盐酸阿洛司琼

Description

Alosetron hydrochloride · CAS 122852-69-1 · C17H19ClN4O. UNII 2F5R1A46YW. Melting Point: 288-291 °C.

Identification

CAS Registry Number	122852-69-1
PubChem CID	60758
Molecular formula	C17H19ClN4O
IUPAC name	5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4-dihydropyrido[4,3-b]indol-1-one;hydrochloride
UNII (FDA)	2F5R1A46YW

Computed Descriptors

Molecular Weight	330.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	330.1247389
Monoisotopic Mass	330.1247389
Topological Polar Surface Area	53.9
Heavy Atom Count	23
Formal Charge	0
Complexity	442

Physical & Chemical Properties

Melting Point	288-291 °C

Physical description & handling notes

• White to beige solid with a solubility of 61 mg/ml in water, 42 mg/ml in 0.1M hydrochloric acid, 0.3 mg/ml in pH 6 phosphate buffer, and <0.1 mg/ml in pH 8 phosphate buffer /Hydrochloride/
• Mol wt: 294.35. /Alosetron/
• The main ingredient in the drug Lotronex ... (tablets)

GHS Hazard Classification

Reported hazard statements	H301 (100%), H319 (97.7%), H412 (93%)

Documented Uses

• Preparation: I.H. Coates et al., EP 306323; eidem, US 5360800 (1989, 1994 both to Glaxo)
• Alosetron, a selective 5-HT3-receptor antagonist, is indicated for the treatment of irritable bowel syndrome in female patients whose predominant symptom is diarrhea. /Salt not specified/
• ... Animal models have shown it to be active in anxiety, psychosis, cognitive impairment, emesis & drug withdrawal, though its application in humans has been almost entirely restricted to irritable bowel syndrome (IBS). ... Alosetron appears promising in the treatment of abdominal pain & discomfort & normalising of bowel function in patients with non-constipated IBS. It also improves quality of life, has a high degree of tolerability & has an excellent safety profile to date. /Salt not specified/
• Plasma concentrations of alosetron are 30 to 50% lower in men than in women given the same oral dose. In patients with irritable bowel syndrome, concentrations of alosetron are influenced by gender. Efficacy has not been established in men at any dose. /Salt not specified/
• /Alosetron/ should not be used in irritable bowel syndrome patients currently constipated or whose predominant bowel symptom in constipation because constipation is a frequent side effect of alosetron. /Salt not specified/
• ... Constipation is the most frequent adverse event, with a higher incidence of transient constipation in alosetron-treated patients, typically occurring in the first month of treatment. /Salt not specified/

Synonyms

ALOSETRON HYDROCHLORIDE; 122852-69-1; Alosetron HCl; GR 68755c; Lotrpnex; DTXSID8044208; GR-68755C; 2F5R1A46YW; DTXCID6024208; 2,3,4,5-Tetrahydro-5-methyl-2-((5-methylimidazol-4-yl)methyl)-1H-pyrido(4,3-b)indol-1-one monohydrochloride; CHEBI:53783; RefChem:58091; 132414-02-9; Alosetron hydrochloride [USAN]; Alosetron (Hydrochloride); Alosetron Hydrochloride(1:X)

Frequently Asked Questions

What are the CAS number and molecular formula of Alosetron hydrochloride?

CAS 122852-69-1; molecular formula C17H19ClN4O; molecular weight — g/mol.

What other names is Alosetron hydrochloride known by?

ALOSETRON HYDROCHLORIDE, 122852-69-1, Alosetron HCl, GR 68755c, Lotrpnex, DTXSID8044208.

Is Alosetron hydrochloride classified as hazardous?

Hazard statements reported: H301, H319, H412.

What are the key physical properties of Alosetron hydrochloride?

Melting Point: 288-291 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.