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Axitinib

CAS 319460-85-0C22H18N4OSMW 386.5

Axitinib (CAS 319460-85-0) — formula C22H18N4OS, molecular weight 386.5.

Product Overview

CAS Number319460-85-0
Molecular FormulaC22H18N4OS
Molecular Weight386.5
LogP3.8

Technical Profile

What this product is

Axitinib is a chemical compound with CAS registry number 319460-85-0 and molecular formula C22H18N4OS (molecular weight 386.5).

Identification

CAS number: 319460-85-0

Its molecular formula C22H18N4OS comprises 22 C, 18 H, 4 N, 1 O, 1 S atoms.

Also known as: Axitinib · 阿西替尼

Frequently Asked Questions

What is the CAS number of Axitinib?

The CAS registry number of Axitinib is 319460-85-0.

What is the molecular formula and molecular weight of Axitinib?

Molecular formula C22H18N4OS, molecular weight 386.5.

What other names is Axitinib known by?

It is also registered under: Axitinib, 阿西替尼.

PubChem Public Data

Independent reference data for Axitinib (CAS 319460-85-0), compiled from public chemistry databases.

Registry identifiers across databases

CAS Registry Number319460-85-0
PubChem CID6450551
Molecular formulaC22H18N4OS
IUPAC nameN-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide
UNII (FDA)C9LVQ0YUXG

Computed descriptors

Molecular Weight386.5
XLogP34.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass386.12013238
Monoisotopic Mass386.12013238
Topological Polar Surface Area96
Heavy Atom Count28

Physicochemical values on record

LogP3.8
Dissociation Constants4.8

Documented uses on record

    Used in kidney cell cancer and investigated for use/treatment in pancreatic and thyroid cancer.Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; Tyrosine Kinase Inhibitors

    Synonyms and trade names

    Axitinib; 319460-85-0; Inlyta; AG-13736; axitinibum; C9LVQ0YUXG; DTXSID3049049; AG013736; NSC-757441; N-methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide; N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide; DTXCID8028975; CHEBI:66910; Benzamide, N-methyl-2-((3-((E)-2-(2-pyridinyl)ethenyl)-1H-indazol-6-yl)thio)-; N-methyl-2-({3-[(1E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide; Benzamide, N-methyl-2-((3-((1E)-2-(2-pyridinyl)ethenyl)-1H-indazo)-6-yl)thio)-

    GHS hazard classification

    Reported hazard statementsH302 (53.4%), H341 (43.8%), H361 (43.8%), H373 (43.8%), H400 (56.2%)

    H302 (53.4%): Harmful if swallowed [Warning Acute toxicity, oral]

    H341 (43.8%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]

    What the public record says

    Axitinib · CAS 319460-85-0 · C22H18N4OS. UNII C9LVQ0YUXG. LogP: 3.8; Dissociation Constants: 4.8.

    Physical description and handling notes

    Source: PubChem / Wikidata; the batch COA governs where values differ.

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