylamino-17-demethoxygeldanamycin; CHEBI:65324; 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin; NSC707545; NSC-707545; ALVESPIMYCIN [WHO-DD]; 17-DESMETHOXY-17-N,N-DIMETHYLAMINOETHYLAMINO-GELDANAMYCIN; 17-dimethylaminoethylamino-17-demethoxy-geldanamycin; 17-(dimethylaminoethylamino)-17-demethoxy-geldanamycin

    GHS hazard classification

    Reported hazard statementsH302 (100%), H312 (100%), H319 (100%)

    H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

    H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]

    What the public record says

    Alvespimycin · CAS 467214-20-6 · C32H48N4O8. UNII 001L2FE0M3.

    Source: PubChem / Wikidata; the batch COA governs where values differ.

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Supplier: Jinan Shenghe Chemical Co., Ltd.

中文页面: 阿尔维螺旋霉素

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