柠檬酸阿尔维林

Description

alverine citrate · CAS 5560-59-8 · C20H27N. UNII 46TIR1560O. Boiling Point: 212.5; Boiling Point: 165-168 °C @ 0.3 MM HG; Melting Point: < 25 °C.

Identification

CAS Registry Number	5560-59-8
PubChem CID	3678
Molecular formula	C20H27N
IUPAC name	N-ethyl-3-phenyl-N-(3-phenylpropyl)propan-1-amine
UNII (FDA)	46TIR1560O

Computed Descriptors

Molecular Weight	281.4
XLogP3	5.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	9
Exact Mass	281.214349865
Monoisotopic Mass	281.214349865
Topological Polar Surface Area	3.2
Heavy Atom Count	21
Formal Charge	0

Physical & Chemical Properties

Boiling Point	212.5
Boiling Point	165-168 °C @ 0.3 MM HG
Melting Point	< 25 °C
Solubility	9.60e-04 g/L

Physical description & handling notes

• Solid
• LIQUID
• SIRUP; SOL IN WATER /HYDROCHLORIDE/
• FREELY SOL IN WATER; CRYSTALS /CITRATE/
• SLIGHTLY SOL IN CHLOROFORM; SOL IN DIL ACIDS; SPARINGLY SOL IN ALC; VERY SLIGHTLY SOL IN ETHER; SWEET ODOR & SLIGHTLY BITTER TASTE /CITRATE/
• 160.14 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Regulatory Status

GHS notification summary	66.7% (2 / 3)

GHS Hazard Classification

GHS notification summary	66.7% (2 / 3)
Reported hazard statements	H302 (33.3%), H312 (33.3%), H332 (33.3%)

Documented Uses

• PREPD FROM PHENYLPROPYL CHLORIDE & ETHYLAMINE IN ALKALINE MEDIUM: KULZ ET AL, BER 72, 2165 (1939); ALTERNATE ROUTE: STUHNER, ELBRACHTER, ARCH PHARM 287, 139 (1954).
• Used to relieve cramps or spasms of the stomach and intestines. It is also useful in treating irritable bowel syndrome (IBS) and similar conditions. It can also be used to help relieve period pain. Alverine citrate is also under investigation to increase the cytotoxic effects of the proteasome inhibitor MG132 on breast cancer cells.
• IT IS USED IN MGMNT OF GI DISORDERS IN WHICH HYPERMOTILITY OR SPASM IS INVOLVED...& IN GENITOURINARY SPASM SUCH AS MAY ACCOMPANY PASSAGE OF STONE, URINARY TRACT INFECTION, OR PROSTATIC HYPERTROPHY. ... IT MAY ALSO BE USED IN CERTAIN PRIMARY DYSMENORRHEAS & TO AID IN VARIOUS ENDOSCOPIC EXAM. /CITRATE/
• STERCULIA GUM WITH & WITHOUT SMOOTH MUSCLE RELAXANT ALVERINE HAD SIMILAR BENEFICIAL EFFECTS ON CONSTIPATION & REDUCED TRANSIT TIMES IN DIVERTICULAR DISEASE IN 2 GROUPS OF 10 PT STUDIED.
• IT PROBABLY SHOULD BE USED WITH CAUSTION IN AGED & ARTERIOSCLEROTIC PT & IN PRESENCE OF ANGINA PECTORIS. /CITRATE/
• Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS.

Synonyms

ALVERINE; 150-59-4; Phenopropamine; Phenpropamine; Profenil; Dipropylin; Dipropyline; Sestron; Di(phenylpropyl)ethylamine; N-Ethyl-3,3'-diphenyldipropylamine; Alverina; Sestron base; Bis(gamma-phenylpropyl)ethylamine; ethylbis(3-phenylpropyl)amine; Alverinum; N,N-Bis(3-phenylpropyl)ethylamine

Frequently Asked Questions

What are the CAS number and molecular formula of alverine citrate?

CAS 5560-59-8; molecular formula C20H27N; molecular weight — g/mol.

What other names is alverine citrate known by?

ALVERINE, 150-59-4, Phenopropamine, Phenpropamine, Profenil, Dipropylin.

Is alverine citrate classified as hazardous?

66.7% of GHS notifications report no hazard classification (2 of 3).

What are the key physical properties of alverine citrate?

Boiling Point: 212.5; Boiling Point: 165-168 °C @ 0.3 MM HG; Melting Point: < 25 °C; Solubility: 9.60e-04 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.