西甲硅油

Description

POLYDIMETHYLSILOXANE · CAS 8050-81-5 · C6H18O4Si3. UNII SIMETICONE.

Identification

CAS Registry Number	8050-81-5
PubChem CID	6433516
Molecular formula	C6H18O4Si3
IUPAC name	dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane
UNII (FDA)	SIMETICONE

Computed Descriptors

Molecular Weight	238.46
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	238.05128865
Monoisotopic Mass	238.05128865
Topological Polar Surface Area	52.6
Heavy Atom Count	13
Formal Charge	0
Complexity	125

Physical description & handling notes

• Gray, translucent, viscous liquid
• Liquid
• Insoluble in water
• Insoluble in alcohol
• 0.98 /Polydimethyl Silicones/
• Stable under recommended storage conditions.

Regulatory Status

Regulatory & Food Contact	ANTICAKING_AGENT; ANTIFOAMING_AGENT: Food Additives DIMETHYLPOLYSILOXANE 0–1.5 mg/kg bw The Committee withdrew the temporary ADI of 0–0.8 mg/kg body weight per day and re-established the ADI of 0â TRS 966-JECFA 74/27 FAS 60-JECFA 69/165
GHS notification summary	96.6% (86 / 89)

GHS Hazard Classification

GHS notification summary	96.6% (86 / 89)
Reported hazard statements	H225 (100%), H319 (100%), H335 (100%), H336 (100%)

Documented Uses

• The main use of simethicone as an excipient is as an antifoaming agent in pharmaceutical manufacturing processes ... .
• A poly(dimethylsiloxane) which is a polymer of 200-350 units of dimethylsiloxane, along with added silica gel. It is used as an antiflatulent, surfactant, and ointment base.
• Antifoaming ingredient in cosmetics
• Simethicone manufactured under the name of MED-340 is used in the production of anti-gas tablets; lubrication and bubble free application of topical preparations; anti-whitening properties in acne and other dermatological ointments, creams and lotions; as an antifoam in the manufacture of drug products made by microbial fermentations; listed in the INCI index for use in cosmetic and toiletry products.
• For more Uses (Complete) data for Simethicone (6 total), please visit the HSDB record page.
• Food Additives -> ANTICAKING_AGENT; ANTIFOAMING_AGENT -> JECFA Functional Classes

Synonyms

Simethicone; 8050-81-5; Sentry Simethicone; Mylanta Gas Relief; Mylicon Infant's Drops; Sentry Simethicone Emulsion; DTXSID00904918; RefChem:886342; 3,3,5,5-tetramethyl-2,4-dioxa-3,5-disilahexane; silanedione; 617-098-1; dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane; Simethicon; Simethicone(200); Simethicone(500); SIMETICONE; C6H18O4Si3

Frequently Asked Questions

What are the CAS number and molecular formula of POLYDIMETHYLSILOXANE?

CAS 8050-81-5; molecular formula C6H18O4Si3; molecular weight — g/mol.

What other names is POLYDIMETHYLSILOXANE known by?

Simethicone, 8050-81-5, Sentry Simethicone, Mylanta Gas Relief, Mylicon Infant's Drops, Sentry Simethicone Emulsion.

What is the regulatory status of POLYDIMETHYLSILOXANE?

Documented regulatory listings: ANTICAKING_AGENT; ANTIFOAMING_AGENT: Food Additives; DIMETHYLPOLYSILOXANE; 0–1.5 mg/kg bw.

Is POLYDIMETHYLSILOXANE classified as hazardous?

96.6% of GHS notifications report no hazard classification (86 of 89).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.